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Cited by 129Air Quality and Health ImpactsIndoor Air Quality and Microbial ExposureEnvironmental Justice and Health Disparities

Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study

Liao, Duanping, Heiss, Gerardo, Chinchilli, Vernon M, Duan, Yinkang, Folsom, Aaron R, Lin, Hung-Mo, Salomaa, Veikko·2005·Journal of Exposure Science & Environmental Epidemiology
DOI 10.1038/sj.jea.7500408
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Abstract

To elucidate the health effects of air pollution, the short-term association of criteria pollutants (particles <10 microm in diameter [PM(10)], O(3), CO, NO(2), and SO(2)) with hemostatic and inflammatory markers were examined using a population-based sample of 10,208 middle-age males and females of the biracial cohort of Atherosclerosis Risk in Communities (ARIC) study. For each participant, we calculated the following pollutant exposures 1-3 days prior to the randomly allocated cohort examination date: PM(10), CO, NO(2), and SO(2) as 24-h averages, and O(3) as an 8-h average of the hourly measures. The hemostatic/inflammatory factors included fibrinogen, factor VIII-C, von Willebrand factor (vWF), albumin, and white blood cell count (WBC). Linear regression models were used to adjust for cardiovascular disease (CVD) risk factors, demographic and socioeconomic variables, and relevant meteorological variables. One standard deviation (SD) increment of PM(10) (12.8 microg/m(3)) was significantly (P < 0.05) associated with 3.93% higher of vWF among diabetics and 0.006 g/dl lower of serum albumin among persons with a history of CVD. One SD increment of CO (0.60 p.p.m.) was significantly (P < 0.01) associated with 0.018 g/dl lower of serum albumin. Significant curvilinear associations, indicative of threshold effects, for PM(10) with factor VIII-C, O(3) with fibrinogen and vWF, and SO(2) with factor VIII-C, WBC, and serum albumin were found. This population-based study suggest that the hemostasis/inmflammation markers analyzed, which are linked to higher risk of CHD, are associated adversely with environmentally relevant ambient pollutants, with the strongest associations in the upper range of the pollutant distributions, and in persons with a positive history of diabetes and CHD.

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  • Increased exposure to ambient ozone has been associated with increased levels of hemostatic markers, including fibrinogen, von Willebrand factor, and plasminogen activator inhibitor-1.

    “Increased exposure to ambient ozone has been associated with increased levels of hemostatic markers, including fibrinogen (48–50), von Willebrand factor (49), and plasminogen activator inhibitor-1 (48).”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [49]

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Authors
Liao, D., Heiss, G., Chinchilli, V. M., Duan, Y., Folsom, A. R., Lin, H.-M., & Salomaa, V.
Affiliations
  • Pennsylvania State University (US)
  • University of North Carolina at Chapel Hill (US)
  • University of Minnesota (US)
  • Finnish Institute for Health and Welfare (FI)
Corresponding author
Liao, Duanping
ORCID
Venue
Journal of Exposure Science & Environmental Epidemiology
Publisher
Springer Science and Business Media LLC
Published
2004-11-10
Volume
15
Issue
4
Pages
319-328
ISSN
  • 1559-0631 (ISSN-L)
  • 1559-064X
DOI
10.1038/sj.jea.7500408
OpenAlex
W1999733163
Cited by
129
References
55
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 2 · 2017: 11 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 6
FWCI
5.75
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Exposure Science & Environmental Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01es010189-03)
  • National Institute of Environmental Health Sciences (1-R01-ES10189-01)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
Keywords
air pollution, criteria pollutants, PM10, ozone, carbon monoxide, nitrogen dioxide, sulfur dioxide, hemostatic markers, inflammatory markers, von Willebrand factor, fibrinogen, factor VIII, serum albumin, white blood cell count, diabetes mellitus, coronary artery disease, threshold effects, Atherosclerosis Risk in Communities Study
MeSH terms
Air Pollutants, Carbon Monoxide, Cardiovascular Diseases, Dust, Environmental Monitoring, Factor VIII, Female, Fibrinogen, Hemostasis, Humans, Inflammation, Leukocyte Count, Male, Middle Aged, Nitrogen Dioxide, Ozone, Regression Analysis, Sulfur Dioxide, von Willebrand Factor

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