Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes
Abstract
extract-loaded niosomes (CAE-Nio) and surface modified niosomes by hyaluronic acid (CAE-Nio-HA) to enhance transdermal penetration. Niosome formulations were prepared by film hydration method using Tween 60 and Span 60 as nonionic surfactants, cholesterol and various CAE contents. Various HA concentrations were investigated to obtain optimized CAE-Nio enhancing further skin penetration. Results showed that niosomes prepared from Tween 60 yielded suitable CAE encapsulated niosomes with mean particle size and zeta-potential of 155 nm and -15 mV, respectively. The niosomes exhibited high encapsulation efficiency (%EE) and drug loading capacity (%DL) of 71-77% and 3-7%, respectively. Incorporating HA to niosome decreased %DL and caused larger particle size and increased zeta-potential in a dose dependent manner while %EE remained unaffected. The sustained-release behaviour of CAE from all niosomes was under a diffusion controlled mechanism. Asiaticoside, a relatively polar compound from CAE-Nio-HA could penetrate through the stratum corneum and dermis in a larger amount than from CAE-Nio and CAE solution. CAE-Nio-HA formulations showed good stability under low temperature (4 °C and 25 °C) for periods longer than 4 months. In conclusion, the developed Nio-HA is a promising delivery system for asiaticoside to enhanced dermal absorption, permeation and accumulation in viable epidermis and dermis layers. This system can also be applied to other hydrophilic natural active compounds.
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Niosome formulations incorporating asiaticoside showed improved stability, sustained release, and deep epidermal delivery.
“Formulations incorporating asiaticoside showed improved stability, sustained release, and deep epidermal delivery (Hnin et al. 2024; Wichayapreechar et al. 2020).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Wichayapreechar et al. 2020
Niosomes surface-modified with hyaluronic acid have been optimized for enhanced skin deposition.
“Niosomes, formed from nonionic surfactants and often surface-modified with hyaluronic acid, have been optimized for enhanced skin deposition.”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Wichayapreechar et al. 2020
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- Authors
- Wichayapreechar, P., Anuchapreeda, S., Phongpradist, R., Rungseevijitprapa, W., & Ampasavate, C.
- Affiliations
- Chiang Mai University (TH)
- Ratchathani University (TH)
- Corresponding author
- Rungseevijitprapa, Wandee
- Ampasavate, Chadarat
- Venue
- Journal of Liposome Research
- Publisher
- Informa UK Limited
- Published
- 2019-05-27
- Volume
- 30
- Issue
- 2
- Pages
- 197-207
- ISSN
- 0898-2104 (ISSN-L)
- 1532-2394
- OpenAlex
- W2943871578
- Cited by
- 43
- References
- 49
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Liposome Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research and Researchers for Industries (RRi) grant under the Office of the Prime Minister, Royal Thai Government and Bangkok Lab & Cosmetic Co., Ltd (PHD5810039)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- Centella asiatica extract, hyaluronic acid, niosomes, dermal drug delivery, transdermal permeation, asiaticoside, surface modification, Tween 60, Span 60, encapsulation efficiency, sustained drug release, stratum corneum, epidermis, formulation stability
- MeSH terms
- Animals, Hyaluronic Acid, Lipid Bilayers, Liposomes, Particle Size, Plant Extracts, Skin, Surface Properties, Swine, Triterpenes, Centella
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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