Effect of atorvastatin on antibody, interleukin-4 and gamma-interferon production in mice immunized with egg albumin.
Abstract
Three-hydroxy-3-methylglutaryl CoA reductase inhibitors, also known as statins, are widely used as the drug of choice for the treatment of hyperlipidemia. However, actions beyond that of simply lowering cholesterol levels have been reported. This study aims at evaluating the effect of atorvastatin on antibody interleukin-4 and gamma-interferon production in mice immunized with egg albumin. Antibody levels were determined by an enzyme linked immunosorbent assay and cytokine transcripts by reverse transcriptase-polymerase chain reaction. Results indicated that repeated daily doses of 40 mg/Kg body weight of atorvastatin following immunization suppressed the antibody response in mice to egg albumin. Moreover, a decline in interleukin-4 and gamma-interferon transcripts was observed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Our group previously reported that atorvastatin suppresses certain aspects of both humoral and cell-mediated immunity in mice challenged with egg albumin, including suppression of IFN-γ and IL-4 production.
“Our group has previously reported a suppression of certain aspects of both the humoral and the cell-mediated branches of immunity in mice challenged with egg albumin upon treatment with atorvastatin (El-Haibi et al., 2006). We detected a suppression of IFN-γ and IL-4 production.”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as El-Haibi et al., 2006
Atorvastatin at 40 mg/Kg is the minimum effective immunomodulatory dose in BALB/c mice.
“Atorvastatin injections were also administered intraperitoneally with each injection consisting of 40 mg/Kg, the minimum effective immunomodulatory dose in BALB/c mice as reported in our previous studies (El-Haibi et al., 2006).”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as El-Haibi et al., 2006
Atorvastatin has an enhanced graft longevity effect in mice and human transplant recipients, potentially due to its immunomodulatory properties.
“Members of our group have also reported an enhanced graft longevity effect for atorvastatin, one of the most commonly used statins, in mice and in human transplant recipients; this is potentially due to atorvastatin’s immunomodulatory properties (El-Haibi et al., 2006; Rahal et al., 2012a,b; Zeidan et al., 2013).”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as El-Haibi et al., 2006
In previous studies, atorvastatin reduced IFN-γ when mice were challenged with albumin but not when they received skin allografts.
“In our previous studies on BALB/c mice atorvastatin reduced the expression of IFN-γ when mice were challenged with albumin (El-Haibi et al., 2006) but not when they received skin allografts from C57BL/6 mice (Zeidan et al., 2013).”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as El-Haibi et al., 2006
Atorvastatin at 40 mg/Kg is not lethal to mice by itself.
“Moreover, these previous studies have shown that this dose of atorvastatin is not lethal to the mice by itself.”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as El-Haibi et al., 2006
Cites
Statins as a newly recognized type of immunomodulator.
Kwak, B., Mulhaupt, F., Myit, S., & Mach, F. (2000) · Nature Medicine · doi:10.1038/82219 · Cited by 1,383 · see citing works
Youssef, S., Stüve, O., Patarroyo, J. C., Ruiz, P. J., Radosevich, J. L., Hur, E. M., Bravo, M., Mitchell, D. J., Sobel, R. A., Steinman, L., et al. (2002) · Nature · doi:10.1038/nature01158 · Cited by 1,098 · see citing works
Statins: mechanism of action and effects
Stancu, C., & Sima, A. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00172.x · Cited by 911 · see citing works
The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection
Sayegh, M. H., & Turka, L. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806183382506 · Cited by 576 · see citing works
Lennernäs, H., & Fager, G. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199732050-00005 · Cited by 527 · see citing works
A novel anti-inflammatory role for simvastatin in inflammatory arthritis.
Leung, B. P., Sattar, N., Crilly, A., Prach, M., McCarey, D. W., Payne, H., Madhok, R., Campbell, C., Gracie, J. A., Liew, F. Y., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1524 · Cited by 434 · see citing works
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma.
McKay, A., Leung, B. P., McInnes, I. B., Thomson, N. C., & Liew, F. Y. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2903 · Cited by 309 · see citing works
Hakamada‐Taguchi, R., Uehara, Y., Kuribayashi, K., Numabe, A., Saito, K., Negoro, H., Fujita, T., Toyo‐oka, T., & Kato, T. (2003) · Circulation Research · doi:10.1161/01.res.0000101298.76864.14 · Cited by 173 · see citing works
Terasaki, P. I., & Ozawa, M. (2005) · Transplantation · doi:10.1097/01.tp.0000174338.97313.5a · Cited by 168 · see citing works
Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells
Mulhaupt, F. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00515-7 · Cited by 133 · see citing works
Wofsy, D., Mayes, D. C., Woodcock, J., & Seaman, W. E. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.3.1698 · Cited by 117 · see citing works
Comparison of cytokine measurements using ELISA, ELISPOT and semi-quantitative RT-PCR
Favre, N., Bordmann, G., & Rudin, W. (1997) · Journal of Immunological Methods · doi:10.1016/s0022-1759(97)00033-1 · Cited by 115 · see citing works
Statins as Immunomodulatory Agents
Mach, F. (2004) · Circulation · doi:10.1161/01.cir.0000129502.10459.fe · Cited by 112 · see citing works
Chung, H. K., Lee, I. K., Kang, H., Suh, J. M., Kim, H., Park, K. C., Kim, D. W., Kim, Y. K., Ro, H. K., & Shong, M. (2002) · Experimental & Molecular Medicine · doi:10.1038/emm.2002.63 · Cited by 96 · see citing works
Permanent life support by kidneys perfused with a vitrifiable (7.5 molar) cryoprotectant solution.
Kheirabadi, B. S., & Gm, F. (2000) · PubMed · Cited by 48 · see citing works
Variable cyclosporine exposure: a risk factor for chronic allograft nephropathy and graft loss?
He, X., & Johnston, A. E. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2004.04.084 · Cited by 14 · see citing works
HYPERCHOLESTEROLEMIA AND CHRONIC REJECTION OF RENAL ALLOGRAFTS
Blum, C. B. (2001) · Transplantation · doi:10.1097/00007890-200108270-00037 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A Systematic Review of Statin Efficacy in Asthma
Silva, D., Couto, M., Delgado, L., & Moreira, A. M. (2012) · Journal of Asthma · doi:10.3109/02770903.2012.721433 · Cited by 24 · see citing works
Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice
Rahal, E. A., Constantin, W. N., Zeidan, N., & Abdelnoor, A. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01474 · Cited by 14 · see citing works
“We used this dose since it was the lowest to have an immunomodulatory effect in BALB/c mice in our previous studies (El-Haibi et al., 2006).”
BackgroundMethodInfluentialSelf-citationFactors involved in the pathogenesis of psoriasis
Abdelnoor, A. M., & Al-Akl, N. S. (2013) · Advanced Studies in Medical Sciences · doi:10.12988/asms.2013.13008 · Cited by 7 · see citing works
Self-citationHussein, H. M., Al-Khoury, D. K., Abdelnoor, A. M., & Rahal, E. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-48282-2 · Cited by 6 · see citing works
Self-citationRahal, E. A., Chakhtoura, M., Dargham, R. A., Khauli, R. B., Medawar, W. A., & Abdelnoor, A. M. (2012) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2011.653648 · Cited by 6 · see citing works
“We have previously demonstrated that statins depress particular Th1 and Th2 responses in albumin-challenged mice.((33)) These observations may indicate that the enhanced graft longevity seen in the statin-treated group of recipients in the study at hand is likely due to modulation of the immune response.”
BackgroundSelf-citationZeidan, N. (2013) · British Journal of Medicine and Medical Research · doi:10.9734/bjmmr/2013/3338 · Cited by 1 · see citing works
“A dose of 40 mg/kg of AS was used because in a previous study this dose was determined to be the minimum dose that affected the immune response to egg albumin in mice [6].”
BackgroundMethodRahal, E. A. (2012) · IOSR Journal of Pharmacy (IOSRPHR) · doi:10.9790/3013-25105660 · Cited by 1 · see citing works
Self-citation
- Authors
- El-Haibi, C., Rahal, E., Khauli, R. B., & Abdelnoor, A. M.
- Affiliations
- American University of Beirut (LB)
- Venue
- Immunopharmacology and Immunotoxicology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 28
- Issue
- 3
- Pages
- 459-470
- ISSN
- 0892-3973 (ISSN-L)
- 1532-2513
- OpenAlex
- W2021060213
- Cited by
- 7
- References
- 17
- Citations by year
- 2019: 1 · 2015: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunopharmacology and Immunotoxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- atorvastatin, statins, immunomodulation, antibody response, ovalbumin, IL-4, interferon-gamma, cytokine gene expression, hyperlipidemia, immunosuppression
- MeSH terms
- Atorvastatin, Albumins, Animals, Antibody Formation, Dose-Response Relationship, Drug, Egg White, Electrophoresis, Agar Gel, Female, Heptanoic Acids, Immunization Schedule, Interferon-gamma, Mice, Inbred BALB C, Pyrroles, Transcription, Genetic, Interleukin-4, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Reverse Transcriptase Polymerase Chain Reaction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
