Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review
Open accessAbstract
Increasing evidence supports the contribution of vitamin D deficiency (VDD) in metabolic disturbances among women with polycystic ovary syndrome (PCOS). This review aims to assess the associations between vitamin D levels and metabolic/endocrine dysregulations and to determine the effects of vitamin D supplementation on glucose metabolism, insulin sensitivity, lipid profile, and hormones functionality in PCOS patients. We searched in PubMed human randomized controlled trials (RCTs) published in English between 2016 and 2019 on the effects of vitamin D supplementation on PCOS. Nine studies were included and analyzed. Vitamin D supplementation restored physiological serum 25(OH)D levels in PCOS women in all the studies included. In six studies, it significantly decreased fasting plasma glucose and brought to improvements in insulin resistance (IR) and serum fasting insulin. In addition, four studies reported decreases of serum triglycerides, while discordant data are reported as far as LDL, HDL, and total cholesterol levels. High-doses of vitamin D (4000 IU), compared with low-dose (1000 IU), and placebo, showed beneficial effects on total testosterone, sex hormone-binding globulin (SHBG) and free androgen index (FAI). Vitamin D supplementation at high doses for a period of at least 12 weeks, may lead to improvement in terms of glucose level, insulin sensitivity, hyperlipidemia, and hormonal functionality in PCOS women.
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- Authors
- Menichini, D., & Facchinetti, F.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Menichini, Daniela
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2019-06-12
- Volume
- 36
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2951932951
- Cited by
- 73
- References
- 29
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 13 · 2020: 8 · 2019: 2
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- vitamin D supplementation, polycystic ovary syndrome, vitamin D deficiency, insulin resistance, glucose metabolism, lipid profile, hypertriglyceridemia, testosterone, sex hormone-binding globulin, free androgen index, 25-hydroxyvitamin D, high-dose vitamin D
- MeSH terms
- Blood Glucose, Female, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, Cholesterol, LDL, Polycystic Ovary Syndrome, Sex Hormone-Binding Globulin, Testosterone, Triglycerides, Vitamin D, Vitamin D Deficiency, Vitamins, Treatment Outcome, Dietary Supplements
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