Insulin resistance and body composition in Turner syndrome: effect of sequential change in the route of estrogen administration
Abstract
The aim of the present study was to examine the impact of sequential change in the route of estrogen administration on body composition and insulin resistance in patients with Turner syndrome (TS) using cyclical hormone replacement therapy (HRT) with conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA). We carried out a self-controlled study of nine non-obese patients with TS, with an average age of 23 +/- 4.9 years. Body mass index (BMI), waist-to-hip ratio (WHR), fasting glycemia, insulin tolerance (glucose disappearance constant during an insulin tolerance test, kITT) and body composition (dual-energy X-ray absorptiometry) were studied after 1 year's use of CEE plus MPA and repeated after 1 year's use of 17beta-estradiol gel with the same schedule of MPA administration. We did not observe any difference between the oral and percutaneous HRT with regard to BMI, WHR and insulin tolerance (kITT: 4.9 +/- 1.5 vs. 5.3 +/- 1.5%/min, p = 0.8). During administration of the 17beta-estradiol gel a tendency to increased total lean mass (p = 0.054) was observed. We conclude that sequential change in the route of estrogen administration in TS patients using cyclical HRT with CEE and MPA does not affect insulin resistance, although use of percutaneous 17beta-estradiol gel seems to exert favorable changes in body composition.
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Dose and route of E2 do not affect glucose and insulin concentration and tolerance.
“Dose and route of E2 do not affect glucose and insulin concentration and tolerance”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [341]
TD vs oral HRT shows no significant differences in protein turnover, lipolysis, osteocalcin, C-reactive protein, BMI, or waist-to-hip ratio.
“TD vs oral HRT: no significant differences in protein turnover, lipolysis, osteocalcin, C-reactive protein, BMI, or waist-to-hip ratio”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [341]
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- Authors
- de Figueiredo Alves, S. T., Gallichio, C. T., & Guimarães, M. M.
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 22
- Issue
- 10
- Pages
- 590-594
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2079211291
- Cited by
- 24
- References
- 30
- Citations by year
- 2024: 1 · 2022: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- Turner syndrome, insulin resistance, body composition, conjugated equine estrogens, medroxyprogesterone acetate, hormone replacement therapy, insulin tolerance test, lean body mass, waist-to-hip ratio, body mass index
- MeSH terms
- Adolescent, Adult, Blood Glucose, Body Composition, Drug Administration Routes, Estrogens, Conjugated (USP), Female, Humans, Insulin Resistance, Turner Syndrome, Estrogen Replacement Therapy, Body Mass Index, Body Fat Distribution
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