The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Rapid Translocation Frequency Analysis in Humans Decades after Exposure to Ionizing Radiation
Abstract
This paper presents an analysis of the utility of fluorescence in situ hybridization (FISH) with whole-chromosome probes for measurement of the genomic frequency of translocations found in the peripheral blood of individuals exposed to ionizing radiation. First, we derive the equation: Fp = 2.05fp(1-fp)FG, relating the translocation frequency, Fp, measured using FISH to the genomic translocation frequency, FG, where fp is the fraction of the genome covered by the composite probe. We demonstrate the validity of this equation by showing that: (a) translocation detection efficiency predicted by the equation is consistent with experimental data as fp is changed; (b) translocation frequency dose-response curves measured in vitro using FISH agree well with dicentric frequency dose-response curves measured in vitro using conventional cytogenetic procedures; and (c) the genomic translocation frequencies estimated from FISH measurements for 20 Hiroshima A-bomb survivors and four workers exposed to ionizing radiation during the Y-12 criticality accident are approximately the same as the translocation frequencies measured using G-banding. We also show that translocation frequency dose response curves estimated using FISH are similar for Hiroshima A-bomb survivors and for first division lymphocytes irradiated in vitro. We conclude with a discussion of the potential utility of translocation frequency analysis for assessment of the level of acute radiation exposure independent of the time between analysis and exposure.
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Cites
International Journal of Radiation Biology
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Self-citationRadiation-Induced Chromosome Damage in Man
Savage, J. R. K. (1984) · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine · doi:10.1080/09553008414551861 · Cited by 389
Current status of cytogenetic procedures to detect and quantify previous exposures to radiation
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Self-citationThe Relationship between Chromosome Aberrations and Low LET Radiation Dose to Human Lymphocytes
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Cited by
Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
Pfeiffer, P. (2000) · Mutagenesis · doi:10.1093/mutage/15.4.289 · Cited by 462
Ramsey, M. J., Moore, D. H., Briner, J. F., Lee, D. A., Olsen, L. A., Senft, J. R., & Tucker, J. D. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00015-x · Cited by 277
Chromosome aberration dosimetry in cosmonauts after single or multiple space flights
Durante, M., Snigiryova, G., Akaeva, E., Bogomazova, A., Druzhinin, S., Fedorenko, B., Greco, O., Novitskaya, N., Rubanovich, A., Shevchenko, V., et al. (2003) · Cytogenetic and Genome Research · doi:10.1159/000076288 · Cited by 146
Chromosome aberrations in the blood lymphocytes of astronauts after space flight
George, K., Durante, M., Wu, H., Willingham, V., Badhwar, G., & Cucinotta, F. A. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2 · Cited by 119
Chromosome aberrations of clonal origin are present in astronauts’ blood lymphocytes
George, K., Durante, M., Willingham, V., & Cucinotta, F. A. (2004) · Cytogenetic and Genome Research · doi:10.1159/000077498 · Cited by 26
Metadata
- Authors
- Lucas, J. N., Awa, A., Straume, T., Poggensee, M., Kodama, Y., Nakano, M., Ohtaki, K., Weier, H.-U., Pinkel, D., Gray, J., & Littlefield, G.
- Venue
- International Journal of Radiation Biology
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 62
- Issue
- 1
- Pages
- 53-63
- ISSN
- 0955-3002 (ISSN-L)
- 1362-3095
- OpenAlex
- W2108994753
- Cited by
- 434
- References
- 13
- FWCI
- 27.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lucas, J. N., Awa, A., Straume, T., Poggensee, M., Kodama, Y., Nakano, M., Ohtaki, K., Weier, H.-U., Pinkel, D., Gray, J., & Littlefield, G. (1992). Rapid Translocation Frequency Analysis in Humans Decades after Exposure to Ionizing Radiation. International Journal of Radiation Biology. https://doi.org/10.1080/09553009214551821
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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