Study on the Antiinflammatory Activity of Essential Oil from Leaves of Cinnamomum osmophloeum
Abstract
The leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) was investigated by gas chromatography-mass spectrometry, and 21 compounds were identified. The major constituents of leaf essential oil were the monoterpenes 1,8-cineole (17.0%) and santolina triene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyllene oxide (11.2%). In the antiinflammatory activity assay, we demonstrated that the essential oil has a higher capacity to inhibit proIL-1beta protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60 microg/mL, essential oil clearly inhibited proIL-1beta protein expression. Furthermore, a dose of 60 microg/mL of essential oil was effectively inhibitory for IL-1beta and IL-6 production but not for TNF-alpha, suggesting that essential oil was bioactive in antiinflammation in vitro. This study is the first to report antiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum.
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1,8-Cineole, santoline, spathulenol, and caryophyllene oxide, major constituents of Cinnamomum osmophloeum leaves essential oil, inhibit IL-1β and IL-6 production but not TNF-α.
“The ability to inhibit IL-1β and IL-6 production but not TNF-α was attributed to 1,8-cineole, santoline, spathulenol and caryophyllene oxide, major constituents of the essential oil of Cinnamomum osmophloeum Kaneh. leaves [109].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [109]
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- Authors
- Chao, L. K., Hua, K.-F., Hsu, H.-Y., Cheng, S.-S., Liu, J.-Y., & Chang, S.-T.
- Affiliations
- Chung Hwa University of Medical Technology (TW)
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-08-12
- Volume
- 53
- Issue
- 18
- Pages
- 7274-7278
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2009196668
- Cited by
- 221
- References
- 32
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 9 · 2021: 13 · 2020: 15 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 11 · 2013: 14 · 2012: 14
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Cinnamomum osmophloeum, leaf essential oil, anti-inflammatory activity, 1,8-cineole, spathulenol, caryophyllene oxide, monoterpenes, sesquiterpenes, IL-1β, interleukin-6, TNF-α, macrophages, lipopolysaccharide-induced inflammation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Lipopolysaccharides, Macrophages, Gas Chromatography-Mass Spectrometry, Oils, Volatile, Terpenes, Cytokines, Cell Death, Plant Leaves, Cinnamomum, Mice
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