Cited by 108Opioid Use Disorder TreatmentSubstance Abuse Treatment and OutcomesPain Management and Opioid Use

Pharmacotherapy in the Treatment of Addiction: Methadone

Open access
Kreek, Mary Jeanne, Borg, Lisa, Ducat, Elizabeth, Ray, Brenda·2010·Journal of Addictive Diseases

Abstract

Methadone maintenance treatment (MMT) is the most widely available pharmacotherapy for opioid addiction and has been shown to be an effective and safe treatment over a period of 40 years. Although women comprise approximately 40% of clients currently being treated in MMT programs, comparatively little research geared specifically toward this group has been published. This article begins with an overview of neurobiological studies on opioid addiction, including a discussion of gender differences, followed by a review of the pharmacology of methadone. The authors then examine the particular needs and differences of women being treated in MMTs, including co-dependence with other substances, women's health issues, and psychosocial needs unique to this population. Research shows that women have different substance abuse treatment needs in comparison to their male counterparts. One New York City MMT program that has attempted to address these differences is highlighted.

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Research works printed but not linked: 2

  1. [5]Kreek MJ The role of qualitative and quantitative analysis of drugs and their metabolites in maternal-neonatal studies National Institute on Drug Abuse Symposium on Comprehensive Health Care for Addicted Families and Their Children 1977 Washington, DC Services Research Report (USGPO) 67 73 #017-024-00598-3
  2. [75]Kleinschmidt KC Wainscott M Ford MD Ford MD Delaney KA Ling LJ Erickson T Opioids Ford: clinical toxicology 2001 1st Ed. Philadelphia WB Saunders 627 639

Authors
Kreek, M. J., Borg, L., Ducat, E., & Ray, B.
Affiliations
Rockefeller University (US)
Venue
Journal of Addictive Diseases
Published
2010-04-16
Volume
29
Issue
2
Pages
200-216
ISSN
  • 1055-0887 (ISSN-L)
  • 1545-0848
OpenAlex
W2103431332
Cited by
108
References
155
Citations by year
2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 12 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 6 · 2012: 8
FWCI
7.00
Type
journal article
Language
en
Open access
Locations
  • Journal of Addictive Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH79880, R01MH079880)
  • National Institute on Drug Abuse (P50DA005130, P60 DA 05130, P60DA005130)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
methadone maintenance treatment, opioid use disorder, women, gender differences, opioid pharmacology, codependency, women's health, psychosocial needs, addiction treatment
MeSH terms
Analgesics, Opioid, Attitude to Health, Female, Heroin Dependence, Humans, Methadone, Surveys and Questionnaires, Behavior, Addictive, Treatment Outcome

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