Improvement in quality-of-life questionnaire measures in obese adolescent females with polycystic ovary syndrome treated with lifestyle changes and oral contraceptives, with or without metformin
Open accessAbstract
We studied the effect of metformin or placebo in a lifestyle modification program combined with oral contraceptives (OC) on quality-of-life parameters measured by the polycystic ovary syndrome (PCOS) questionnaire in obese adolescent women with validated PCOS. The quality-of-life indicators were measured at baseline and conclusion for five domains on the PCOS questionnaire, with equal improvement in scores in both placebo and metformin groups, suggesting that the addition of metformin does not add improvement to quality-of-life measures above those observed with lifestyle modification and OC treatment.
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Lifestyle interventions in adolescents with PCOS have shown additional improvements in quality of life.
“Lifestyle interventions in adolescents with PCOS have shown additional improvements in quality of life [160, 164, 165].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [165]
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- Authors
- Harris-Glocker, M., Davidson, K., Kochman, L., Guzick, D., & Hoeger, K.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 93
- Issue
- 3
- Pages
- 1016-1019
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3756311
- OpenAlex
- W2035075638
- Cited by
- 66
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Rochester
- National Institutes of Health (5k23hd043881-02)
- National Center for Research Resources (UL1RR024160)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23 HD043881-01A1, K23 HD043881)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, adolescent obesity, quality of life, metformin, oral contraceptives, lifestyle modification, placebo comparison
- MeSH terms
- Adolescent, Combined Modality Therapy, Contraceptives, Oral, Female, Humans, Hypoglycemic Agents, Life Style, Metformin, Obesity, Patient Education as Topic, Polycystic Ovary Syndrome, Prospective Studies, Quality of Life, Surveys and Questionnaires
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