The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Gender Issues in Depression
Abstract
BACKGROUND: Gender differences in depression have been documented for many years and thought to be insignificant to treatment selection until recently. METHODS: This article reviews gender differences in the prevalence, presentation, etiology, and antidepressant treatment of depressive disorders. RESULTS: The high female to male sex ratio in the prevalence of depression, especially during the reproductive years, is one of the most replicated findings in epidemiology. Women more often have a seasonal component, anxious and atypical depression. Explanations for the differences include psychological, neurochemical, anatomic, hormonal, genetic, and personality factors. Gender differences in antidepressant treatment response have not been found consistently. Hormonal status may be an important variable in addition to the effects of the menstrual cycle, pregnancy, perimenopause and menopause. CONCLUSIONS: Women have higher rates of depression and can often present differently than do men. Further research can ascertain which combination of factors increase women's risk. The effect of pregnancy and the impact of the menstrual cycle on the course of all depressive disorders need increased attention. Large prospective randomized controlled trials with gender differences in treatment response as the primary endpoint are necessary in order to answer the now controversial question of gender differences in antidepressant treatment response.
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Citations
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · cited 1×
“Although the high female to male sex ratio in the prevalence of depression, especially during the reproductive years, is one of the most replicated findings in epidemiology (1), the explanation remains uncertain.”
BackgroundHasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645
Burden of Disease—Implications for Future Research
Michaud, C. M. (2001) · JAMA · doi:10.1001/jama.285.5.535 · Cited by 594
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Entsuah, A. R., Huang, H., & Thase, M. E. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n1106 · Cited by 245
Relative antidepressant efficacy of venlafaxine and SSRIs: sex-age interactions
Thase, M. E., Entsuah, R., Cantillon, M., & Kornstein, S. G. (2005) · Journal of Women s Health · doi:10.1089/jwh.2005.14.609 · Cited by 201
A Longitudinal Twin Study of 1-Year Prevalence of Major Depression in Women
Kendler, K. S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820230009001 · Cited by 97
Remissions in Maternal Depression and Child Psychopathology: A STAR*D-Child Report
Weissman, M. M., Pilowsky, D. J., Wickramaratne, P. J., Talati, A., Wisniewski, S. R., Fava, M., Hughes, C. W., Garber, J., Malloy, E., King, C. A., et al. (2006) · JAMA · doi:10.1001/jama.295.12.1389 · Cited by 9
Cited by
Seedat, S., Scott, K. M., Angermeyer, M. C., Berglund, P., Bromet, E. J., Brugha, T. S., Demyttenaere, K., de Girolamo, G., Haro, J. M., Jin, R., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.36 · Cited by 1,518
Neuroinflammation and depression: A review
Troubat, R., Barone, P., Leman, S., Desmidt, T., Cressant, A., Atanasova, B., Brizard, B., El Hage, W., Surget, A., Belzung, C., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14720 · Cited by 1,107
The gender paradox in suicidal behavior and its impact on the suicidal process
Schrijvers, D. L., Bollen, J., & Sabbe, B. G. C. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.050 · Cited by 477
Porcelli, S., Fabbri, C., & Serretti, A. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.10.003 · Cited by 331
Cochran, S. D., & Mays, V. M. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0016501 · Cited by 293
Metadata
- Authors
- Grigoriadis, S., & Robinson, G. E.
- Venue
- Annals of Clinical Psychiatry
- Publisher
- SAGE Publications
- Published
- 2007-10
- Volume
- 19
- Issue
- 4
- Pages
- 247-255
- ISSN
- 1040-1237 (ISSN-L)
- 1547-3325
- OpenAlex
- W2143580415
- Cited by
- 272
- References
- 10
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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