Cited by 30Gout, Hyperuricemia, Uric AcidInflammasome and immune disordersNatural Compounds in Disease Treatment

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Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition

Lu, Xiaohui, Zeng, Runming, Lin, Jing, Hu, Jun, Rong, Zhijie, Xu, Weicai, Liu, Zewa, Zeng, Wanting·2019·Immunopharmacology and Immunotoxicology

DOI 10.1080/08923973.2019.1590721

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Abstract

Objectives: Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints, which is associated with the rise of serum urate content. This study aims to investigate the therapeutic effect of Madecassoside on gouty arthritis and hyperuricemia. Methods: DBA/1 mice were intradermally injected with MSU to stimulate joint inflammation or intraperitoneally injected with MSU to trigger peritonitis. Moreover, ICR mice were exposed to potassium oxonate to stimulate hyperuricemia. Results: Madecassoside repressed MSU-triggered pad swelling, joint 99mTc uptake, and joint inflammation in DBA/1 mice with gouty arthritis. Neutrophil infiltration and IL-1β & IL-6 & MCP-1 secretion was also alleviated in lavage fluids from DBA/1 mice with peritonitis due to Madecassoside treatment. Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation. In hyperuricemic mice, Madecassoside improved renal dysfunction. Serum uric acid, BUN, and creatinine were down-regulated by Madecassoside. Conclusion: These findings indicate that Madecassoside has potential to ameliorate inflammation in both acute gouty arthritis model and peritonitis model, probably via regulating IL-1β and NLRP3 expression. Practical point: Madecassoside also exhibited a urate-lowering effect and a renal protective effect in hyperuricemic mice.

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Authors: Lu, X., Zeng, R., Lin, J., Hu, J., Rong, Z., Xu, W., Liu, Z., & Zeng, W.
Affiliations: First Affiliated Hospital of Shantou University Medical College (CN)
Department of Orthopedic Surgery, The First Affiliate Hospital of Shantou University Medical College
University College London (GB)
Corresponding author: Lu, Xiaohui
ORCID: Lin, Jing
Hu, Jun
Zeng, Wanting
Venue: Immunopharmacology and Immunotoxicology
Publisher: Informa UK Limited
Published: 2019-03-04
Volume: 41
Issue: 2
Pages: 277-284
ISSN: 0892-3973 (ISSN-L)
1532-2513
DOI: 10.1080/08923973.2019.1590721
OpenAlex: W2945752146
Cited by: 30
References: 45
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 1
FWCI: 2.31
Type: journal article
Language: en
Open access: closed
Licence: doi.org/10.1080/policies-text-data-mining (tdm)
Locations: Immunopharmacology and Immunotoxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: madecassoside, gout, hyperuricemia, monosodium urate crystals, NLRP3 inflammasome, IL-1β, interleukin-6, MCP-1, neutrophil infiltration, peritonitis, potassium oxonate, renal protection, anti-inflammatory activity, caspase-1
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Anti-Inflammatory Agents, omega-Chloroacetophenone, Inflammation, Male, Mice, Inbred ICR, Neutrophils, Peritonitis, Triterpenes, Uric Acid, Arthritis, Gouty, Cytokines, Neutrophil Infiltration, Hyperuricemia

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Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition

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