The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Ironing out siderophore biosynthesis: a review of non-ribosomal peptide synthetase (NRPS)-independent siderophore synthetases
Abstract
Iron is required for microbial growth and proliferation. To survive in low-iron environments, some microorganisms secrete ferric iron chelators called siderophores. Siderophore biosynthesis occurs via two pathways: the non-ribosomal peptide synthetase (NRPS) pathway and the NRPS-independent siderophore (NIS) synthetase pathway. NIS enzymes function by adenylating a carboxylic acid substrate, typically citrate, or a derivative, followed by nucleophilic capture of an amine or alcohol and displacement of a citryl intermediate. In this review, we summarize recent advances in NIS biochemistry with a particular focus on structural biology and confirm the classification of NIS enzymes into Types A, A', B, and C based on substrate specificity. Based on a phylogenetic analysis, we also propose a new subclass of NIS enzymes, Type C', responsible for dimerization and macrocyclization of complex and substituted amine or amide intermediates. Finally, we describe the role of NIS enzymes in virulence of pathogenic microbes and discuss NIS inhibitors as potential anti-microbial agents.
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The Phyre2 web portal for protein modeling, prediction and analysis
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“Because K. pneumoniae secretes yersiniabactin, salmochelin, and enterobactin, Russo et al. (2015) created gene knockout strains for each siderophore (DentB was deficient in enterobactin and salmochelin, Dirp2 was deficient in yersiniabactin and DentBirp2 was deficient for yersiniabactin,…”
BackgroundMicrobial siderophore-mediated transport.
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Bacterial siderophores in community and host interactions
Kramer, J., Özkaya, Ö., & Kümmerli, R. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0284-4 · Cited by 998
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Garber, A. I., Nealson, K. H., Okamoto, A., McAllister, S. M., Chan, C. S., Barco, R. A., & Merino, N. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00037 · Cited by 437
Biocontrol of Postharvest Fruit Fungal Diseases by Bacterial Antagonists: A Review
Carmona-Hernandez, S., Reyes-Pérez, J., Chiquito-Contreras, R., Rincon-Enriquez, G., Cerdan-Cabrera, C., & Hernandez-Montiel, L. (2019) · Agronomy · doi:10.3390/agronomy9030121 · Cited by 282
Expanding the Substrate Selectivity of the Fimsbactin Biosynthetic Adenylation Domain, FbsH
Ahmed, S. F., Balutowski, A., Yang, J., Wencewicz, T. A., & Gulick, A. M. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00512 · Cited by 8
Metadata
- Authors
- Carroll, C. S., & Moore, M. M.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2018-06-04
- Volume
- 53
- Issue
- 4
- Pages
- 356-381
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- OpenAlex
- W2806179485
- Cited by
- 168
- References
- 19
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carroll, C. S., & Moore, M. M. (2018). Ironing out siderophore biosynthesis: a review of non-ribosomal peptide synthetase (NRPS)-independent siderophore synthetases. Critical Reviews in Biochemistry and Molecular Biology. https://doi.org/10.1080/10409238.2018.1476449
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