The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The platelet release reaction: granules' constituents, secretion and functions
Abstract
Although anucleated, blood platelets are highly organized cells rich in different types of organelles. Three specific granule populations store different types of constituents, some of which are at high concentrations. Platelets thus transport some specific compounds through the whole body. During circulation, platelets are reactive to various stimuli and release the materials stored in the specific granules. This 'release reaction' is an important step of primary haemostasis. Energy and messengers required for platelet reactivity are provided by mitochondria and the dense tubular system. Each granule population has specific properties concerning both the structure and the role played by the released constituents. Dense granules contain small non-protein molecules that are secreted to recruit other platelets. alpha-Granules contain large adhesive and healing proteins. Lysosomes contain hydrolases able to eliminate the circulating platelet aggregate. The extrusion of storage granules' content to the platelet's environment occurs according to regulated secretion events: movements of granules, apposition and fusion of granule and plasma membranes. Typical platelet disorders resulting from a storage granule abnormality are referred to as a storage pool defect and are characterized by a prolonged bleeding time.
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Cites
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Cited by
Autologous platelets as a source of proteins for healing and tissue regeneration
Anitua, E., Andia, I., Ardanza, B., Nurden, P., & Nurden, A. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0440 · Cited by 1,495
Platelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
The ectonucleotidases CD 39 and CD 73: Novel checkpoint inhibitor targets
Allard, B., Longhi, M. S., Robson, S. C., & Stagg, J. (2017) · Immunological Reviews · doi:10.1111/imr.12528 · Cited by 927
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
Fujimura, H., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J.-I., Sun, B., Altar, C., & Tandon, N. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613072 · Cited by 777
Karege, F., Bondolfi, G., Gervasoni, N., Schwald, M., Aubry, J.-M., & Bertschy, G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.008 · Cited by 593
Metadata
- Authors
- Rendu, F., & Brohard-Bohn, B.
- Venue
- Platelets
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 12
- Issue
- 5
- Pages
- 261-273
- ISSN
- 0953-7104 (ISSN-L)
- 1369-1635
- OpenAlex
- W2032600755
- Cited by
- 599
- References
- 46
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
