The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Systematic evaluation on the effectiveness of conjugated linoleic acid in human health
Abstract
The term CLA (conjugated linoleic acid) corresponds to a mixture of positional and geometric isomers of linoleic acid. Two of these isomers (9c, 11t and 10t, 12c) have biological activity. The milk and dairy products are the most abundant source of conjugated linoleic acid, which refers to a group of positional and geometric isomers of CLA (CLA 18:2 cis-9, cis-12). The following research aims to approach aspects regarding the CLA, as well as its relationship with diseases. Conjugated linoleic acids have been studied for their beneficial effects in the prevention and treatment of many diseases, including obesity, cancer, diabetes, and cardiovascular diseases. Scientific information put together the physiological properties of CLA, which serves as inputs to claim their potential as functional ingredients to be used in the prevention and control of several chronic metabolic disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“CLA has several functional properties and potential health-promoting effects, such as anticarcinogenic, anti-inflammatory, reducing and preventing body fat deposition, reducing atherosclerosis [261,262], modulating the immune system [263], reducing blood glucose levels [264], reducing osteoporosis [265], preventing and treating cardiovascular disease, controlling serum levels of cholesterol and”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [264]
In the citing paper
“CLA is found in many foods, in greater amounts in milk, dairy products, and beef, and in lesser amounts in pork, poultry, and vegetable oils [264].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [264]
Citations
Cites
Effect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163
Conjugated Linoleic Acid Is Synthesized Endogenously in Lactating Dairy Cows by Δ9-Desaturase
Griinari, J. M., Nurmela, K., Corl, B. A., Lacy, S. H., Chouinard, P. Y., & Bauman, D. E. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2285 · Cited by 1,054
Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid
Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1987) · Carcinogenesis · doi:10.1093/carcin/8.12.1881 · Cited by 929
Mammary cancer prevention by conjugated dienoic derivative of linoleic acid.
Ip, C., Chin, S. F., Scimeca, J. A., & Pariza, M. W. (1991) · PubMed · Cited by 743
Advances in Conjugated Linoleic Acid Research
Sébédio, J., Christie, W. W., & Adlof, R. O. (2020) · AOCS Publishing eBooks · doi:10.4324/9780429270703 · Cited by 710
Biological effects of conjugated linoleic acids in health and disease
Bhattacharya, A., Banu, J., Rahman, M., Causey, J., & Fernandes, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.009 · Cited by 663
Conjugated Linoleic Acid Reduces Body Fat Mass in Overweight and Obese Humans
Gudmundsen, O., Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., & Wadstein, J. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.2943 · Cited by 595
Conjugated linoleic acids: are they beneficial or detrimental to health?
Wahle, K. W. J., Heys, S. D., & Rotondo, D. (2004) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.08.002 · Cited by 505
Conjugated Linoleic Acid and Other Anticarcinogenic Agents of Bovine Milk Fat
Parodi, P. W. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75358-0 · Cited by 421
The role of Δ9-desaturase in the production of cis-9, trans-11 CLA
Corl, B. A., Baumgard, L. H., Dwyer, D. A., Griinari, J. M., Phillips, B. S., & Bauman, D. E. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00180-2 · Cited by 408
Research works printed but not linked: 13
- Atkinson R., 1999, AOCS Press, 1, 348
- Collomb M., 2000, Mitteilungen Lebensmit Hygiene., 91, 306
- Funck L. G., 2006, Arch. Latinoam. Nutr., 56, 123
- Gaze B. S., 2007, Rev. Bras Obes. Nutr. Emagrecimento, 1, 48
- Gómez-Candela C., 2004, Nut. Clín., Diet Hospitalaria., 24, 55
- Hajes V., 2003, Nutr. Cancer., 1, 17
- Hargraves W. A., 1983, Cancer Res., 43, 1467
- Ip C., 1991, Cancer Res., 51, 6118
- Kelly G. S., 2001, Altern. Med. Rev, 6, 367
- Medeiros S. R., 2002, Ácido linoléico conjugado: Teores nos alimentos e seu uso no aumento da produção de leite com maior teor de proteína e perfil de ácidos graxos modificado
- Pariza M. W., 2001, Proc. Soc. Exp. Boil. Med., 223, 8
- Park Y., 2009, J. Food Comp. Anal., 10, 1
- Yucawecz M. P., 1999, AOCS Press., 1, 397
Cited by
Sorted by citations
Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions
Coelho, M. C., Malcata, F. X., & Silva, C. C. G. (2022) · Foods · doi:10.3390/foods11152276 · Cited by 276
“CLA is found in many foods, in greater amounts in milk, dairy products, and beef, and in lesser amounts in pork, poultry, and vegetable oils [264].”
Milk fatty acids and potential health benefits: An updated vision
Gómez‐Cortés, P., Juárez, M., & de la Fuente, M. Á. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.08.014 · Cited by 260
Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin
Huang, T.-H., Wang, P.-W., Yang, S.-C., Chou, W.-L., & Fang, J.-Y. (2018) · Marine Drugs · doi:10.3390/md16080256 · Cited by 210
Fontecha, J., Calvo, M. V., Juárez, M., Gil, Á., & Martínez‐Vizcaíno, V. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy099 · Cited by 171
Branched-Chain Fatty Acids—An Underexplored Class of Dairy-Derived Fatty Acids
Taormina, V. M., Unger, A. L., Schiksnis, M. R., Torres‐Gonzalez, M., & Kraft, J. (2020) · Nutrients · doi:10.3390/nu12092875 · Cited by 166
Metadata
- Authors
- Fuke, G., & Nornberg, J. L.
- Affiliations
- Universidade Federal de Santa Maria (BR)
- Departamento de Ciência e Tecnologia de Alimentos Endereço, Endereço, Campus Universitário - Centro de Ciências Rurais Prédio, Santa Maria, Brazil
- Corresponding author
- Fuke, Gitane
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2016-09-16
- Volume
- 57
- Issue
- 1
- Pages
- 1-7
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2520860049
- Cited by
- 137
- References
- 69
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 15 · 2023: 15 · 2022: 20 · 2021: 18 · 2020: 16 · 2019: 18 · 2018: 16 · 2017: 4
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- conjugated linoleic acid, CLA isomers, dairy products, functional food ingredients, obesity, cancer, diabetes mellitus, cardiovascular disease, chronic metabolic disorders, disease prevention
- MeSH terms
- Animals, Body Composition, Chronic Disease, Dairy Products, Humans, Insulin Resistance, Stereoisomerism, Molecular Structure, Anticarcinogenic Agents, Evidence-Based Medicine, Dietary Supplements, Linoleic Acids, Conjugated, Lipid Metabolism, Functional Food
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review