Nlrp3: An immune sensor of cellular stress and infection

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113 · see citing works

Intracellular NOD-like Receptors in Host Defense and Disease

Kanneganti, T., Lamkanfi, M., & Núñez, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.10.002 · Cited by 1,056 · see citing works

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980 · see citing works

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

Muruve, D. A., Pétrilli, V., Zaiss, A. K., White, L. R., Clark, S. A., Ross, P. J., Parks, R. J., & Tschopp, J. (2008) · Nature · doi:10.1038/nature06664 · Cited by 936 · see citing works

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 922 · see citing works

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

Lachmann, H. J., Kone-Paut, I., Kuemmerle-Deschner, J. B., Leslie, K. S., Hachulla, E., Quartier, P., Gitton, X., Widmer, A., Patel, N., & Hawkins, P. N. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810787 · Cited by 869 · see citing works

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

Thomas, P. G., Dash, P., Aldridge, J. R., Ellebedy, A. H., Reynolds, C., Funk, A. J., Martin, W. J., Lamkanfi, M., Webby, R. J., Boyd, K. L., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.006 · Cited by 749 · see citing works

Chronic Infantile Neurological Cutaneous and Articular Syndrome Is Caused by Mutations in CIAS1, a Gene Highly Expressed in Polymorphonuclear Cells and Chondrocytes

Feldmann, J., Prieur, A., Quartier, P., Berquin, P. C., Dogniaux, S., Cortis, E., Hamel‐Teillac, D., Fischer, A., & Basile, G. D. S. (2002) · The American Journal of Human Genetics · doi:10.1086/341357 · Cited by 737 · see citing works

Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

Kanneganti, T., Body–Malapel, M., Amer, A. O., Park, J., Whitfield, J. R., Franchi, L., Taraporewala, Z. F., Miller, D. J., Patton, J. T., Inohara, N., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607594200 · Cited by 706 · see citing works

Inflammasome recognition of influenza virus is essential for adaptive immune responses

Ichinohe, T., Lee, H. K., Ogura, Y., Flavell, R. A., & Iwasaki, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081667 · Cited by 682 · see citing works

Interleukin-1–Receptor Antagonist in the Muckle–Wells Syndrome

Hawkins, P. N., Lachmann, H. J., & McDermott, M. F. (2003) · New England Journal of Medicine · doi:10.1056/nejm200306193482523 · Cited by 654 · see citing works

Pathogen recognition in the innate immune response

Kumar, H., Kawai, T., & Akira, S. (2009) · Biochemical Journal · doi:10.1042/bj20090272 · Cited by 586 · see citing works

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

Martinon, F., Agostini, L., Meylan, E., & Tschopp, J. (2004) · Current Biology · doi:10.1016/j.cub.2004.10.027 · Cited by 579 · see citing works

Efficacy and safety of rilonacept (interleukin‐1 trap) in patients with cryopyrin‐associated periodic syndromes: Results from two sequential placebo‐controlled studies

Hoffman, H. M., Throne, M. L., Amar, N. J., Sebai, M., Kivitz, A. J., Kavanaugh, A., Weinstein, S. P., Belomestnov, P., Yancopoulos, G. D., Stahl, N., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23687 · Cited by 577 · see citing works

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

Hise, A. G., Tomalka, J. A., Ganesan, S., Patel, K., Hall, B. A., Brown, G. D., & Fitzgerald, K. A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.002 · Cited by 568 · see citing works

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

Hoffman, H. M., Rosengren, S., Boyle, D. L., Cho, J. Y., Nayar, J., Mueller, J. L., Anderson, J. P., Wanderer, A. A., & Firestein, G. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17401-1 · Cited by 552 · see citing works

The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D. (2007) · Current Biology · doi:10.1016/j.cub.2007.05.074 · Cited by 544 · see citing works

Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

Kummer, J. A., Broekhuizen, R., Everett, H., Agostini, L., Kuijk, L., Martinon, F., Bruggen, R. V., & Tschopp, J. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a7101.2006 · Cited by 531 · see citing works

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

Kanneganti, T., Lamkanfi, M., Kim, Y., Chen, G., Park, J., Franchi, L., Vandenabeele, P., & Núñez, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.008 · Cited by 526 · see citing works

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

Villani, A., Lemire, M., Fortin, G., Louis, E. J., Silverberg, M. S., Collette, C., Baba, N., Libioulle, C., Bélaïche, J., Bitton, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.285 · Cited by 526 · see citing works

A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

Meng, G., Zhang, F., Fuss, I. J., Kitani, A., & Strober, W. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.012 · Cited by 365 · see citing works

Inflammasomes: guardians of cytosolic sanctity

Lamkanfi, M., & Dixit, V. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00730.x · Cited by 364 · see citing works

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity

Brydges, S. D., Mueller, J. L., McGeough, M. D., Pena, C. A., Misaghi, A., Gandhi, C., Putnam, C. D., Boyle, D. L., Firestein, G. S., Horner, A. A., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.005 · Cited by 339 · see citing works

Cutting Edge: <i>Candida albicans</i> Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

Joly, S., Ma, N., Sadler, J. J., Soll, D. R., Cassel, S. L., & Sutterwala, F. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901323 · Cited by 296 · see citing works

Cryopyrin-induced Interleukin 1β Secretion in Monocytic Cells

Dowds, T. A., Masumoto, J., Li, Z., Inohara, N., & Núñez, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401178200 · Cited by 235 · see citing works

IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients

Stack, J. H., Beaumont, K. C., Larsen, P. D., Straley, K. S., Henkel, G., Randle, J. C. R., & Hoffman, H. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2630 · Cited by 191 · see citing works

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome

Lamkanfi, M., Malireddi, R. K. S., & Kanneganti, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023689 · Cited by 147 · see citing works

Osteoblasts Express NLRP3, a Nucleotide-Binding Domain and Leucine-Rich Repeat Region Containing Receptor Implicated in Bacterially Induced Cell Death

McCall, S. H., Sahraei, M., Young, A. B., Worley, C. S., Duncan, J. A., Ting, J. P.-Y., & Marriott, I. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.071002 · Cited by 90 · see citing works

The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation

Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539 · see citing works

Role of neuroinflammation in neurodegeneration development

Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

Gurung, P., Anand, P., Malireddi, R. K. S., Walle, L. V., Opdenbosch, N. V., Dillon, C. P., Weinlich, R., Green, D. R., Lamkanfi, M., & Kanneganti, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302839 · Cited by 558 · see citing works

Oxidative stress and inflammation interactions in human obesity

Bondia‐Pons, I., Ryan, L., & Martínez, J. A. (2012) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0154-2 · Cited by 415 · see citing works

IL-18 production downstream of the NLRP3 inflammasome confers protection against colorectal tumor formation

Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M., & Kanneganti, T.-D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002046 · Cited by 411 · see citing works

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

Luo, B., Li, B., Wang, W., Liu, X., Xia, Y., Zhang, C., Zhang, M., Zhang, Y., & An, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104771 · Cited by 408 · see citing works

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

Robinson, N., Ganesan, R., Hegedűs, C., Kovács, K. É., Kufer, T. A., & Virág, L. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101239 · Cited by 370 · see citing works

Effect of Particulate Matter Air Pollution on Cardiovascular Oxidative Stress Pathways

Rao, X., Zhong, J., Brook, R. D., & Rajagopalan, S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7394 · Cited by 360 · see citing works

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

Zhang, Y., Liu, L., Liu, Y.-Z., Shen, X.-L., Wu, T.-Y., Zhang, T., Wang, W., Wang, Y.-X., & Jiang, C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv006 · Cited by 323 · see citing works

Alum adjuvant: some of the tricks of the oldest adjuvant

Kool, M., Fierens, K., & Lambrecht, B. N. (2011) · Journal of Medical Microbiology · doi:10.1099/jmm.0.038943-0 · Cited by 321 · see citing works

Targeting Interleukin-1 in Heart Disease

Tassell, B. W. V., Toldo, S. A., Mezzaroma, E., & Abbate, A. (2013) · Circulation · doi:10.1161/circulationaha.113.003199 · Cited by 306 · see citing works

The NLRP3 inflammasome: Contributions to intestinal homeostasis

Zaki, M. H., Lamkanfi, M., & Kanneganti, T.-D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.02.002 · Cited by 290 · see citing works

NLRP3: A promising therapeutic target for autoimmune diseases

Shen, H., Yang, Y., Meng, X. L., Luo, X., Li, X., Shuai, Z., Ye, D., & Pan, H. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.01.020 · Cited by 272 · see citing works

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

Kesavardhana, S., & Kanneganti, T. (2017) · International Immunology · doi:10.1093/intimm/dxx018 · Cited by 254 · see citing works

Cytokine-Induced Modulation of Colorectal Cancer

Mager, L. F., Wasmer, M.-H., Rau, T. T., & Krebs, P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00096 · Cited by 215 · see citing works

NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model

Su, W., Zhang, Y., Chen, Y., Gong, H., Lian, Y., Wei, P., Liu, Y., Wang, Y., You, Z., Feng, S.-J., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.018 · Cited by 214 · see citing works

NOD-like receptors and the innate immune system: Coping with danger, damage and death

Kersse, K., Bertrand, M. J. M., Lamkanfi, M., & Vandenabeele, P. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.09.003 · Cited by 202 · see citing works

Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors

Zhang, Y., Liu, L., Peng, Y., Liu, Y., Wu, T., Shen, X., Zhou, J., Sun, D., Huang, A., Wang, X., et al. (2014) · CNS Neuroscience &amp; Therapeutics · doi:10.1111/cns.12170 · Cited by 200 · see citing works

Endothelial Mechanotransduction, Redox Signaling and the Regulation of Vascular Inflammatory Pathways

Chatterjee, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00524 · Cited by 198 · see citing works

Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus

Frank, M. G., Hershman, S. A., Weber, M. D., Watkins, L. R., & Maier, S. F. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.006 · Cited by 183 · see citing works

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

Frank, M. G., Nguyen, K., Ball, J. B., Hopkins, S., Kelley, T., Baratta, M. V., Fleshner, M., & Maier, S. F. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.007 · Cited by 176 · see citing works

Deregulated inflammasome signaling in disease

Lamkanfi, M., Walle, L. V., & Kanneganti, T. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01042.x · Cited by 154 · see citing works

Rosuvastatin Alleviates Diabetic Cardiomyopathy by Inhibiting NLRP3 Inflammasome and MAPK Pathways in a Type 2 Diabetes Rat Model

Luo, B., Li, B., Wang, W., Liu, X., Liu, X., Xia, Y., Zhang, C., Zhang, Y., Zhang, M., & An, F. (2013) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-013-6498-1 · Cited by 150 · see citing works

NLRP12 in innate immunity and inflammation

Tuladhar, S., & Kanneganti, T. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100887 · Cited by 145 · see citing works

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

Malireddi, R. K. S., Ippagunta, S. K., Lamkanfi, M., & Kanneganti, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001512 · Cited by 139 · see citing works

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

Frank, M. G., Weber, M. D., Fonken, L. K., Hershman, S. A., Watkins, L. R., & Maier, S. F. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.10.009 · Cited by 133 · see citing works

Inflammasomes and its importance in viral infections

Shrivastava, G., León‐Juárez, M., García‐Cordero, J., Meza-Sánchez, D. E., & Cedillo‐Barrón, L. (2016) · Immunologic Research · doi:10.1007/s12026-016-8873-z · Cited by 130 · see citing works

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway

Yin, Y., Zhou, Z., Liu, W., Chang, Q., Sun, G., & Dai, Y. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.01.001 · Cited by 130 · see citing works

Principles of inflammasome priming and inhibition: implications for psychiatric disorders

Herman, F. J., & Pasinetti, G. M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.010 · Cited by 115 · see citing works

Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes

Kong, F., Ye, B., Lü, L., Cai, X., Huang, W., & Huang, Z. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.04.043 · Cited by 123 · see citing works

Pyroptosis-Induced Inflammation and Tissue Damage

Wei, Y., Yang, L., Pandeya, A., Cui, J., Zhang, Y., & Li, Z. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167301 · Cited by 127 · see citing works

Odontoblast physiology

Bleicher, F. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.12.012 · Cited by 109 · see citing works

Role of the Nlrp3 Inflammasome in Microbial Infection

Anand, P., Malireddi, R. K. S., & Kanneganti, T. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00012 · Cited by 104 · see citing works

Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice

Tastan, B., Arioz, B. I., Tüfekçi, K. U., Tarakcioglu, E., Gonul, C. P., Genç, K., & Genç, Ş. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.737065 · Cited by 100 · see citing works

Mutations of the Listeria monocytogenes PeptidoglycanN-Deacetylase andO-Acetylase Result in Enhanced Lysozyme Sensitivity, Bacteriolysis, and Hyperinduction of Innate Immune Pathways

Rae, C. S., Geissler, A. L., Adamson, P. C., & Portnoy, D. A. (2011) · Infection and Immunity · doi:10.1128/iai.00077-11 · Cited by 98 · see citing works

Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection

Lupfer, C. R., Anand, P., Liu, Z., Stokes, K. L., Vogel, P., Lamkanfi, M., & Kanneganti, T. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004410 · Cited by 97 · see citing works

Inflammasomes and type 2 diabetes: An updated systematic review

Sepehri, Z., Kiani, Z., Afshari, M., Kohan, F., Dalvand, A., & Ghavami, S. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.10.010 · Cited by 95 · see citing works

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status

Jabaut, J., Ather, J. L., Taracanova, A., Poynter, M. E., & Ckless, K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.025 · Cited by 89 · see citing works

Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases

Sandhu, J. K., & Kulka, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031093 · Cited by 85 · see citing works

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

Suryavanshi, S. V., Kovalchuk, I., & Kovalchuk, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613613 · Cited by 86 · see citing works

Induction and function of virus-specific CD4+ T cell responses

Whitmire, J. K. (2011) · Virology · doi:10.1016/j.virol.2010.12.015 · Cited by 80 · see citing works

The NLRP 3 inflammasome: role in airway inflammation

Im, H., & Ammit, A. J. (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12206 · Cited by 80 · see citing works

Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents

Manavi, M. A., Nasab, M. H. F., Jafari, R. M., & Dehpour, A. R. (2024) · Journal of Chemotherapy · doi:10.1080/1120009x.2023.2300217 · Cited by 78 · see citing works

Inflammasome activation in obesity-related inflammatory diseases and autoimmunity.

Lukens, J. R., Dixit, V. D., & Kanneganti, T. (2011) · PubMed · Cited by 78 · see citing works

Pyrin- and CARD-only Proteins as Regulators of NLR Functions

Le, H. T., & Harton, J. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00275 · Cited by 75 · see citing works

NAFLD and HBV interplay - related mechanisms underlying liver disease progression

Tourkochristou, E., Assimakopoulos, S. F., Thomopoulos, K., Marangos, M., & Triantos, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.965548 · Cited by 70 · see citing works

Activation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infection

Figueroa, G., Torres, J., Sánchez-Zauco, N. A., Contreras‐Ramos, A., Álvarez‐Arellano, L., & Maldonado‐Bernal, C. (2015) · Innate Immunity · doi:10.1177/1753425915619475 · Cited by 70 · see citing works

Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease

Carter, C. (2017) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-170017 · Cited by 70 · see citing works

The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway

Xie, L., Gu, Z., Liu, H., Jia, B., Wang, Y., Cao, M., Song, R., Zhang, Z., & Bian, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01251 · Cited by 70 · see citing works

Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway

Li, X., Li, Z., Li, B., Zhu, X., & Lai, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116773 · Cited by 66 · see citing works

Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation

Frank, M. G., Fonken, L. K., Watkins, L. R., & Maier, S. F. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.063 · Cited by 66 · see citing works

The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review

Ragino, Y. I., Stakhneva, E. M., Polonskaya, Y. V., & Kashtanova, E. V. (2020) · Biomolecules · doi:10.3390/biom10030374 · Cited by 66 · see citing works

Transcriptomic and Proteomic Analyses Reveal Key Innate Immune Signatures in the Host Response to the Gastrointestinal Pathogen Campylobacter concisus

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The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury

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