Physical activity and cognitive function in adults with multiple sclerosis: an integrative review
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PURPOSE: To identify and synthesize the research evidence concerning (1) the relationship between physical activity and cognitive performance in persons with multiple sclerosis (MS) and (2) to review the reported effects of physical activity interventions on neurocognitive performance conducted in this population. METHODS: Relevant peer-reviewed journal articles were identified by searching PubMed, PsychINFO, and SPORTDiscus through May 2016. Full-text articles meeting the inclusion criteria were evaluated for quality using tools developed by the National Institutes of Health. Studies deemed to be of poor quality were excluded from the review. RESULTS: Nineteen studies meeting the inclusion/exclusion criteria were analyzed. Nine studies reported significant relationships between higher levels of physical activity or cardiorespiratory fitness and measures of cognitive function. Data extracted from 10 physical activity intervention studies reported mixed results on the effectiveness of physical activity to improve selected domains of cognitive function in persons with MS. CONCLUSION: Although correlational studies provide evidence to support a linkage between physical activity and cognitive function in persons with MS, this linkage is confounded by factors that may have influenced the studies' results. Evidence derived from intervention studies that could support a positive effect of physical activity on cognition in persons with MS is equivocal. Implications for Rehabilitation Physical activity has numerous benefits for persons with multiple sclerosis (MS) including improvements in balance, ambulation, depression, fatigue, and quality of life. Structured physical activity programs may contribute to cognitive function stability or improvement in persons with MS.
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There is Moderate evidence, largely from randomized controlled trials, that physical activity improves cognitive function in individuals with diseases or disorders that impair cognition, including ADHD, schizophrenia, multiple sclerosis, Parkinson's disease, and stroke.
“There is Moderate evidence, largely based on RCTs, indicating that PA improves cognitive function in individuals with diseases or disorders that impair cognitive function including ADHD (39), schizophrenia (58), multiple sclerosis (MS) (55), Parkinson’s disease (56), and stroke (53, 64).”
From Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines (2019) · cites this paper as [55]
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- Authors
- Morrison, J. D., & Mayer, L.
- Affiliations
- The University of Texas at Austin (US)
- Central Texas Neurology Consultants (US)
- Corresponding author
- Morrison, Janet D.
- Venue
- Disability and Rehabilitation
- Publisher
- Informa UK Limited
- Published
- 2016-10-20
- Volume
- 39
- Issue
- 19
- Pages
- 1909-1920
- ISSN
- 0963-8288 (ISSN-L)
- 1464-5165
- PMC
- PMC5554411
- OpenAlex
- W2538670878
- Cited by
- 38
- References
- 71
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Disability and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Nursing Research (F31NR014601)
- International Organization of MS Nurses (None)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Keywords
- multiple sclerosis, physical activity, cognitive function, neuropsychological performance, physical activity interventions, cardiorespiratory fitness, exercise intervention, cognitive impairment
- MeSH terms
- Cognition, Humans, Multiple Sclerosis, Quality of Life, Exercise, Randomized Controlled Trials as Topic
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