Two azafluoranthene alkaloids and a phytoecdysone from the stems of Cyclea barbata
Abstract
Two new azafluoranthene alkaloids (1 and 2), and a new phytoecdysone (3), were isolated from the stems of Cyclea barbata Miers, together with six known compounds (4-9). Their structures were elucidated by spectroscopic data analysis and comparison with published data. This is the first report of azafluoranthene alkaloids (1 and 2) and phytoecdysones (3, 8, and 9) from Cyclea genus. In in vitro bioassay, four isolates (3, 5, 6, and 9) showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells.
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Cycleasterone A showed moderate hepatoprotective activity against APAP-induced toxicity in HepG2 cells.
“Evaluated hepatoprotective activity against APAP-induced toxicity in HepG2 cells and moderate activity have been observed.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [135]
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The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115 · see citing works
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- Authors
- Wang, X.-J., Zhang, Q., Peng, Y.-R., Li, L., Qu, J., Liu, Y.-B., Xu, S., Ma, S.-G., Li, Y., Zou, Z.-M., Wang, R.-B., & Yu, S.-S.
- Affiliations
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
- Guangxi University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Yu, Shi-Shan
- Venue
- Journal of Asian Natural Products Research
- Publisher
- Informa UK Limited
- Published
- 2019-02-09
- Volume
- 21
- Issue
- 3
- Pages
- 217-226
- ISSN
- 1028-6020 (ISSN-L)
- 1477-2213
- OpenAlex
- W2913429906
- Cited by
- 9
- References
- 13
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 3 · 2020: 3
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Asian Natural Products Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundations of China
- Young Elite Scientists Sponsorship Program by CAST (QNRC001)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Traditional and Medicinal Uses of Annonaceae
- Keywords
- phytoecdysone, Cyclea barbata, natural product isolation, structure elucidation, hepatoprotection, HepG2 cells, stem
- MeSH terms
- Alkaloids, Antineoplastic Agents, Phytogenic, Cell Survival, Ecdysone, Humans, Models, Molecular, Phytosterols, Molecular Structure, Cyclea, Hep G2 Cells
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