The effect of atorvastatin (lipitor) on the duration of survival of allogeneic skin graft and the growth of B16F10 melanoma cells in mice.
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Aims: To evaluate the immunomodulatory effect of using non-cholesterol lowering dose of atorvastatin (AS) on skin allograft survival and on tumor growth in mice.
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Atorvastatin has an enhanced graft longevity effect in mice and human transplant recipients, potentially due to its immunomodulatory properties.
“Members of our group have also reported an enhanced graft longevity effect for atorvastatin, one of the most commonly used statins, in mice and in human transplant recipients; this is potentially due to atorvastatin’s immunomodulatory properties (El-Haibi et al., 2006; Rahal et al., 2012a,b; Zeidan et al., 2013).”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as Zeidan et al., 2013
In previous studies, atorvastatin reduced IFN-γ when mice were challenged with albumin but not when they received skin allografts.
“In our previous studies on BALB/c mice atorvastatin reduced the expression of IFN-γ when mice were challenged with albumin (El-Haibi et al., 2006) but not when they received skin allografts from C57BL/6 mice (Zeidan et al., 2013).”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as Zeidan et al., 2013
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“A dose of 40 mg/kg of AS was used because in a previous study this dose was determined to be the minimum dose that affected the immune response to egg albumin in mice [6].”
BackgroundMethodRahal, E. A., Chakhtoura, M., Dargham, R. A., Khauli, R. B., Medawar, W. A., & Abdelnoor, A. M. (2012) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2011.653648 · Cited by 6 · see citing works
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Research works printed but not linked: 1
- Suzuki J-, Koga N, Kosuge H, Ogawa M, Haraguchi G, Maejima Y, et al. Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts. Transplantation. 2007;83(8):1093-1097.
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Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice
Rahal, E. A., Constantin, W. N., Zeidan, N., & Abdelnoor, A. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01474 · Cited by 14 · see citing works
Self-citation
- Authors
- Zeidan, N.
- Affiliations
- American University of Beirut (LB)
- Corresponding author
- Zeidan, Nabil
- Venue
- British Journal of Medicine and Medical Research
- Publisher
- Sciencedomain International
- Published
- 2013-01-10
- Volume
- 3
- Issue
- 4
- Pages
- 1938-1951
- ISSN
- 2231-0614 (ISSN-L)
- OpenAlex
- W2110137995
- Cited by
- 1
- References
- 39
- Citations by year
- 2015: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Advances in Medicine and Medical Research (publishedVersion)
- Journal of Advances in Medicine and Medical Research (publishedVersion, cc-by)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- atorvastatin, immunomodulation, B16F10 melanoma, tumor growth, statins, graft-versus-tumor effect
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