Antihypertensive Peptides Derived from Egg Proteins
Open accessAbstract
There have been studies of antihypertensive peptides derived from food proteins, but very few described the production of bioactive peptides from egg proteins. The first 2 antihypertensive peptides isolated in egg were obtained by enzymatic hydrolysis of ovalbumin. They correspond to the sequences Phe-Arg-Ala-Asp-His-Pro-Phe-Leu (ovokinin) and Arg-Ala-Asp-His-Phe-Leu (ovokinin 2-7). Both exhibited endothelium-dependent vasodilatory activity. Ovokinin (2-7) had higher antihypertensive potency than ovokinin in spontaneously hypertensive rats (SHR). Modifications in the sequence of ovokinin (2-7) improved the bioavailability of this peptide. It was also demonstrated that different ovalbumin hydrolysates can inhibit angiotensin I-converting enzyme (ACE). We recently obtained an egg white hydrolysate that inhibited the enzyme in vitro. It was obtained by treating egg white with pepsin and it exhibited antihypertensive activity in SHR. Some ACE-inhibitory peptides obtained from this hydrolysate (Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe) also showed antihypertensive activity in these rats. The egg products mentioned could be used as functional food ingredients with potential therapeutic benefit in the prevention and treatment of hypertension.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Peptides with amino acid sequences Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe showed strong ACE inhibitory activities.
“Among the peptides with amino acid sequences of Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe showed strong ACE inhibitory activities.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel and Aleixandre, 2006
Miguel and Aleixandre (2006) produced peptides by hydrolyzing egg white with pepsin.
“Miguel and Aleixandre (2006) also produced peptides by hydrolyzing egg white with pepsin.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel and Aleixandre, 2006
Feeding these peptides to spontaneously hypertensive rats reduced blood pressure.
“Feeding these peptides to spontaneously hypertensive rats reduced blood pressure to the rats.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel and Aleixandre, 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Iroyukifujita, H., Eiichiyokoyama, K., & Yoshikawa, M. (2000) · Journal of Food Science · doi:10.1111/j.1365-2621.2000.tb16049.x · Cited by 543 · see citing works
Maeno, M., Yamamoto, N., & Takano, T. (1996) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(96)76487-1 · Cited by 392 · see citing works
Gobbetti, M., Stepaniak, L., De Angelis, M., Corsetti, A., & Di Cagno, R. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690290825538 · Cited by 344 · see citing works
Isolation and Structural Analysis of Antihypertensive Peptides That Exist Naturally in Gouda Cheese
Saito, T. T., Nakamura, T., Kitazawa, H., Kawai, Y., & Takatoshi, I. T. O. H. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)75013-2 · Cited by 341 · see citing works
Abubakar, A., Saito, T., Kitazawa, H., Kawai, Y., & Itoh, T. (1998) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(98)75878-3 · Cited by 330 · see citing works
Mullally, M. M., Meisel, H., & Fitzgerald, R. J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01503-7 · Cited by 253 · see citing works
Wu, J., & Ding, X. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000695n · Cited by 226 · see citing works
Miguel, M., Recio, I., Ruiz, J. Á. G., Ramos, M., & López‐Fandiño, R. (2004) · Journal of Food Protection · doi:10.4315/0362-028x-67.9.1914 · Cited by 216 · see citing works
Self-citationFujita, H., Yamagami, T., & Ohshima, K. (2001) · Nutrition Research · doi:10.1016/s0271-5317(01)00333-5 · Cited by 148 · see citing works
Miguel, M., Aleixandre, M. A., Ramos, M., & López‐Fandiño, R. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051101p · Cited by 142 · see citing works
Self-citationMatoba, N., Usui, H., Fujita, H., & Yoshikawa, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00587-6 · Cited by 137 · see citing works
Miguel, M., López‐Fandiño, R., Ramos, M., & Aleixandre, A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051570 · Cited by 128 · see citing works
Self-citationAntihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract
de Moura, R. S., Viana, F. S. C., de Souza, M. A. V., Kovary, K., Guedes, D., Oliveira, E. P. B., Rubenich, L. M. S., de Carvalho, L., de Oliveira, R. M. F., Tano, T., et al. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702153 · Cited by 122 · see citing works
Isolation and characterization of ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin
Fujita, H., Usui, H., Kurahashi, K., & Yoshikawa, M. (1995) · Peptides · doi:10.1016/0196-9781(95)00054-n · Cited by 104 · see citing works
Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks
Yoshii, H., Tachi, N., Ohba, R., Sakamura, O., 武山, 英., & Itani, T. (2001) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(00)00172-1 · Cited by 102 · see citing works
Fujita, H., Sasaki, R., & Yoshikawa, M. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.2344 · Cited by 100 · see citing works
Design of a Highly Potent Anti-hypertensive Peptide Based on Ovokinin(2-7)
Yamada, Y., Matoba, N., Usui, H., Onishi, K., & Yoshikawa, M. (2002) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.66.1213 · Cited by 74 · see citing works
Matoba, N., Doyama, N., Yamada, Y., Maruyama, N., Utsumi, S., & Yoshikawa, M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02434-6 · Cited by 70 · see citing works
Designing Potent Derivatives of Ovokinin(2-7), an Anti-hypertensive Peptide Derived from Ovalbumin
Matoba, N., Yamada, Y., Usui, H., NAKAGIRI, R., & Yoshikawa, M. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.736 · Cited by 50 · see citing works
Onishi, K., Matoba, N., Yamada, Y., Doyama, N., Maruyama, N., Utsumi, S., & Yoshikawa, M. (2004) · Peptides · doi:10.1016/j.peptides.2003.11.006 · Cited by 37 · see citing works
Antihypertensive Properties of Spinach Leaf Protein Digests
Yang, Y., Marczak, E. D., Usui, H., Kawamura, Y., & Yoshikawa, M. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034551v · Cited by 35 · see citing works
Chen, T.-L., Lo, Y.-C., Hu, W.-T., WU, M. C., Chen, S., & Chang, H. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020900u · Cited by 30 · see citing works
Interaction of ovokinin(2–7) with vascular bradykinin 2 receptors
Scruggs, P., Filipeanu, C. M., Yang, J., Chang, J. K., & Dun, N. J. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.02.019 · Cited by 27 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Miguel M, Ramos M, Aleixandre MA, Lo ´pez-Fandio R. Antihypertensive peptides obtained from egg white proteins by enzymatic hydrolysis. Stability under simulated gastrointestinal digestion. J Agric Food Chem. 2006;54:726-31.
- Miguel M, Lo ´pez-Fandio R, Ramos M, Aleixandre MA. Long-term antihypertensive effect of egg white treated with pepsin in hypertensive rats. Life Sci. In press 2006.
Cited by
Sorted by citations
Food-derived peptides with biological activity: from research to food applications.
Hartmann, R., & Meisel, H. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.01.013 · Cited by 1,102 · see citing works
Algal Proteins: Extraction, Application, and Challenges Concerning Production
Bleakley, S., & Hayes, M. (2017) · Foods · doi:10.3390/foods6050033 · Cited by 1,092 · see citing works
Abeyrathne, E. D. N. S., Lee, H. Y., & Ahn, D. U. (2013) · Poultry Science · doi:10.3382/ps.2013-03391 · Cited by 510 · see citing works
Iwaniak, A., Mińkiewicz, P., & Darewicz, M. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12051 · Cited by 319 · see citing works
Antihypertensive peptides from food proteins: a review
Martínez‐Maqueda, D., Miralles, B., Recio, I., & Hernández‐Ledesma, B. (2012) · Food & Function · doi:10.1039/c2fo10192k · Cited by 281 · see citing works
The chicken egg white proteome
Mann, K. (2007) · PROTEOMICS · doi:10.1002/pmic.200700397 · Cited by 246 · see citing works
The antihypertensive effect of peptides: A novel alternative to drugs?
Hong, F., Luo, M., Sheng, Y., Li, Z., Yongquan, W., & Chi, L. (2008) · Peptides · doi:10.1016/j.peptides.2008.02.005 · Cited by 244 · see citing works
Peptides: Production, bioactivity, functionality, and applications
Hajfathalian, M., Ghelichi, S., García‐Moreno, P. J., Sørensen, A. M., & Jacobsen, C. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1352564 · Cited by 205 · see citing works
Plant Food-Derived Angiotensin I Converting Enzyme Inhibitory Peptides
Guang, C., & Phillips, R. D. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900494d · Cited by 196 · see citing works
Plant proteases for bioactive peptides release: A review
Mazorra-Manzano, M. A., Ramírez‐Suárez, J. C., & Yada, R. Y. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1308312 · Cited by 191 · see citing works
Exploring the Chicken Egg White Proteome with Combinatorial Peptide Ligand Libraries
DˈAmbrosio, C., Arena, S., Scaloni, A., Guerrier, L., Boschetti, E., Mendieta, M. E., Citterio, A., & Righetti, P. G. (2008) · Journal of Proteome Research · doi:10.1021/pr800193y · Cited by 174 · see citing works
Bioactive Food Peptides in Health and Disease
Hernandez-Ledesma, B., & Hsieh, C. (2013) · InTech eBooks · doi:10.5772/3318 · Cited by 168 · see citing works
Majumder, K., & Wu, J. (2010) · Food Research International · doi:10.1016/j.foodres.2010.04.027 · Cited by 167 · see citing works
Majumder, K., & Wu, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010256 · Cited by 168 · see citing works
Huang, W.-Y., Davidge, S. T., & Wu, J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.550071 · Cited by 157 · see citing works
ACE-inhibitory and antihypertensive properties of a bovine casein hydrolysate
Miguel, M., Contreras, M. D. M., Recio, I., & Aleixandre, A. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.05.041 · Cited by 151 · see citing works
Self-citationEgg-Derived Tri-Peptide IRW Exerts Antihypertensive Effects in Spontaneously Hypertensive Rats
Majumder, K., Chakrabarti, S., Morton, J. S., Panahi, S., Kaufman, S., Davidge, S. T., & Wu, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082829 · Cited by 150 · see citing works
Egg Bioscience and Biotechnology
(2007) · Wiley eBooks · doi:10.1002/9780470181249 · Cited by 153 · see citing works
Sun‐Waterhouse, D., Zhao, M., & Waterhouse, G. I. N. (2014) · Food and Bioprocess Technology · doi:10.1007/s11947-014-1326-6 · Cited by 139 · see citing works
Lin, L., Lv, S., & Li, B. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.08.064 · Cited by 134 · see citing works
Burd, N. A., Beals, J. W., Martinez, I. G., Salvador, A. F., & Skinner, S. K. (2019) · Sports Medicine · doi:10.1007/s40279-018-1009-y · Cited by 127 · see citing works
Miguel, M., Dávalos, A., Manso-Silván, M. A., de la Peña, G., Lasunción, M. A., & López‐Fandiño, R. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700503 · Cited by 127 · see citing works
Self-citationLiu, J., Yu, Z., Zhao, W., Lin, S., Wang, E., Zhang, Y., Hao, H., Wang, Z., & Chen, F. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.03.108 · Cited by 123 · see citing works
Bioactive peptides derived from egg proteins: A review
Liu, Y., Oey, I., Bremer, P. J., Carne, A., & Silcock, P. J. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1329704 · Cited by 156 · see citing works
Antioxidant activity of protein hydrolysates and purified peptides from Zizyphus jujuba fruits
Memarpoor‐Yazdi, M., Mahaki, H., & Zare‐Zardini, H. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.08.004 · Cited by 119 · see citing works
Current In Vitro Testing of Bioactive Peptides Is Not Valuable
Foltz, M., van der Pijl, P. C., & Duchateau, G. S. M. J. E. (2009) · Journal of Nutrition · doi:10.3945/jn.109.116228 · Cited by 114 · see citing works
Egg proteins: fractionation, bioactive peptides and allergenicity
Chang, C., Lahti, T., Tanaka, T., & Nickerson, M. T. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9150 · Cited by 112 · see citing works
Majumder, K., & Wu, J. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8028557 · Cited by 108 · see citing works
Huang, W.-H., Sun, J., He, H., Dong, H.-W., & Li, J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.03.127 · Cited by 103 · see citing works
Therapeutic Peptides: Recent Advances in Discovery, Synthesis, and Clinical Translation
Zheng, B., Wang, X., Guo, M., & Tzeng, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115131 · Cited by 103 · see citing works
Majumder, K., Chakrabarti, S., Morton, J. S., Panahi, S., Kaufman, S., Davidge, S. T., & Wu, J. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.028 · Cited by 102 · see citing works
Meat proteome as source of functional biopeptides
Udenigwe, C. C., & Howard, A. (2012) · Food Research International · doi:10.1016/j.foodres.2012.10.002 · Cited by 96 · see citing works
ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties
Sieber, R., Bütikofer, U., Egger, L., Portmann, R., Walther, B., & Wechsler, D. (2009) · Dairy Science and Technology · doi:10.1051/dst/2009049 · Cited by 95 · see citing works
An antioxidant peptide derived from Ostrich (Struthio camelus) egg white protein hydrolysates
Tanzadehpanah, H., Asoodeh, A., & Chamani, J. (2012) · Food Research International · doi:10.1016/j.foodres.2012.08.022 · Cited by 95 · see citing works
Antihypertensive Peptides from Food Proteins
Norris, R., & Richard, J. (2013) · InTech eBooks · doi:10.5772/51710 · Cited by 95 · see citing works
Martin, M., & Deußen, A. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1402750 · Cited by 94 · see citing works
Miguel, M., Manso-Silván, M. A., Aleixandre, A., Alonso, M. J., Salaíces, M., & López‐Fandiño, R. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072307o · Cited by 91 · see citing works
Self-citationMajumder, K., Liang, G., Chen, Y., Guan, L. L., Davidge, S. T., & Wu, J. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500050 · Cited by 89 · see citing works
Vasodilator effects of peptides derived from egg white proteins
Miguel, M., Álvarez, Y., López‐Fandiño, R., Alonso, M. J., & Salaíces, M. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2006.11.029 · Cited by 81 · see citing works
Self-citationFood‐derived immunomodulatory peptides
Santiago‐López, L., Hernández‐Mendoza, A., Vallejo‐Córdoba, B., Mata‐Haro, V., & González-Córdova, A. F. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7697 · Cited by 81 · see citing works
Bleakley, S., Hayes, M., Shea, N. O., Gallagher, E., & Lafarga, T. (2017) · Foods · doi:10.3390/foods6120108 · Cited by 81 · see citing works
Zhang, Y., & Zhang, D. (2018) · Journal of Human Hypertension · doi:10.1038/s41371-018-0068-8 · Cited by 78 · see citing works
Miguel, M., Ruiz, J. Á. G., Recio, I., & Aleixandre, A. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900448 · Cited by 77 · see citing works
Self-citationGallego, M., Grootaert, C., Mora, L., Aristoy, M., Camp, J. V., & Toldrá, F. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2015.11.046 · Cited by 76 · see citing works
Tanzadehpanah, H., Asoodeh, A., Saberi, M. R., & Chamani, J. (2013) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2013.02.002 · Cited by 71 · see citing works
Advanced Practical Strategies to Enhance Table Egg Production
El‐Sabrout, K., Aggag, S. A., & Mishra, B. (2022) · Scientifica · doi:10.1155/2022/1393392 · Cited by 70 · see citing works
Asoodeh, A., Memarpoor‐Yazdi, M., & Chamani, J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.08.039 · Cited by 69 · see citing works
Banerjee, P., & Shanthi, C. (2012) · Process Biochemistry · doi:10.1016/j.procbio.2012.09.012 · Cited by 69 · see citing works
Dave, L. A., Hayes, M., Montoya, C. A., Rutherfurd, S. M., & Moughan, P. J. (2015) · Peptides · doi:10.1016/j.peptides.2015.11.003 · Cited by 64 · see citing works
Biological and functional properties of proteolytic enzyme‐modified egg protein by‐products
Pokora, M., Eckert, E., Zambrowicz, A., Bobak, Ł., Szołtysik, M., Dąbrowska, A., Chrzanowska, J., Polanowski, A., & Trziszka, T. (2013) · Food Science & Nutrition · doi:10.1002/fsn3.27 · Cited by 63 · see citing works
Peptides Derived from Foods as Supportive Diet Components in the Prevention of Metabolic Syndrome
Iwaniak, A., Darewicz, M., & Mińkiewicz, P. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12321 · Cited by 63 · see citing works
Effect of high pressure treatment on egg white protein digestibility and peptide products
Hoppe, A., Jung, S., Patnaik, A., & Zeece, M. G. (2012) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2012.11.003 · Cited by 62 · see citing works
Zhang, M., Zhao, Y., Yao, Y., Xu, M., Du, H., Wu, N., & Tu, Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.019 · Cited by 62 · see citing works
Wu, S., Feng, X., Lan, X., Xu, Y., & Liao, D. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.051 · Cited by 60 · see citing works
QIGLF, a novel angiotensin I‐converting enzyme‐inhibitory peptide from egg white protein
Yu, Z., Zhao, W., Liu, J., Lu, J., & Chen, F. (2011) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4266 · Cited by 60 · see citing works
Facile Fabrication of Egg White Macroporous Sponges for Tissue Regeneration
Jalili‐Firoozinezhad, S., Rajabi, S., Mohammadi, P., Gaudiello, E., Bonakdar, S., Solati‐Hashjin, M., Marsano, A., Aghdami, N., Scherberich, A., Baharvand, H., et al. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500482 · Cited by 60 · see citing works
Enzymatic hydrolysis of ovalbumin and the functional properties of the hydrolysates
Abeyrathne, E. D. N. S., Lee, H. Y., Jo, C., Nam, K., & Ahn, D. U. (2014) · Poultry Science · doi:10.3382/ps.2014-04155 · Cited by 59 · see citing works
Biochemical requirements of bioactive peptides for nutraceutical efficacy
Gianfranceschi, G. L., Gianfranceschi, G., Quassinti, L., & Bramucci, M. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.034 · Cited by 58 · see citing works
Functions and Applications of Bioactive Peptides From Corn Gluten Meal
Li, G., Liu, W., Wang, Y., Jia, F., Wang, Y., Ma, Y., Gu, R., & Lu, J. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2018.07.001 · Cited by 60 · see citing works
Abeyrathne, E. D. N. S., Lee, H. Y., Jo, C., Suh, J., & Ahn, D. U. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.06.055 · Cited by 53 · see citing works
Rao, S., Ju, T., Sun, J. S., Su, Y., Xu, R., & Yang, Y. (2011) · Food Research International · doi:10.1016/j.foodres.2011.12.005 · Cited by 50 · see citing works
Potential Applications of Food Derived Bioactive Peptides in Management of Health
Dhaval, A., Yadav, N., & Purwar, S. (2016) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-016-9514-z · Cited by 51 · see citing works
Designing vascular supportive albumen-rich composite bioink for organ 3D printing
Liu, S., Zhang, H., Hu, Q., Shen, Z., Rana, D., & Ramalingam, M. (2020) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2020.103642 · Cited by 49 · see citing works
Egg-derived peptides and hydrolysates: A new bioactive treasure for cardiometabolic diseases
Moreno-Fernández, S., Garcés‐Rimón, M., & Miguel, M. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.08.002 · Cited by 49 · see citing works
Self-citationYu, Z., Yin, Y., Zhao, W., Chen, F., & Liu, J. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6670 · Cited by 46 · see citing works
Structure and ACE-Inhibitory Activity of Peptides Derived from Hen Egg White Lysozyme
Memarpoor‐Yazdi, M., Asoodeh, A., & Chamani, J. (2012) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-012-9311-2 · Cited by 43 · see citing works
Nutritional significance and health benefits of designer eggs
Alagawany, M. M., Farag, M. R., Dhama, K., & Patra, A. K. (2018) · World s Poultry Science Journal · doi:10.1017/s0043933918000041 · Cited by 45 · see citing works
Jahandideh, F., Majumder, K., Chakrabarti, S., Morton, J. S., Panahi, S., Kaufman, S., Davidge, S. T., & Wu, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115006 · Cited by 42 · see citing works
The Family Secrets of Avian Egg-Specific Ovalbumin and Its Related Proteins Y and X
da Silva, M., Beauclercq, S. A., Harichaux, G., Labas, V., Guyot, N., Gautron, J., Nys, Y. Y., & Réhault‐Godbert, S. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.130856 · Cited by 41 · see citing works
One-Week Antihypertensive Effect of Ile-Gln-Pro in Spontaneously Hypertensive Rats
Lu, J., Sawano, Y., Miyakawa, T., Xue, Y. Y., Cai, M.-Y., Egashira, Y., Ren, D., & Tanokura, M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf104126a · Cited by 38 · see citing works
Krichen, F., Sila, A., Caron, J., Kobbi, S., Nedjar, N., Miled, N., Blecker, C. S., Besbes, S., & Bougatef, A. (2018) · Engineering in Life Sciences · doi:10.1002/elsc.201800045 · Cited by 38 · see citing works
Luo, J., Zhang, C., Liu, Q., Ou, S., Zhang, L., & Peng, X. (2017) · Food Research International · doi:10.1016/j.foodres.2017.07.019 · Cited by 37 · see citing works
Enzymatic hydrolysis of ovomucoid and the functional properties of its hydrolysates
Abeyrathne, E. D. N. S., Lee, H. Y., Jo, C., Suh, J., & Ahn, D. U. (2015) · Poultry Science · doi:10.3382/ps/pev196 · Cited by 37 · see citing works
Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome
Jahandideh, F., & Wu, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062192 · Cited by 36 · see citing works
Lunow, D., Kaiser, S., Brückner, S. I., Gotsch, A., & Henle, T. (2013) · European Food Research and Technology · doi:10.1007/s00217-013-2014-x · Cited by 35 · see citing works
Mora, L., & Hayes, M. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf505019z · Cited by 33 · see citing works
Zhou, C., Wu, Q., Ye, Z., Liu, M., Zhang, Z., Zhang, Y., Li, H., He, P., Li, Q., Liu, C., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18222 · Cited by 34 · see citing works
Nowacki, D., Martynowicz, H., Skoczyńska, A., Wojakowska, A., Turczyn, B., Bobak, Ł., Trziszka, T., & Szuba, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-12019-w · Cited by 32 · see citing works
Biologically active peptides derived from egg proteins
Eckert, E., Zambrowicz, A., Pokora, M., Polanowski, A., Chrzanowska, J., Szołtysik, M., Dąbrowska, A., Różański, H., & Trziszka, T. (2013) · World s Poultry Science Journal · doi:10.1017/s0043933913000366 · Cited by 33 · see citing works
Fernández, M., Benito, M. J., Martı́n, A., Casquete, R., Córdoba, J. J., & Córdoba, M. D. G. (2016) · Heliyon · doi:10.1016/j.heliyon.2016.e00093 · Cited by 32 · see citing works
Santana, A. C. D. T., Melo, A., Tavares, T. G., & Ferreira, I. M. P. L. V. O. (2016) · Food & Function · doi:10.1039/c6fo00954a · Cited by 31 · see citing works
Nutritional, Functional and Bioactive Protein Hydrolysates
Liceaga, A., & Hall, F. (2019) · Encyclopedia of Food Chemistry · doi:10.1016/b978-0-08-100596-5.21776-9 · Cited by 14 · see citing works
Bioactive Proteins and Peptides from Egg Proteins
Wu, J., Majumder, K., & Gibbons, K. (2010) · Wiley eBooks · doi:10.1002/9780813811048.ch17 · Cited by 27 · see citing works
Golzarand, M., Bahadoran, Z., Mirmiran, P., & Azizi, F. (2016) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2016.01.017 · Cited by 26 · see citing works
Kaewmanee, T., Benjakul, S., & Visessanguan, W. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01305.x · Cited by 26 · see citing works
Sequential Separation of Lysozyme and Ovalbumin from Chicken Egg White
Abeyrathne, N. S., Lee, H. Y., & Ahn, D. U. (2013) · Korean Journal for Food Science of Animal Resources · doi:10.5851/kosfa.2013.33.4.501 · Cited by 25 · see citing works
Facile modification of polycaprolactone nanofibers with egg white protein
Renkler, N. Z., Ergene, E., Gökyer, Ş., Öztürk, M. T., Huri, P. Y., & Tuzlakoğlu, K. (2021) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-021-06505-x · Cited by 24 · see citing works
Wang, J., Liu, Y.-L., Ning, J., Yu, J., Li, X., & Wang, F. (2013) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2013.03.004 · Cited by 23 · see citing works
Dave, L. A., Hayes, M., Mora, L., Montoya, C. A., Moughan, P. J., & Rutherfurd, S. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040482 · Cited by 23 · see citing works
Lucey, A. J., Heneghan, C., Manning, E., Kroon, P. A., & Kiely, M. E. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1832-9 · Cited by 23 · see citing works
Shukla, P., Chopada, K., Sakure, A. A., & Hati, S. (2022) · Protein and Peptide Letters · doi:10.2174/0929866529666220106100225 · Cited by 21 · see citing works
Bioactive Peptides from Legumes and Their Bioavailability
Indrati, R. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99979 · Cited by 21 · see citing works
Li, Y., Wang, B., Zhang, H., Wang, Z., Zhu, S., & Ma, H. (2015) · Process Biochemistry · doi:10.1016/j.procbio.2015.01.017 · Cited by 20 · see citing works
Les activités biologiques de l’œuf
Réhault‐Godbert, S., Anton, M., Nau, F., Gautron, J., & Nys, Y. Y. (2007) · INRAE Productions Animales · doi:10.20870/productions-animales.2007.20.4.3470 · Cited by 21 · see citing works
Chakrabarti, S., Ren, J., & Wu, J. (2020) · Nutrients · doi:10.3390/nu12102998 · Cited by 19 · see citing works
Fried egg digest decreases blood pressure in spontaneous hypertensive rats
Majumder, K., Panahi, S., Kaufman, S., & Wu, J. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.10.004 · Cited by 18 · see citing works
Nutritional Aspects of Eggs for a Healthy and Sustainable Consumption: A Narrative Review
Caffa, I., Proietti, E., Turrini, F., Borgarelli, C., Ferrando, M. R., Formisano, E., Neri, L. D. C. L., Martini, D., Angelino, D., Tagliabue, A., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70285 · Cited by 17 · see citing works
Cho, H. Y., Lee, J., Lee, J. H., Ahn, D. U., & Paik, H. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105487 · Cited by 17 · see citing works
Wang, K., Wang, J., Zhao, P., Lin, S., Liu, B., Liu, J., Jones, G. S., & Huang, H. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.07.020 · Cited by 17 · see citing works
Antioxidative capacity of hydrolysates of hen egg proteins
Graszkiewicz, A., Żelazko, M., Trziszka, T., & Polanowski, A. (2007) · Polish Journal of Food and Nutrition Sciences · Cited by 16 · see citing works
- Authors
- Miguel, M., & Aleixandre, A.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Aleixandre, Amaya
- ORCID
- Miguel, Marta
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 136
- Issue
- 6
- Pages
- 1457-1460
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1892558259
- Cited by
- 168
- References
- 23
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 3 · 2018: 14 · 2017: 14 · 2016: 9 · 2015: 18 · 2014: 8 · 2013: 16 · 2012: 14
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion, other-oa)
- Funders
- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- antihypertensive peptides, egg proteins, ovalbumin, enzymatic hydrolysis, angiotensin-converting enzyme inhibition, endothelium-dependent vasodilation, egg white hydrolysate, pepsin hydrolysis, bioactive peptides, hypertension, functional food ingredients, spontaneously hypertensive rats
- MeSH terms
- Animals, Antihypertensive Agents, Egg Proteins, Hypertension, Ovalbumin, Peptide Fragments, Rats, Inbred SHR, Rats, Inbred WKY, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review