The DOI matches its Crossref record, with a small difference in title or year; 103 of the 103 references it cites were found in a registry or an index.
Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Open accessAbstract
Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellular processes, such as cell cycle, apoptosis, autophagy, and biochemical metabolism, are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future. In addition, specific anthocyanin metabolites contributing to the observed in vivo biological activities, structure-activity relationships as well as additive and synergistic efficacy of anthocyanins are also discussed.
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“These molecules reduce oxidative stress, by lowering the number of free radicals.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [116]
Citations
Cites
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“…several excellent reviews have illustrated these natural dietary phytochemicals in terms of their absorption (McGhie and Walton, 2007), metabolism (He and Giusti, 2010), bioavailability (Fernandes et al., 2014), and pharmacokinetics (Kay, 2006) as well as their various analytical techniques…”
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“The relationship between anthocyanins intake and the reduced risk of developing cardiovascular disease has been indicated in several epidemiological studies (PrRimm et al., 1991; Wallace, 2011).”
BackgroundWu, X., Beecher, G. R., Holden, J. M., Haytowitz, D. B., Gebhardt, S. E., & Prior, R. L. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060300l · Cited by 1,190 · cited 1×
“Table 1 shows the daily consumption of anthocyanins from fruits, vegetables, and beverages obtained from the National Health and Nutrition Examination Survey (NHANES, 2001; Wu et al., 2006).”
BackgroundAnthocyanins and their role in cancer prevention
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“However, convincing epidemiological evidence indicating a positive association between the intake of anthocyanins-rich food and other cancers is needed to be further determined (Wang and Stoner, 2008).”
BackgroundFlavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women
Mink, P. J., Scrafford, C. G., Barraj, L. M., Harnack, L., Hong, C.-P., Nettleton, J. A., & Jacobs, D. R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.895 · Cited by 945 · cited 1×
“In addition, an Iowa Women’s Health Study with 34,489 women showed a significant reduction in cardiovascular disease mortality associated with anthocyanins-rich strawberry intake (Mink et al., 2007).”
BackgroundAnthocyanins in Fruits, Vegetables, and Grains
Mazza, G. A. (2018) · CRC Press eBooks · doi:10.1201/9781351069700 · Cited by 855 · cited 1×
“Anthocyanins belong to a large group of compounds, collectively known as flavonoids, which are a subgroup of an even larger group of compounds known as polyphenolics (Mazza and Miniati, 1993; Andersen, 2001; Andersen and Markham, 2006; McGhie and Walton, 2007).”
BackgroundAnthocyanins in fruits, vegetables and grains
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McGhie, T. K., & Walton, M. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700092 · Cited by 617 · cited 3×
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de Pascual‐Teresa, S., & Sánchez-Ballesta, M. T. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-007-9074-0 · Cited by 548 · cited 1×
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Cited by
Sorted by citations
Tena, N., Martı́n, J., & Asuero, A. G. (2020) · Antioxidants · doi:10.3390/antiox9050451 · Cited by 547
“In this sense, the type of aglycones, sugars, and acylated acids, and the position and degree of glycosylation and acylation seem to be the main factors influencing the anticancer property [191].”
Natural food pigments and colorants
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Natural Food Colorants and Preservatives: A Review, a Demand, and a Challenge
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Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects
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“Also, results from animal studies suggest that Cy3G may slow or inhibit the absorption of lipids and glucose in the intestine [15,100,121,122] confirming the postulated mechanisms in cells [1,118,119]) and the physiological impact in humans [113].”
BackgroundResultMediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288
Metadata
- Authors
- Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F.
- Affiliations
- Ministry of Education of the People's Republic of China (CN)
- University of Maryland, College Park (US)
- Corresponding author
- Chen, Fang
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-07-20
- Volume
- 57
- Issue
- 8
- Pages
- 1729-1741
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W1765735955
- Cited by
- 489
- References
- 103
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 69 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 63 · 2019: 45 · 2018: 33 · 2017: 19 · 2016: 8 · 2015: 3
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- anthocyanins, health benefits, molecular mechanisms, signaling pathways, mitogen-activated protein kinase, NF-κB, AMPK, Wnt/β-catenin signaling, apoptosis, autophagy, cell cycle, anthocyanin metabolites, structure-activity relationship, synergistic efficacy, disease prevention
- MeSH terms
- Anthocyanins, Anti-Inflammatory Agents, Antineoplastic Agents, Autophagy, Cardiovascular Diseases, Cell Cycle, Humans, Hypoglycemic Agents, Signal Transduction, Apoptosis, Neuroprotective Agents, Anti-Obesity Agents
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