Glucose metabolism in Turner syndrome
Open accessAbstract
Turner syndrome (TS) is one of the most common female chromosomal disorders. The condition is caused by complete or partial loss of a single X chromosome. Adult patients with TS have a high prevalence of diabetes mellitus (DM). Deranged glucose metabolism in this population seems to be genetically triggered. The traditional risk factors for DM in the general population may not play a major role in the pathogenesis of DM in patients with TS. This review focuses on the latest research studies pertaining to abnormalities of glucose metabolism in TS. We extensively review the available evidence pertaining to the influence of insulin secretion and sensitivity, obesity, autoimmunity, lifestyle, growth hormone, and sex hormone replacement therapy on the occurrence of DM in these patients.
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Diabetes mellitus is common in TS, with studies reporting a 25%-70% lifetime prevalence.
“Diabetes mellitus is common in TS, with studies reporting a 25%-70% lifetime prevalence.703-705”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [705]
Multiple studies demonstrate impaired beta cell function as well as reduced insulin sensitivity are involved in the development of diabetes in TS, while one study found glucose intolerance despite apparently normal beta cell function.
“Furthermore, multiple studies demonstrate impaired beta cell function as well as reduced insulin sensitivity are involved in the development of diabetes in TS ,227,229,384,705,707,708 while one study found glucose intolerance despite apparently normal beta cell function.709”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [705]
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
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- Authors
- Sun, L., Wang, Y., Zhou, T., Zhao, X., Wang, Y., Wang, G., & Gang, X.
- Affiliations
- First Hospital of Jilin University (CN)
- Jilin University (CN)
- Corresponding author
- Wang, Guixia
- Gang, Xiaokun
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-02-07
- Volume
- 10
- Pages
- 49-49
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6374553
- OpenAlex
- W2912866666
- Cited by
- 36
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 2 · 2014: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- Turner syndrome, glucose metabolism, diabetes mellitus, insulin secretion, insulin sensitivity, obesity, autoimmunity, growth hormone, sex hormone replacement therapy, X chromosome loss, genetic susceptibility
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