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Cited by 31Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes and associated disorders

New insights on diabetes in Turner syndrome: results from an observational study in adulthood

Ibarra-Gasparini, Daniela, Altieri, Paola, Scarano, Emanuela, Perri, Annamaria, Morselli-Labate, Antonio M., Pagotto, Uberto, Mazzanti, Laura, Pasquali, Renato +1 more·2018·Endocrine
DOI 10.1007/s12020-017-1336-z
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Abstract

Objective To explore the characteristics of diabetes mellitus in adults with Turner syndrome.Design Observational study consisting of a prospective phase after the access of adults with Turner syndrome to the Endocrinology Unit (median period of follow-up 15.6, interquartile range: 12.0-24.5 months) and a retrospective collection of data from the diagnosis of Turner syndrome until the time of access to the Endocrinology Unit. A total of 113 Italian Turner syndrome patients were included in the study. During the prospective phase of the study, each patient underwent physical examination, fasting blood sampling, and an oral glucose tolerance test on a yearly basis. Oral glucose tolerance test was used to perform the diagnosis of diabetes mellitus.Results Before access to the Endocrinology Unit, diabetes mellitus was diagnosed in two Turner syndrome patients. Another five cases of diabetes mellitus were diagnosed at the first access to the Endocrinology Unit, whereas seven new cases of diabetes mellitus were diagnosed during the prospective phase of the study. At the diagnosis of diabetes mellitus, only one patient had fasting glucose above 126 mg/dL, and only two had an HbA1c value >6.5% (48 mmol/mol). When compared to normo-glucose tolerant patients, the diabetic patients had a significantly lower insulin-to-glucose ratio at 30 and 60 min of the oral glucose tolerance test. In the regression analyses, only age was associated with the development of diabetes mellitus.Conclusions This study confirms that diabetes mellitus is frequent in Turner syndrome and suggests that it is specific to the syndrome. In addition, this study demonstrates that oral glucose tolerance test is a more sensitive test than HbA1c for the diagnosis of diabetes mellitus in Turner syndrome.

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  • Diabetes mellitus is common in TS, with studies reporting a 25%-70% lifetime prevalence.

    “Diabetes mellitus is common in TS, with studies reporting a 25%-70% lifetime prevalence.703-705”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [704]

  • Several studies support that diabetes occurs at an earlier age and is less likely to involve the usual risk factors (BMI, body composition, and family history) in TS compared to the general population.

    “Several studies support that diabetes occurs at an earlier age384,708 and is less likely to involve the usual risk factors (BMI, body composition, and family history) in TS compared to the general population.704”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [704]

  • Several studies have demonstrated that fasting glucose and hemoglobin A1c can be normal even in the setting of impaired glucose tolerance in individuals with TS.

    “Several studies have demonstrated that fasting glucose and hemoglobin A1c can be normal even in the setting of impaired glucose tolerance in individuals with TS.704,708”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [704]

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Authors
Ibarra-Gasparini, D., Altieri, P., Scarano, E., Perri, A., Morselli-Labate, A. M., Pagotto, U., Mazzanti, L., Pasquali, R., & Gambineri, A.
Affiliations
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Corresponding author
Gambineri, Alessandra
ORCID
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2017-06-07
Volume
59
Issue
3
Pages
651-660
ISSN
  • 0969-711X (ISSN-L)
  • 1355-008X
  • 1559-0100
DOI
10.1007/s12020-017-1336-z
OpenAlex
W2623394958
Cited by
31
References
31
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2017: 2
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
Turner syndrome, diabetes mellitus, type 2 diabetes, oral glucose tolerance test, HbA1c, insulin/glucose ratio, diabetes diagnosis, age as risk factor, fasting blood glucose
MeSH terms
Adult, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Insulin, Middle Aged, Prospective Studies, Retrospective Studies, Turner Syndrome, Young Adult

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