Cited by 168Protein Hydrolysis and Bioactive PeptidesPeptidase Inhibition and AnalysisRenin-Angiotensin System Studies

Antihypertensive Peptides Derived from Egg Proteins

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Miguel, Marta, Aleixandre, Amaya·2006·The Journal of Nutrition

Abstract

There have been studies of antihypertensive peptides derived from food proteins, but very few described the production of bioactive peptides from egg proteins. The first 2 antihypertensive peptides isolated in egg were obtained by enzymatic hydrolysis of ovalbumin. They correspond to the sequences Phe-Arg-Ala-Asp-His-Pro-Phe-Leu (ovokinin) and Arg-Ala-Asp-His-Phe-Leu (ovokinin 2-7). Both exhibited endothelium-dependent vasodilatory activity. Ovokinin (2-7) had higher antihypertensive potency than ovokinin in spontaneously hypertensive rats (SHR). Modifications in the sequence of ovokinin (2-7) improved the bioavailability of this peptide. It was also demonstrated that different ovalbumin hydrolysates can inhibit angiotensin I-converting enzyme (ACE). We recently obtained an egg white hydrolysate that inhibited the enzyme in vitro. It was obtained by treating egg white with pepsin and it exhibited antihypertensive activity in SHR. Some ACE-inhibitory peptides obtained from this hydrolysate (Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe) also showed antihypertensive activity in these rats. The egg products mentioned could be used as functional food ingredients with potential therapeutic benefit in the prevention and treatment of hypertension.

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  1. Miguel M, Ramos M, Aleixandre MA, Lo ´pez-Fandio R. Antihypertensive peptides obtained from egg white proteins by enzymatic hydrolysis. Stability under simulated gastrointestinal digestion. J Agric Food Chem. 2006;54:726-31.
  2. Miguel M, Lo ´pez-Fandio R, Ramos M, Aleixandre MA. Long-term antihypertensive effect of egg white treated with pepsin in hypertensive rats. Life Sci. In press 2006.

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Authors
Miguel, M., & Aleixandre, A.
Affiliations
Universidad Complutense de Madrid (ES)
Corresponding author
Aleixandre, Amaya
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2006-06
Volume
136
Issue
6
Pages
1457-1460
ISSN
0022-3166 (ISSN-L)
OpenAlex
W1892558259
Cited by
168
References
23
Citations by year
2026: 1 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 3 · 2018: 14 · 2017: 14 · 2016: 9 · 2015: 18 · 2014: 8 · 2013: 16 · 2012: 14
FWCI
2.18
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion, other-oa)
Funders
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
  • Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
antihypertensive peptides, egg proteins, ovalbumin, enzymatic hydrolysis, angiotensin-converting enzyme inhibition, endothelium-dependent vasodilation, egg white hydrolysate, pepsin hydrolysis, bioactive peptides, hypertension, functional food ingredients, spontaneously hypertensive rats
MeSH terms
Animals, Antihypertensive Agents, Egg Proteins, Hypertension, Ovalbumin, Peptide Fragments, Rats, Inbred SHR, Rats, Inbred WKY, Rats

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