NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production

Gonçalves, Virginia M.; Matteucci, Kely C.; Buzzo, Carina L.; Miollo, Bruna H.; Ferrante, Danny; Torrecilhas, Ana C.; Rodrigues, Mauricio M.; Alvarez, Jose M.; Bortoluci, Karina R.

doi:10.1371/journal.pntd.0002469

Cited by 123Inflammasome and immune disordersTrypanosoma species research and implicationsImmune Response and Inflammation

NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production

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Gonçalves, Virginia M., Matteucci, Kely C., Buzzo, Carina L., Miollo, Bruna H., Ferrante, Danny, Torrecilhas, Ana C., Rodrigues, Mauricio M., Alvarez, Jose M. +1 more·2013·PLoS Neglected Tropical Diseases

DOI 10.1371/journal.pntd.0002469PMC PMC3789781

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Abstract

Trypanosoma cruzi (T. cruzi) is an intracellular protozoan parasite and the etiological agent of Chagas disease, a chronic infectious illness that affects millions of people worldwide. Although the role of TLR and Nod1 in the control of T. cruzi infection is well-established, the involvement of inflammasomes remains to be elucidated. Herein, we demonstrate for the first time that T. cruzi infection induces IL-1β production in an NLRP3- and caspase-1-dependent manner. Cathepsin B appears to be required for NLRP3 activation in response to infection with T. cruzi, as pharmacological inhibition of cathepsin B abrogates IL-1β secretion. NLRP3(-/-) and caspase1(-/-) mice exhibited high numbers of T. cruzi parasites, with a magnitude of peak parasitemia comparable to MyD88(-/-) and iNOS(-/-) mice (which are susceptible models for T. cruzi infection), indicating the involvement of NLRP3 inflammasome in the control of the acute phase of T. cruzi infection. Although the inflammatory cytokines IL-6 and IFN-γ were found in spleen cells from NLRP3(-/-) and caspase1(-/-) mice infected with T. cruzi, these mice exhibited severe defects in nitric oxide (NO) production and an impairment in macrophage-mediated parasite killing. Interestingly, neutralization of IL-1β and IL-18, and IL-1R genetic deficiency demonstrate that these cytokines have a minor effect on NO secretion and the capacity of macrophages to control T. cruzi infection. In contrast, inhibition of caspase-1 with z-YVAD-fmk abrogated NO production by WT and MyD88(-/-) macrophages and rendered them as susceptible to T. cruzi infection as NLRP3(-/-) and caspase-1(-/-) macrophages. Taken together, our results demonstrate a role for the NLRP3 inflammasome in the control of T. cruzi infection and identify NLRP3-mediated, caspase-1-dependent and IL-1R-independent NO production as a novel effector mechanism for these innate receptors.

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The master regulator Caspase is associated mainly with regulating the reduction of the load of intracellular parasites, induction of nitric oxide production, increasing the level of CD4 and CD8+ T-cells, secretion of IFNγ, and control of trypanosome infection by macrophages.
“Remarkably, the master regulator Caspase, which is a family of protease enzymes, is associated mainly with regulating the reduction of the load of intracellular parasites, induction of nitric oxide production, increasing the level of CD4 and CD8+ T-cells, secretion of IFNγ, and control of trypanosome infection by macrophages (Gonçalves et al., 2013).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Gonçalves et al., 2013
The Results section ('NLRP3-dependent NO secretion is critical for T. cruzi killing by macrophages'; page not supplied) reports that caspase-1-deficient macrophages produce less NO and harbor more intracellular parasites than wild-type macrophages. The paper does not show that caspase-1 increases CD4+ or CD8+ T-cell levels. Its Results on acute infection report substantial IFN-γ secretion even in caspase-1-deficient mice, although less than in wild-type mice, so IFN-γ is not established as the principal mechanism described in the claim. (LLM, conf=0.88)
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Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development
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Inhibition of poly(ADP-ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite
Larrea, S. C. V., Haikarainen, T., Narwal, M., Schlesinger, M., Venkannagari, H., Flawiá, M. M., Villamil, S. H. F., & Lehtiö, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046063 · Cited by 26 · see citing works
Role of endogenous IFN- gamma in macrophage programming induced by IL-12 and IL-18
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Evaluation of pyroptosis in macrophages using cytosolic delivery of purified flagellin
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Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
Man, S. M., Karki, R., & Kanneganti, T. (2017) · Immunological Reviews · doi:10.1111/imr.12534 · Cited by 1,659 · see citing works
How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1
Keyel, P. A. (2014) · Cytokine · doi:10.1016/j.cyto.2014.03.007 · Cited by 175 · see citing works
Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action
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Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
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How Inflammasomes Inform Adaptive Immunity
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Inflammasomes in host response to protozoan parasites
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ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart
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Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation
Wang, L., Chen, Y., Li, X., Zhang, Y., Gulbins, E., & Zhang, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.12302 · Cited by 111 · see citing works
Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis
Chen, Y., Li, X., Boini, K. M., Pitzer, A. L., Gulbins, E., Zhang, Y., & Li, P. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.11.012 · Cited by 105 · see citing works
PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection
Shio, M. T., Christian, J. G., Jung, J. Y., Chang, K. P., & Olivier, M. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003868 · Cited by 97 · see citing works
Inflammasome: A Double-Edged Sword in Liver Diseases
Luan, J., & Ju, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02201 · Cited by 96 · see citing works
Proteomic analysis reveals different composition of extracellular vesicles released by two Trypanosoma cruzi strains associated with their distinct interaction with host cells
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Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections
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Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders
Wang, Z., Hu, W., Lu, C., Ma, Z., Jiang, S., Gu, C., Acuña-Castroviejo, D., & Yang, Y. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311916 · Cited by 73 · see citing works
Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy
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Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors
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Global Metabolomic Profiling of Acute Myocarditis Caused by Trypanosoma cruzi Infection
Gironès, N., Carbajosa, S., Guerrero, N. A., Poveda, C., Chillón-Marinas, C., & Fresno, M. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003337 · Cited by 66 · see citing works
NLR proteins and parasitic disease
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Reassessing the Evolutionary Importance of Inflammasomes
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Innate immunomodulation to trypanosomatid parasite infections
Dos-Santos, A. L. A., Carvalho‐Kelly, L. F., Dick, C. F., & Meyer‐Fernandes, J. R. (2016) · Experimental Parasitology · doi:10.1016/j.exppara.2016.05.005 · Cited by 61 · see citing works
Cell type-specific roles of NLRP3, inflammasome-dependent and -independent, in host defense, sterile necroinflammation, tissue repair, and fibrosis
Honda, T. S. B., Ku, J., & Anders, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1214289 · Cited by 60 · see citing works
Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4
Chaves, M. M., Sinflorio, D. A., Thorstenberg, M. L., Martins, M. D. A., Moreira-Souza, A. C. A., Rangel, T. P., Silva, C. L. M., Bellio, M., Canetti, C. D. A., & Coutinho‐Silva, R. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007887 · Cited by 57 · see citing works
Caspase-1/ASC Inflammasome-Mediated Activation of IL-1β–ROS–NF-κB Pathway for Control of Trypanosoma cruzi Replication and Survival Is Dispensable in NLRP3−/− Macrophages
Dey, N., Sinha, M., Gupta, S., Gonzalez, M. N., Fang, R., Endsley, J. J., Luxon, B. A., & Garg, N. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111539 · Cited by 56 · see citing works
New Insights into the Immunobiology of Mononuclear Phagocytic Cells and Their Relevance to the Pathogenesis of Cardiovascular Diseases
Sanmarco, L., Eberhardt, N., Ponce, N., Cano, R., Bonacci, G., & Aoki, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01921 · Cited by 46 · see citing works
NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection
Wang, X., Gong, P., Zhang, X., Li, S., Lu, X.-Y., Zhao, C., Yu, Q., Wei, Z., Yang, Y., Liu, Q., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01791 · Cited by 51 · see citing works
Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse
Cai, S., Ge, M., Mennone, A., Hoque, R., Ouyang, X., & Boyer, J. L. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.12.008 · Cited by 51 · see citing works
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Davanso, M. R., Crisma, A. R., Braga, T. T., Masi, L. N., do Amaral, C. L., Leal, V. N. C., de Lima, D. S., Patente, T. A., Barbuto, J. A. M., Corrêa‐Giannella, M. L., et al. (2020) · Clinical Science · doi:10.1042/cs20201348 · Cited by 50 · see citing works
Signaling pathways that regulate Trypanosoma cruzi infection and immune response
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Inflammasome Activation in Response to Intracellular Protozoan Parasites
de Carvalho, R. A., & Zamboni, D. S. (2020) · Trends in Parasitology · doi:10.1016/j.pt.2020.02.006 · Cited by 49 · see citing works
A Two-Component DNA-Prime/Protein-Boost Vaccination Strategy for Eliciting Long-Term, Protective T Cell Immunity against Trypanosoma cruzi
Gupta, S., & Garg, N. J. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004828 · Cited by 48 · see citing works
Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection
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The role of NLRP3 inflammasome in type 2 inflammation related diseases
Xu, S., Wang, D., Tan, L., & Lu, J. (2024) · Autoimmunity · doi:10.1080/08916934.2024.2310269 · Cited by 43 · see citing works
Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage
Buzzo, C. D. L., Medina, T. D. S., Branco, L. M., Lage, S. L., Ferreira, L. C. D. S., Amarante-Mendes, G. P., Hottiger, M. O., Carvalho, D. D. D., & Bortoluci, K. R. (2017) · Scientific Reports · doi:10.1038/srep41686 · Cited by 42 · see citing works
Self-citation
Chagas Disease: Still Many Unsolved Issues
Alvarez, J., Fonseca, R., da Silva, H. B., Marinho, C. R. F., Bortoluci, K. R., Sardinha, L. R., Epiphânio, S., & Lima, M. R. D. (2014) · Mediators of Inflammation · doi:10.1155/2014/912965 · Cited by 41 · see citing works
Self-citation
Mammalian Target of Rapamycin Inhibition in Trypanosoma cruzi-Infected Macrophages Leads to an Intracellular Profile That Is Detrimental for Infection
Márquez, J. D. R., Ana, Y., Baigorrí, R. E., Stempin, C. C., & Cerbán, F. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00313 · Cited by 41 · see citing works
Programmed Cell Death in the Evolutionary Race against Bacterial Virulence FactorsPreprint
Lacey, C. A., & Miao, E. A. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036459 · Cited by 41 · see citing works
Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed
Mekonnen, Y. A., Gültas, M., Effa, K., Hanotte, O., & Schmitt, A. O. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01095 · Cited by 37 · see citing works
“Remarkably, the master regulator Caspase, which is a family of protease enzymes, is associated mainly with regulating the reduction of the load of intracellular parasites, induction of nitric oxide production, increasing the level of CD4 and CD8+ T-cells, secretion of IFNγ, and control of trypanosome infection by macr…”
Background
Host‐parasite dynamics in Chagas disease from systemic to hyper‐local scales
Pérez‐Mazliah, D., Ward, A. I., & Lewis, M. D. (2020) · Parasite Immunology · doi:10.1111/pim.12786 · Cited by 37 · see citing works
Trichomonas vaginalis induces IL‐1β production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux
Gu, N. Y., Kim, J., Han, I., Im, S., Seo, M., Chung, Y., & Ryu, J. (2016) · The Prostate · doi:10.1002/pros.23178 · Cited by 36 · see citing works
Virulence of Trypanosoma cruzi Strains Is Related to the Differential Expression of Innate Immune Receptors in the Heart
Queiroga, T. B. D., Pereira, N. D. S., da Silva, D. D., Andrade, C. D. M., Júnior, R. F. D. A., Brito, C. R. D. N., Galvão, L. M. D. C., da Câmara, A. C. J., Nascimento, M. S. L., & Guedes, P. M. D. M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.696719 · Cited by 35 · see citing works
NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection
Paroli, A. F., Gonzalez, P. V., Díaz-Luján, C. M., Onofrio, L. I., Arocena, A. R., Cano, R. C., Silva, E. A. C., & Gea, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00913 · Cited by 33 · see citing works
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients
Pereira, N. D. S., Queiroga, T. B. D., Nunes, D. F., Andrade, C. D. M., Nascimento, M. S. L., Matta, M. A. D. V., da Câmara, A. C. J., Galvão, L. M. D. C., Guedes, P. M. D. M., & Chiari, É. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006589 · Cited by 33 · see citing works
NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri
Kim, J.-H., Sohn, H., Yoo, J.-K., Kang, H., Seong, G.-S., Chwae, Y., Kim, K. H., Park, S., & Shin, H. (2016) · Infection and Immunity · doi:10.1128/iai.00275-16 · Cited by 32 · see citing works
Host inflammatory responses to intracellular invaders: Review study
Chandra, R. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117084 · Cited by 30 · see citing works
NLRP3 played a role in Trichinella spiralis-triggered Th2 and regulatory T cells response
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Trypanosoma cruzi Evades the Protective Role of Interferon-Gamma-Signaling in Parasite-Infected Cells
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Xanthine oxidoreductase activation is implicated in the onset of metabolic arthritis
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Ebi3 Prevents Trypanosoma cruzi-Induced Myocarditis by Dampening IFN-γ-Driven Inflammation
Medina, T. D. S., de Oliveira, G. G., Silva, M. C., David, B. A., Silva, G. K., da Fonseca, D. M., Sesti‐Costa, R., Frade, A. F., Baron, M., Ianni, B. M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01213 · Cited by 22 · see citing works
NOD-like receptors in fish: evolution, structure, immune signaling, and targeting for aquaculture vaccine adjuvants
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Frontline Science: Autophagy is a cell autonomous effector mechanism mediated by NLRP3 to control Trypanosoma cruzi infection
Matteucci, K. C., Pereira, G. J. S., Weinlich, R., & Bortoluci, K. R. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.hi1118-461r · Cited by 20 · see citing works
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Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy
Fernández‐Ortiz, M., Sayed, R. K. A., Montoya, Y. R., Rol, M. A., Fernández‐Martínez, J., Ramírez‐Casas, Y., Florido, J., Rusanova, I., Escames, G., & Acuña-Castroviejo, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126846 · Cited by 19 · see citing works
Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy
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Molecular regulation of NLRP3 inflammasome activation during parasitic infection
Alonaizan, R. (2024) · Bioscience Reports · doi:10.1042/bsr20231918 · Cited by 18 · see citing works
Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites
Wang, S., Moreau, F., & Chadee, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.900553 · Cited by 15 · see citing works
The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication
Pacheco, A. D. O. L., Vicentini, G., Matteucci, K. C., Rosa‐Ribeiro, R., Weinlich, R., & Bortoluci, K. R. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ab1118-416rr · Cited by 15 · see citing works
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Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways
Wozniak, J. M., Silva, T. A., Thomas, D. M., Siqueira-Neto, J. L., McKerrow, J. H., Gonzalez, D. J., & Calvet, C. M. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007980 · Cited by 15 · see citing works
STING Signaling Drives Production of Innate Cytokines, Generation of CD8+ T Cells and Enhanced Protection Against Trypanosoma cruzi Infection
Vieira, R. D. S., Nascimento, M. S., Noronha, I. H., Vasconcelos, J. R., Benvenuti, L. A., Barber, G. N., Câmara, N. O. S., Kalil, J. E., Cunha‐Neto, E., & Almeida, R. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775346 · Cited by 15 · see citing works
MGL1 Receptor Plays a Key Role in the Control of T. cruzi Infection by Increasing Macrophage Activation through Modulation of ERK1/2, c-Jun, NF-κB and NLRP3 Pathways
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Trypanosoma cruziInfection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response
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Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers
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The First Contact of Human Dendritic Cells With Trypanosoma cruzi Reveals Response to Virus as an Unexplored Central Pathway
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Parasite-Derived Neurotrophic Factor/trans-Sialidase of Trypanosoma cruzi Links Neurotrophic Signaling to Cardiac Innate Immune Response
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Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling
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Role of inflammasomes in innate host defense against Entamoeba histolytica
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Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi strains unveil a role for fibroblasts in neutrophil recruitment and activation
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IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa
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Mixed signals – howTrypanosoma cruziexploits host-cell communication and signaling to establish infection
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Endothelial nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis (851.5)
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Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia
Fu, K. Y., Zamudio, R., Henderson-Frost, J., Almuedo-Riera, A., Steinberg, H. E., Clipman, S. J., Duran, G., Marcus, R. R., Crawford, T., Alyesh, D. M., et al. (2017) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0015-2017 · Cited by 10 · see citing works
Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis
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Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice
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Authors: Gonçalves, V. M., Matteucci, K. C., Buzzo, C. L., Miollo, B. H., Ferrante, D., Torrecilhas, A. C., Rodrigues, M. M., Alvarez, J. M., & Bortoluci, K. R.
Affiliations: Universidade Federal de São Paulo (BR)
Instituto de Ciências Ambientais, Químicas e Farmacêuticas (BR)
Corresponding author: Bortoluci, Karina R.
ORCID: Matteucci, Kely C.
Torrecilhas, Ana C.
Rodrigues, Mauricio M.
Bortoluci, Karina R.
Venue: PLoS Neglected Tropical Diseases
Publisher: Public Library of Science (PLoS)
Published: 2013-10-03
Volume: 7
Issue: 10
Pages: e2469
ISSN: 1935-2727 (ISSN-L)
1935-2735
DOI: 10.1371/journal.pntd.0002469
PMC: PMC3789781
OpenAlex: W2140577495
Cited by: 123
References: 68
Citations by year: 2026: 4 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 15 · 2019: 14 · 2018: 17 · 2017: 12 · 2016: 14 · 2015: 6 · 2014: 14
FWCI: 5.08
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS neglected tropical diseases (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Americanae (AECID Library) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo (08/50958-8)
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: Trypanosoma cruzi, Chagas disease, NLRP3 inflammasome, caspase-1, nitric oxide production, IL-1β, cathepsin B, innate immunity, MyD88, IL-18, parasitemia control
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Disease Models, Animal, Female, Gene Expression Regulation, Nitric Oxide, Trypanosoma cruzi, Chagas Disease, Mice, Knockout, Caspase 1, Mice, Interleukin-1beta, Host-Pathogen Interactions

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NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production

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