Cited by 107Essential Oils and Antimicrobial ActivityMedicinal Plant ResearchInsect Pest Control Strategies

Suppression of tumor necrosis factor‐alpha‐induced neutrophil adherence responses by essential oils

Open access
Abe, Shigeru, Maruyama, Naho, Hayama, Kazumi, Ishibashi, Hiroko, Inoue, Shigeharu, Oshima, Haruyuki, Yamaguchi, Hideyo·2003·Mediators of Inflammation

Abstract

BACKGROUND: In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS: To assess their anti-inflammatory activities, effects of essential oils on neutrophil activation were examined in vitro. METHODS: Neutrophil activation was measured by tumor necrosis factor-alpha (TNF-alpha)-induced adherence reaction of human peripheral neutrophils. RESULTS: All essential oils tested at 0.1% concentration suppressed TNF-alpha-induced neutrophil adherence,and, in particular, lemongrass, geranium and spearmint oils clearly lowered the reaction even at 0.0125%. Similar inhibitory activities for the neutrophil adherence were obtained by their major constituent terpenoids: citral, geraniol, citronellol and carvone. In contrast, very popular essential oils, tea tree oil and lavender oil, did not display the inhibitory activity at the concentration. CONCLUSION: Thus, some essential oils used as antiinflammatory remedies suppress neutrophil activation by TNF-alpha at a low concentration (0.0125-0.025 %) in vitro.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1080/09629350310001633342

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lemongrass, geranium, and spearmint essential oils and their main components suppress TNF-α-induced neutrophil adherence responses without affecting TNF-α, by affecting neutrophil function.

    “Whether some essential oils are able to inhibit the production of pro-inflammatory cytokines such as TNF-α, some of them, particularly lemongrass, geranium and spearmint and their main components (citral, geraniol, citronellol, and carvone), can also suppress TNF-α-induced neutrophil adherence responses [120]. According to these authors, those essential oils or their major components do not affect”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Abe, S., Maruyama, N., Hayama, K., Ishibashi, H., Inoue, S., Oshima, H., & Yamaguchi, H.
Affiliations
Teikyo University (JP)
Corresponding author
Abe, Shigeru
Venue
Mediators of Inflammation
Publisher
Wiley
Published
2003-01
Volume
12
Issue
6
Pages
323-328
ISSN
  • 0962-9351 (ISSN-L)
  • 1466-1861
OpenAlex
W2130421481
Cited by
107
References
20
Citations by year
2026: 6 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 3
FWCI
3.81
Type
journal article
Language
en
Open access
Locations
  • Mediators of Inflammation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Kampo Medicine Research Fund
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Keywords
essential oils, anti-inflammatory activity, neutrophil activation, neutrophil adhesion, TNF-α, aromatherapy, lemongrass essential oil, geranium oil, spearmint oil, terpenoids, citral, geraniol, citronellol, carvone, tea tree oil, lavender essential oil
MeSH terms
Acyclic Monoterpenes, Cyclohexane Monoterpenes, Cell Adhesion, Cells, Cultured, Dose-Response Relationship, Drug, Humans, Lipopolysaccharides, Neutrophils, Oils, Volatile, Terpenes, Tetradecanoylphorbol Acetate, Tumor Necrosis Factor-alpha, Monoterpenes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review