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Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Open accessAbstract
Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellular processes, such as cell cycle, apoptosis, autophagy, and biochemical metabolism, are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future. In addition, specific anthocyanin metabolites contributing to the observed in vivo biological activities, structure-activity relationships as well as additive and synergistic efficacy of anthocyanins are also discussed.
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“These molecules reduce oxidative stress, by lowering the number of free radicals.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [116]
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“The black, dark violet and red color fruits are widely recognized as a valuable source of anthocyanins, one of the most widespread families of natural pigments in the plant kingdom and are, therefore used as a safe and natural food colorant with pro-health properties [6,10].”
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Karasawa, M. M. G., & Mohan, C. (2018) · Natural Products and Bioprospecting · doi:10.1007/s13659-018-0186-6 · Cited by 203
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“Also, it had beneficial metabolic effects by improving dyslipidemia, increasing antioxidant capacity and preventing insulin resistance in subjects with type 2 diabetes (Li et al. 2015b).”
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Mark, R., Lyu, X., Lee, J. J. L., Parra‐Saldívar, R., & Chen, W. N. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.008 · Cited by 134
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Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
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“[39], anthocyanins ameliorate oxidative stress by lowering free radical production and lipid peroxidation.”
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“Anthocyanins are natural pigments that provide red, purple, or blue colors to several plant elements, acting as an important regulator of plant stability and quality in different environmental conditions [9,30].”
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“The interest to deepen the knowledge of the health benefits of anthocyanins has also strongly increased thanks to their anticancer, anti-inflammatory, antidiabetic, and neuroprotective activities together with prevention of cardiovascular diseases [47].”
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“These results showed phospholipid complex enhances the in vivo bioavailability of black rice anthocyanins (Wang, Lv, Zhao, & Li, 2017).”
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Grant, W. B., & Blake, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230418 · Cited by 82
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Background
Metadata
- Authors
- Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F.
- Affiliations
- Ministry of Education of the People's Republic of China (CN)
- University of Maryland, College Park (US)
- Corresponding author
- Chen, Fang
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-07-20
- Volume
- 57
- Issue
- 8
- Pages
- 1729-1741
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W1765735955
- Cited by
- 489
- References
- 103
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 69 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 63 · 2019: 45 · 2018: 33 · 2017: 19 · 2016: 8 · 2015: 3
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- anthocyanins, health benefits, molecular mechanisms, signaling pathways, mitogen-activated protein kinase, NF-κB, AMPK, Wnt/β-catenin signaling, apoptosis, autophagy, cell cycle, anthocyanin metabolites, structure-activity relationship, synergistic efficacy, disease prevention
- MeSH terms
- Anthocyanins, Anti-Inflammatory Agents, Antineoplastic Agents, Autophagy, Cardiovascular Diseases, Cell Cycle, Humans, Hypoglycemic Agents, Signal Transduction, Apoptosis, Neuroprotective Agents, Anti-Obesity Agents
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