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The Concordance Correlation Coefficient for Repeated Measures Estimated by Variance Components
Abstract
The concordance correlation coefficient (CCC) is an index that is commonly used to assess the degree of agreement between observers on measuring a continuous characteristic. Here, a CCC for longitudinal repeated measurements is developed through the appropriate specification of the intraclass correlation coefficient from a variance components linear mixed model. A case example and the results of a simulation study are provided.
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“If available, test-retest data are also extremely helpful, as they can help prioritize features on the basis of their reproducibility (51,52).”
From Radiomics: Images Are More than Pictures, They Are Data (2016) · cites this paper as [52]
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Metadata
- Authors
- Carrasco, J. L., King, T. S., & Chinchilli, V. M.
- Affiliations
- Universitat de Barcelona (ES)
- Pennsylvania State University (US)
- Corresponding author
- Carrasco, Josep L.
- Venue
- Journal of Biopharmaceutical Statistics
- Publisher
- Informa UK Limited
- Published
- 2009-01-02
- Volume
- 19
- Issue
- 1
- Pages
- 90-105
- ISSN
- 1054-3406 (ISSN-L)
- 1520-5711
- OpenAlex
- W2149541891
- Cited by
- 111
- References
- 13
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 8 · 2023: 3 · 2022: 14 · 2021: 10 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 11 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biopharmaceutical Statistics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Bayesian Inference
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- concordance correlation coefficient, repeated measures, intraclass correlation coefficient, variance components, linear mixed models, interobserver agreement, longitudinal data, measurement agreement
- MeSH terms
- Algorithms, Analysis of Variance, Computer Simulation, Pharmaceutical Preparations, Humans, Hydrocortisone, Pharmacokinetics, Models, Statistical, Observer Variation, Confidence Intervals, Linear Models, Area Under Curve
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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