EURRECA—Estimating Selenium Requirements for Deriving Dietary Reference Values
Abstract
Current reference values for selenium, an essential micronutrient, are based on the intake of selenium that is required to achieve maximal glutathione peroxidase activity in plasma or erythrocytes. In order to assess the evidence of relevance to setting dietary reference values for selenium, the EURRECA Network of Excellence focused on systematic searches, review, and evaluation of (i) selenium status biomarkers and evidence for relationships between intake and status biomarkers, (ii) selenium and health (including the effect of intake and/or status biomarkers on cancer risk, immune function, HIV, cognition, and fertility), (iii) bioavailability of selenium from the diet, and (iv) impact of genotype/single nucleotide polymorphisms on status or health outcomes associated with selenium. The main research outputs for selenium and future research priorities are discussed further in this review.
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SeMet and SeCys have direct antioxidant functions and fulfill essential physiological functions through deliberate incorporation of SeCys into Se-proteins.
“The amino acids SeMet and SeCys are pivotal Se molecules because they have direct antioxidant functions and fulfill a number of essential physiological functions through deliberate incorporation of SeCys into Se-proteins [197,198,199].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [199]
Cites
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563 · see citing works
Graat, J. M., Schouten, E. G., & Kok, F. J. (2002) · JAMA · doi:10.1001/jama.288.6.715 · Cited by 230 · see citing works
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Selenium for preventing cancer
Vinceti, M., Filippini, T., Del Giovane, C., Dennert, G., Zwahlen, M., Brinkman, M., Zeegers, M. P., Horneber, M., D'Amico, R., & Crespi, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub4 · Cited by 649 · see citing works
Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review
Winkel, L., Vriens, B., Jones, G., Schneider, L., Pilon-Smits, E., & Bañuelos, G. (2015) · Nutrients · doi:10.3390/nu7064199 · Cited by 476 · see citing works
- Authors
- Hurst, R., Collings, R., Harvey, L. J., King, M., Hooper, L., Bouwman, J., Gurinovic, M., & Fairweather-Tait, S. J.
- Affiliations
- University of East Anglia (GB)
- Netherlands Organisation for Applied Scientific Research (NL)
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2013-01
- Volume
- 53
- Issue
- 10
- Pages
- 1077-1096
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W4211007045
- Cited by
- 110
- References
- 2
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 18 · 2020: 14 · 2019: 6 · 2018: 13 · 2017: 8 · 2016: 5 · 2015: 11 · 2014: 6 · 2013: 4
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- TNO Repository (submittedVersion)
- RIMI (Institute for Medical Research, University of Belgrade) (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BBS/E/F/00042669)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Organoselenium and organotellurium chemistry
- Keywords
- selenium, dietary reference values, selenium requirement, selenium status biomarkers, glutathione peroxidase, selenium bioavailability, single nucleotide polymorphisms, genetic susceptibility, cancer risk, immune function, HIV, cognition, fertility, micronutrients
- MeSH terms
- Humans, Nutritional Status, Reference Values, Selenium, Biomarkers, Nutrition Assessment, Randomized Controlled Trials as Topic, Nutrition Policy, Evidence-Based Medicine, Dietary Supplements, Recommended Dietary Allowances
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