Cited by 217Nutritional Studies and DietCardiovascular Health and Risk FactorsPhytochemicals and Antioxidant Activities

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Fruit and vegetable consumption and risk of cardiovascular disease: A meta-analysis of prospective cohort studies

Zhan, Jian, Liu, Yu-Jian, Cai, Long-Biao, Xu, Fang-Rong, Xie, Tao, He, Qi-Qiang·2017·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2015.1008980

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Abstract

A meta-analysis of prospective cohort studies was conducted to examine the relation between fruit and vegetables (FV) consumption and the risk of cardiovascular disease (CVD). We searched PubMed and EMBASE up to June 2014 for relevant studies. Pooled relative risks (RRs) were calculated and dose-response relationship was assessed. Thirty-eight studies, consisting of 47 independent cohorts, were eligible in this meta-analysis. There were 1,498,909 participants (44,013 CVD events) with a median follow-up of 10.5 years. The pooled RR (95% confidence interval) of CVD for the highest versus lowest category was 0.83 (0.79-0.86) for FV consumption, 0.84 (0.79-0.88) for fruit consumption, and 0.87 (0.83-0.91) for vegetable consumption, respectively. Dose-response analysis showed that those eating 800 g per day of FV consumption had the lowest risk of CVD. Our results indicate that increased FV intake is inversely associated with the risk of CVD. This meta-analysis provides strong support for the current recommendations to consume a high amount of FV to reduce CVD risk.

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Authors: Zhan, J., Liu, Y.-J., Cai, L.-B., Xu, F.-R., Xie, T., & He, Q.-Q.
Affiliations: Wuhan University (CN)
Corresponding author: He, Qi-Qiang
ORCID: Zhan, Jian
He, Qi-Qiang
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2015-06-26
Volume: 57
Issue: 8
Pages: 1650-1663
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2015.1008980
OpenAlex: W2149818158
Cited by: 217
References: 64
Citations by year: 2026: 6 · 2025: 17 · 2024: 19 · 2023: 19 · 2022: 26 · 2021: 25 · 2020: 28 · 2019: 37 · 2018: 21 · 2017: 13 · 2016: 5 · 2015: 1
FWCI: 1.92
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: fruit and vegetable intake, cardiovascular risk, fruit consumption, vegetable consumption, dose-response relationship, dietary recommendations, prospective cohort
MeSH terms: Cardiovascular Diseases, Fruit, Humans, Risk Factors, Vegetables, Databases, Factual

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Fruit and vegetable consumption and risk of cardiovascular disease: A meta-analysis of prospective cohort studies

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