Cited by 262Multiple Sclerosis Research StudiesTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Depression in multiple sclerosis

Patten, Scott B., Marrie, Ruth Ann, Carta, Mauro G.·2017·International Review of Psychiatry

DOI 10.1080/09540261.2017.1322555

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Abstract

Depressive disorders occur in up to 50% of people living with multiple sclerosis (MS). Prevalence estimates are generally 2-3-times higher than those of the general population. Myriad aetiologic factors may contribute to the aetiology of depression in MS including biological mechanisms (e.g. hippocampal microglial activation, lesion burden, regional atrophy), as well as the stressors, threats, and losses that accompany living with an unpredictable and often disabling disease. Some prominent risk factors for depression such as (younger) age, (female) sex, and family history of depression are less consistently associated with depression in MS than they are in the general population. Management of depression in MS has not been well studied, but available data on detection and treatment align with general principles of depression management. While the validity of standard measurement scales has often been questioned, available evidence suggests that standard scales provide valid ratings. Evidence for the effectiveness of depression treatments in MS is limited, but available evidence supports the effectiveness of standard treatment approaches, including both cognitive behavioural therapies and antidepressant medications.

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Authors: Patten, S. B., Marrie, R. A., & Carta, M. G.
Affiliations: University of Calgary (CA)
University of Manitoba (CA)
University of Cagliari (IT)
Corresponding author: Patten, Scott B.
ORCID: Patten, Scott B.
Marrie, Ruth Ann
Carta, Mauro G.
Venue: International Review of Psychiatry
Publisher: Informa UK Limited
Published: 2017-07-06
Volume: 29
Issue: 5
Pages: 463-472
ISSN: 0954-0261 (ISSN-L)
1369-1627
DOI: 10.1080/09540261.2017.1322555
OpenAlex: W2726625509
Cited by: 262
References: 103
Citations by year: 2026: 16 · 2025: 22 · 2024: 34 · 2023: 33 · 2022: 43 · 2021: 34 · 2020: 57 · 2019: 11 · 2018: 7 · 2017: 2
FWCI: 3.36
Type: journal article
Language: en
Open access: closed
Locations: International Review of Psychiatry (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, public-domain)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: depression, multiple sclerosis, prevalence, etiology, lesion burden, brain atrophy, stressors, risk factors, depression screening, depression treatment, cognitive behavioral therapy, antidepressants, measurement scales
MeSH terms: Adult, Antidepressive Agents, Depression, Female, Humans, Male, Multiple Sclerosis, Brief Psychiatric Rating Scale, Cognitive Behavioral Therapy, Prevalence

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