The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Experimental Exposure to Wood-Smoke Particles in Healthy Humans: Effects on Markers of Inflammation, Coagulation, and Lipid Peroxidation
Abstract
Particulate air pollution is known to increase cardiovascular morbidity and mortality. Proposed mechanisms underlying this increase include effects on inflammation, coagulation factors, and oxidative stress, which could increase the risk of coronary events and atherosclerosis. The aim of this study was to examine whether short-term exposure to wood smoke affects markers of inflammation, blood hemostasis, and lipid peroxidation in healthy humans. Thirteen subjects were exposed to wood smoke and clean air in a chamber during two 4-h sessions, 1 wk apart. The mass concentrations of fine particles at wood smoke exposure were 240-280 mug/m3, and number concentrations were 95,000-180,000/cm3. About half of the particles were ultrafine (< 100 nm). Blood and urine samples were taken before and after the experiment. Exposure to wood smoke increased the levels of serum amyloid A, a cardiovascular risk factor, as well as factor VIII in plasma and the factor VIII/von Willebrand factor ratio, indicating a slight effect on the balance of coagulation factors. Moreover, there was an increased urinary excretion of free 8-iso-prostaglandin2alpha, a major F2-isoprostane, though this was based on nine subjects only, indicating a temporary increase in free radical-mediated lipid peroxidation. Thus, wood-smoke particles at levels that can be found in smoky indoor environments seem to affect inflammation, coagulation, and possibly lipid peroxidation. These factors may be involved in the mechanisms whereby particulate air pollution affects cardiovascular morbidity and mortality. The exposure setup could be used to establish which particle characteristics are critical for the effects.
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Cites
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J. (2004) · Circulation · doi:10.1161/01.cir.0000108927.80044.7f · Cited by 2,592
Passage of inhaled particles into the blood circulation in humans
Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., & Nemery, B. (2002) · Circulation · doi:10.1161/hc0402.104118 · Cited by 1,719
Increased plasma viscosity during an air pollution episode: a link to mortality?
Peters, A., Döring, A., Wichmann, H.-E., & Koenig, W. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01211-7 · Cited by 706
Changes of Plasma Coagulation and Fibrinolysis in Response to Mental Stress
Jern, C., Eriksson, E., Tengborn, L., Risberg, B., Wadenvik, H., & Jern, S. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646899 · Cited by 206
Liao, D., Heiss, G., Chinchilli, V. M., Duan, Y., Folsom, A. R., Lin, H.-M., & Salomaa, V. (2005) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/sj.jea.7500408 · Cited by 129 · cited 2×
“Factor VIII could be considered as a marker both of inflammation and of hemostasis (Liao et al., 2005).”
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Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Woodsmoke Health Effects: A Review
Naeher, L. P., Brauer, M., Lipsett, M., Zelikoff, J. T., Simpson, C. D., Koenig, J. Q., & Smith, K. R. (2007) · Inhalation Toxicology · doi:10.1080/08958370600985875 · Cited by 1,530
Estimated Global Mortality Attributable to Smoke from Landscape Fires
Johnston, F. H., Henderson, S. B., Chen, Y., Randerson, J. T., Marlier, M., DeFries, R. S., Kinney, P., Bowman, D. M. J. S., & Brauer, M. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104422 · Cited by 852
Nanotechnology Safety Concerns Revisited
Stern, S. T., & McNeil, S. E. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfm169 · Cited by 560
Oxidative stress pathways of air pollution mediated toxicity: Recent insights
Gangwar, R. S., Bevan, G. H., Palanivel, R., Das, L., & Rajagopalan, S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101545 · Cited by 409
Metadata
- Authors
- Barregard, L., Sällsten, G., Gustafson, P., Andersson, L., Johansson, L., Basu, S., & Stigendal, L.
- Venue
- Inhalation Toxicology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 18
- Issue
- 11
- Pages
- 845-853
- ISSN
- 0895-8378 (ISSN-L)
- 1091-7691
- OpenAlex
- W2121659530
- Cited by
- 274
- References
- 8
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barregard, L., Sällsten, G., Gustafson, P., Andersson, L., Johansson, L., Basu, S., & Stigendal, L. (2006). Experimental Exposure to Wood-Smoke Particles in Healthy Humans: Effects on Markers of Inflammation, Coagulation, and Lipid Peroxidation. Inhalation Toxicology. https://doi.org/10.1080/08958370600685798
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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