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Cited by 411

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

Open access
Taraboletti, G, Roberts, D, Liotta, L A, Giavazzi, R·1990·The Journal of cell biology
DOI 10.1083/jcb.111.2.765
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Abstract

Components of the extracellular matrix have been shown to modulate the interaction of endothelial cells with their microenvironment. Here we report that thrombospondin (TSP), an extracellular matrix component, induces adhesion and spreading of murine lung capillary (LE-II) and bovine aortic (BAEC) endothelial cells. This TSP-induced spreading was inhibited by heparin and fucoidan, known to bind the amino-terminal globular domain of the molecule. In addition, endothelial cells were induced to migrate by a gradient of soluble TSP (chemotaxis). The chemotactic response was inhibited by heparin and fucoidan, as well as by the mAb A2.5, which also binds to the amino-terminal domain. These data are in agreement with our previous observation that the TSP aminoterminal heparin binding region is responsible for the induction of tumor cell spreading and chemotactic motility. The inhibition of chemotaxis and spreading by antibodies against the beta 3 but not the beta 1 chain of the integrin receptor points to a role for the integrins in the interaction of endothelial cells with TSP. We also found that TSP modulates endothelial cell growth. When added to quiescent LE-II cells, it inhibited the mitogenic effects of serum and the angiogenic factor bFGF, in a dose-dependent manner. The inhibition of DNA synthesis detected in the mitogenic assay resulted in a true inhibition of BAEC and LE-II cell growth, as assessed by proliferation assay. This work indicates that TSP affects endothelial cell adhesion, spreading, motility and growth. TSP, therefore, has the potential to modulate the angiogenic process.

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Metadata

Authors
Taraboletti, G., Roberts, D., Liotta, L. A., & Giavazzi, R.
Venue
The Journal of cell biology
Publisher
Rockefeller University Press
Published
1990-08-01
Volume
111
Issue
2
Pages
765-772
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.111.2.765
OpenAlex
W2154086195
Cited by
411
References
37
FWCI
5.19
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. https://app.cochat.ai/papers/10.1083/jcb.111.2.765
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Taraboletti, G., Roberts, D., Liotta, L. A., & Giavazzi, R. (1990). Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. The Journal of cell biology. https://doi.org/10.1083/jcb.111.2.765

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.