Medical Treatment and Comorbidity in Polycystic Ovary Syndrome: An Updated Review
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Abstract Polycystic ovary syndrome (PCOS) is defined by hyperandrogenism, irregular menses, and polycystic ovaries when other etiologies are excluded. The risk of type 2 diabetes and cardiovascular disease is increased in PCOS. Furthermore, the immune function in PCOS is impaired with elevated circulating of autoantibodies and increased risk of thyroid disease. Especially obese women with PCOS are at increased risk of nonalcoholic fatty liver disease. Medical treatment of PCOS involves antiandrogen treatment in combination with insulin sensitizing drugs. Oral contraceptives are often applied as antiandrogens, but spironolactone could have additional vascular benefits. New and upcoming treatments for PCOS involve GLP-1 agonists, DPP4 inhibitors, SGLT2 inhibitors, myoinositol, thyroid hormones, and vitamin supplements. Statins are rarely indicated for treatment of dyslipidemia in PCOS, but statins could improve PCOS phenotype. Use of antidepressants in PCOS could have adverse effects on PCOS metabolic phenotype. In the present article, we give an update regarding established and upcoming medical treatment for PCOS and for comorbidities of PCOS.
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Bednarz, K., Kowalczyk, K., Cwynar, M., Czapla, D., Czarkowski, W., Kmita, D., Nowak, A., & Madej, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084334 · Cited by 148 · see citing works
- Authors
- Glintborg, D., & Andersen, M.
- Affiliations
- Odense University Hospital (DK)
- Corresponding author
- Glintborg, Dorte
- Venue
- Current Opinion in Endocrine and Metabolic Research
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 12
- Pages
- 33-40
- ISSN
- 2451-9650 (ISSN-L)
- OpenAlex
- W3011692608
- Semantic Scholar
- c4ce0623b368632d1c5ed904ad9e3de57dc24fbd
- Cited by
- 20
- References
- 82
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Current Opinion in Endocrine and Metabolic Research (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, hyperandrogenism, antiandrogen therapy, insulin-sensitizing drugs, oral contraceptives, spironolactone, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT2 inhibitors, myo-inositol, thyroid hormones, vitamin supplements, statins, dyslipidemia, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, obesity, autoantibodies, thyroid dysfunction, antidepressants, comorbidities
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