The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Depression in multiple sclerosis
Abstract
Depressive disorders occur in up to 50% of people living with multiple sclerosis (MS). Prevalence estimates are generally 2-3-times higher than those of the general population. Myriad aetiologic factors may contribute to the aetiology of depression in MS including biological mechanisms (e.g. hippocampal microglial activation, lesion burden, regional atrophy), as well as the stressors, threats, and losses that accompany living with an unpredictable and often disabling disease. Some prominent risk factors for depression such as (younger) age, (female) sex, and family history of depression are less consistently associated with depression in MS than they are in the general population. Management of depression in MS has not been well studied, but available data on detection and treatment align with general principles of depression management. While the validity of standard measurement scales has often been questioned, available evidence suggests that standard scales provide valid ratings. Evidence for the effectiveness of depression treatments in MS is limited, but available evidence supports the effectiveness of standard treatment approaches, including both cognitive behavioural therapies and antidepressant medications.
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“patients with autoimmune diseases with elevated TH17 cells often exhibit comorbid depression (Kurd et al., 2010; Patten et al., 2017).”
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Boczkowska, M. A. (2024) · Roczniki Pedagogiczne · doi:10.18290/rped24161.5
Campese, S., Lyons, J. N., Learmonth, Y. C., Metse, A. P., Kermode, A. G., Marck, C. H., & Karahalios, A. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105763
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Chapter 22. Neurocognitive Disorders
Merideth, F. L., Vahia, I. V., & Jeste, D. V. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg22
Chapter 2. The Neurological Examination for Neuropsychiatric Assessment
Benjamin, S., & Lauterbach, M. D. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg02
Chapter 25. Somatic Symptom and Related Disorders
Dickerman, A. L., & Muskin, P. R. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg25
Chapter 1. An Internist’s Approach to the Neuropsychiatric Patient
Rencic, J. J., & Salem, D. N. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg01
Chapter 4. Neuroimaging, Electroencephalography, and Lumbar Puncture in Medical Psychiatry
Talmasov, D., & Klein, J. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg04
Chapter 6. Cardiovascular Disease
Shapiro, P. A. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg06
Chapter 7. Endocrine Disorders and Their Psychiatric Manifestations
Gagliardi, J. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg07
Doghramji, K. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg24
McCarron, R. M., Sheth, S. J., Mesa, C. D., & Parish, M. B. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg23
Chapter 3. The Bedside Cognitive Examination in Medical Psychiatry
Glass, S. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg03
Chapter 17. Psychotic Disorders Due to Medical Illnesses
Brown, H. E., Mukerji, S., & Freudenreich, O. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg17
Chapter 10. Gastroenterological Disease in Patients With Psychiatric Disorders
Nadkarni, A., & Silbersweig, D. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg10
(2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.index
Chapter 16. Neurodevelopmental Disorders
Hauptman, A. J., & Benjamin, S. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg16
Chapter 18. Catatonia in the Medically Ill Patient
Beach, S. R., & Fricchione, G. L. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg18
Chapter 12. Neurological Conditions and Their Psychiatric Manifestations
Fogel, B. S., Baslet, G. C., Safar, L. T., Raynor, G., & Silbersweig, D. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg12
Chapter 20. Anxiety and Related Disorders: Manifestations in the General Medical Setting
Hebert, C. L., Banayan, D. J., Forcén, F. E., Perticone, K., Guttikonda, S., & Pollack, M. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg20
Chapter 13. Cancer: Psychiatric Care of the Oncology Patient
Fernandez-Robles, C. G., & Glass, S. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg13
Chapter 19. Mood Disorders Due to Medical Illnesses
Mauer, S., Querques, J., & D, P. S. M. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg19
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Chapter 15. Women’s Mental Health and Reproductive Psychiatry
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Chapter 8. Inflammatory Diseases and Their Psychiatric Manifestations
Gonzalez, R. L., & Nemeroff, C. B. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg08
Chapter 14. Dermatology: Psychiatric Considerations in the Medical Setting
Taylor, K. A., Gordon-Elliott, J. S., & Muskin, P. R. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg14
Chapter 9. Infectious Diseases and Their Psychiatric Manifestations
Freudenreich, O., Donnelly-Boylen, K. M., & Gandhi, R. T. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg09
Chapter 21. Substance Use Disorders in the Medical Setting
Sharma, S., Haddad, S. E., & Suzuki, J. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg21
Chapter 5. Toxicological Exposures and Nutritional Deficiencies in the Psychiatric Patient
Zein, M., Khan, S., Legha, J. K., & Wasserman, L. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg05
Chapter 11. Renal Disease in Patients With Psychiatric Illness
Chan, L., & Bostwick, J. M. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg11
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Metadata
- Authors
- Patten, S. B., Marrie, R. A., & Carta, M. G.
- Affiliations
- University of Calgary (CA)
- University of Manitoba (CA)
- University of Cagliari (IT)
- Corresponding author
- Patten, Scott B.
- Venue
- International Review of Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2017-07-06
- Volume
- 29
- Issue
- 5
- Pages
- 463-472
- ISSN
- 0954-0261 (ISSN-L)
- 1369-1627
- OpenAlex
- W2726625509
- Cited by
- 262
- References
- 103
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 34 · 2023: 33 · 2022: 43 · 2021: 34 · 2020: 57 · 2019: 11 · 2018: 7 · 2017: 2
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Review of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, public-domain)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, multiple sclerosis, prevalence, etiology, lesion burden, brain atrophy, stressors, risk factors, depression screening, depression treatment, cognitive behavioral therapy, antidepressants, measurement scales
- MeSH terms
- Adult, Antidepressive Agents, Depression, Female, Humans, Male, Multiple Sclerosis, Brief Psychiatric Rating Scale, Cognitive Behavioral Therapy, Prevalence
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