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Cited by 123Neuroinflammation and Neurodegeneration MechanismsCerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ

Negi, Neema, Das, Bimal K.·2018·International Reviews of Immunology
DOI 10.1080/08830185.2017.1357719
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Abstract

The cardinal dogma of central nervous system (CNS) immunology believed brain is an immune privileged site, but scientific evidences gathered so far have overturned this notion proving that CNS is no longer an immune privileged site, but rather an actively regulated site of immune surveillance. Landmark discovery of lymphatic system surrounding the duramater of the brain, made possible by high resolution live imaging technology has given new dimension to neuro-immunology. Here, we discuss the immune privilege status of CNS in light of the previous and current findings, taking into account the differences between a healthy state and changes that occur during an inflammatory response. Cerebrospinal fluid (CSF) along with interstitial fluid (ISF) drain activated T cells, natural killer cells, macrophages and dendritic cells from brain to regional lymph nodes present in the head and neck region. To keep an eye on inflammation, this system hosts an army of regulatory T cells (CD25+ FoxP3+) that regulate T cell hyper activation, proliferation and cytokine production. This review is an attempt to fill the gaps in our understanding of neuroimmune interactions, role of innate and adaptive immune system in maintaining homeostasis, interplay of different immune cells, immune tolerance, knowledge of communication pathways between the CNS and the peripheral immune system and lastly how interruption of immune surveillance leads to neurodegenerative diseases. We envisage that discoveries should be made not only to decipher underlying cellular and molecular mechanisms of immune trafficking, but should aid in identifying targeted cell populations for therapeutic intervention in neurodegenerative and autoimmune disorders.

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Crossref · 10.1080/08830185.2017.1357719

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Research works printed but not linked: 13

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Metadata

Authors
Negi, N., & Das, B. K.
Affiliations
  • Umeå University (SE)
  • All India Institute of Medical Sciences (IN)
Corresponding author
Das, Bimal K.
ORCID
Venue
International Reviews of Immunology
Publisher
Informa UK Limited
Published
2017-09-29
Volume
37
Issue
1
Pages
57-68
ISSN
  • 0883-0185 (ISSN-L)
  • 1563-5244
DOI
10.1080/08830185.2017.1357719
OpenAlex
W2760038100
Cited by
123
References
74
Citations by year
2026: 6 · 2025: 8 · 2024: 11 · 2023: 19 · 2022: 14 · 2021: 27 · 2020: 17 · 2019: 7 · 2018: 13 · 2017: 1
FWCI
1.00
Type
journal article
Language
en
Open access
closed
Locations
  • International Reviews of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
immune privilege, cerebrospinal fluid, interstitial fluid, immune surveillance, regulatory T cells, neuroinflammation, neuroimmune interactions, immune tolerance, neurodegenerative diseases, autoimmune disease, dendritic cells, macrophages, natural killer cells
MeSH terms
Alzheimer Disease, Animals, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Humans, Immunologic Surveillance, Lymphatic System, Macrophages, Models, Neurological, Monocytes, Multiple Sclerosis, Parkinson Disease, Neuroimmunomodulation, Microglia, Antigen Presentation, Models, Immunological, Mice

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