Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons: A Randomized Controlled Trial
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Context Immune response in elderly individuals has been reported to improve after micronutrient supplementation. However, efficacy trials evaluating infectious diseases as outcomes are scarce and inconclusive. Objective To investigate the effect of daily multivitamin-mineral and vitamin E supplementation on incidence and severity of acute respiratory tract infections in elderly individuals. Design A randomized, double blind, placebo-controlled, 2 x 2 factorial trial. Setting and participants A total of 652 noninstitutionalized individuals aged 60 years or older enrolled from 2 community-based sampling strategies in the Wageningen area of the Netherlands, conducted from 1998 to 2000. At baseline, 6% of participants had suboptimal ascorbic acid and 1.3% had suboptimal alpha-tocopherol plasma concentration. Intervention Physiological doses of multivitamin-minerals, 200 mg of vitamin E, both, or placebo. Main outcome measures Incidence and severity of self-reported acute respiratory tract infections at 15 months, as assessed by a nurse (telephone contact), home visits, and microbiological and serological testing in subsets of patients. Results During a median observation period of 441 days, 443 (68%) of 652 participants recorded 1024 respiratory tract infection episodes. The incidence rate ratio of acute respiratory tract infection for multivitamin-mineral supplementation was 0.95 (95% confidence interval, 0.75-1.15; P =.58) and for vitamin E supplementation, 1.12 (95% confidence…
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In polymorbid medical inpatients exclusively fed orally, documented or suspected micronutrient deficiencies should be repleted.
“In polymorbid medical inpatients exclusively fed orally, documented or suspected micronutrient deficiencies should be repleted.”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [96]
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- Authors
- Graat, J. M., Schouten, E. G., & Kok, F. J.
- Affiliations
- Wageningen University & Research (NL)
- ORCID
- Kok, Frans J.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2002-08-14
- Volume
- 288
- Issue
- 6
- Pages
- 715
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2132119356
- Cited by
- 230
- References
- 32
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 3 · 2018: 9 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 16
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- vitamin E supplementation, multivitamin-mineral supplementation, acute respiratory infections, older adults, micronutrient supplementation, infection incidence, infection severity, vitamin C, vitamin E, alpha-tocopherol, disease duration, fever, activity limitation, community-dwelling older adults, factorial trial, subgroup analysis
- MeSH terms
- Acute Disease, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Minerals, Respiratory Tract Infections, Severity of Illness Index, Vitamin E, Vitamins, Incidence, Treatment Failure, Dietary Supplements
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