Effect of 12-month treatment with metformin and/or oral contraceptives on health-related quality of life in polycystic ovary syndrome
Abstract
Health-related quality of life (HRQoL) is impaired in polycystic ovary syndrome (PCOS), but the effect of treatment with metformin (M) and/or oral contraceptives (OCP) is undetermined. To assess changes in HRQoL during 12-month randomized treatment with M, OCP or M + OCP in PCOS. Ninety women with PCOS were randomized to treatment with M, OCP or M + OCP. HRQoL was evaluated by a PCOS-specific visual analog scale (PCOS-VAS) regarding 1: Facial hair, 2: Body hair, 3: Acne, 4: Irregular menses, 5: Weight and 6: PCOS in general, and Short Form 36 (SF-36). PCOS-VAS1(facial hair) improved during treatment with OCP (n = 23) compared to M (n = 19), and during M + OCP (n = 23) compared to M treatment, whereas changes in PCOS-VAS2-6 and SF-36 scores were comparable between the three medical intervention groups. Pooled data (n = 65) showed improved PCOS-VAS scores during treatment (all p < .05), but changes in PCOS-VAS were unassociated with changes in BMI or FG-scores despite significant weight-loss during treatment with M (-3.0 kg (-10.3; 0.6)) and M + OCP (-1.9 kg (-4.9; 0.1)) and decreased FG-score during M + OCP treatment (median (quartiles)). PCOS-VAS scores improved significantly and to the same extent during treatment with M, OCP or M + OCP.
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In women with PCOS, there is no difference in health-related quality of life between the compared treatments.
“Results from 3 identified studies (32, 42, 50) showed conflicting results and our overall assessment is that there is no difference in quality of life.”
From Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis (2024) · cites this paper as [32]
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- Authors
- Altinok, M. L., Ravn, P., Andersen, M., & Glintborg, D.
- Affiliations
- Odense University Hospital (DK)
- Corresponding author
- Altinok, Magda Lambaa
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2018-04-16
- Volume
- 34
- Issue
- 10
- Pages
- 859-863
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2802047677
- Cited by
- 28
- References
- 31
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- the Jacob Madsen’s and Olga Madsen’s Foundation
- the Institute of Clinical research
- Odense University Hospital
- Kolding Hospital
- A.P. Møller’s Foundation
- Bernard and Marie Klein’s Foundation
- the Novo Nordisk Foundation
- the Danish Medical Association
- Sandoz
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, metformin, oral contraceptives, health-related quality of life, facial hair, body hair, acne, menstrual irregularity, weight loss, insulin resistance, SF-36
- MeSH terms
- Adolescent, Adult, Contraceptives, Oral, Hormonal, Female, Humans, Hypoglycemic Agents, Metformin, Polycystic Ovary Syndrome, Quality of Life, Treatment Outcome, Young Adult
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