The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition
Abstract
Objectives: Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints, which is associated with the rise of serum urate content. This study aims to investigate the therapeutic effect of Madecassoside on gouty arthritis and hyperuricemia. Methods: DBA/1 mice were intradermally injected with MSU to stimulate joint inflammation or intraperitoneally injected with MSU to trigger peritonitis. Moreover, ICR mice were exposed to potassium oxonate to stimulate hyperuricemia. Results: Madecassoside repressed MSU-triggered pad swelling, joint 99mTc uptake, and joint inflammation in DBA/1 mice with gouty arthritis. Neutrophil infiltration and IL-1β & IL-6 & MCP-1 secretion was also alleviated in lavage fluids from DBA/1 mice with peritonitis due to Madecassoside treatment. Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation. In hyperuricemic mice, Madecassoside improved renal dysfunction. Serum uric acid, BUN, and creatinine were down-regulated by Madecassoside. Conclusion: These findings indicate that Madecassoside has potential to ameliorate inflammation in both acute gouty arthritis model and peritonitis model, probably via regulating IL-1β and NLRP3 expression. Practical point: Madecassoside also exhibited a urate-lowering effect and a renal protective effect in hyperuricemic mice.
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“madecassoside suppressed MSU‐induced inflammation in mice with gouty arthritis, alleviated neutrophil infiltration and inhibited the secretion of pro‐inflammatory mediators in mice with peritoneal inflammation.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [133]
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Cited by
Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220
Metadata
- Authors
- Lu, X., Zeng, R., Lin, J., Hu, J., Rong, Z., Xu, W., Liu, Z., & Zeng, W.
- Affiliations
- First Affiliated Hospital of Shantou University Medical College (CN)
- Department of Orthopedic Surgery, The First Affiliate Hospital of Shantou University Medical College
- University College London (GB)
- Corresponding author
- Lu, Xiaohui
- Venue
- Immunopharmacology and Immunotoxicology
- Publisher
- Informa UK Limited
- Published
- 2019-03-04
- Volume
- 41
- Issue
- 2
- Pages
- 277-284
- ISSN
- 0892-3973 (ISSN-L)
- 1532-2513
- OpenAlex
- W2945752146
- Cited by
- 30
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 1
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- doi.org/10.1080/policies-text-data-mining (tdm)
- Locations
- Immunopharmacology and Immunotoxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- madecassoside, gout, hyperuricemia, monosodium urate crystals, NLRP3 inflammasome, IL-1β, interleukin-6, MCP-1, neutrophil infiltration, peritonitis, potassium oxonate, renal protection, anti-inflammatory activity, caspase-1
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Anti-Inflammatory Agents, omega-Chloroacetophenone, Inflammation, Male, Mice, Inbred ICR, Neutrophils, Peritonitis, Triterpenes, Uric Acid, Arthritis, Gouty, Cytokines, Neutrophil Infiltration, Hyperuricemia
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