Cited by 213Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryRadiopharmaceutical Chemistry and Applications

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Lymphatic Uptake of Pulmonary Delivered Radiolabelled Solid Lipid Nanoparticles

Videira, Mafalda A., Botelho, M.F., Santos, Ana C., Gouveia, Luis F., Pedroso de Lima, J.J., Almeida, António J.·2002·Journal of Drug Targeting

DOI 10.1080/1061186021000054933

Open this paper in CoChat — free account

Abstract

UNLABELLED: Lymphatic drainage plays an important role in the uptake of particulates in the respiratory system, being also associated to the spreading of lung cancer through metastasis development. In recent years solid lipid nanoparticles (SLN) have been proposed as carriers of anti-tumoural drugs, for their low toxicity and surface characteristics make them suitable for either imaging (gamma-scintigraphy) or therapy upon encapsulation of cytotoxic drugs. Assessment of inhaled radiolabelled SLN biodistribution is described in the present work. METHODS: Nanoparticles (200 nm) were radiolabelled with 99mTc using the lipophilic chelator D,L-hexamehylpropyleneamine oxime (HMPAO). Biodistribution studies were carried out following aerosolisation and administration of a 99mTc-HMPAO-SLN suspension to a group of adult male Wistar rats. A 60 min dynamic image acquisition was performed in a gamma-camera, followed by static image collection at 30 min intervals up to 4 h postinhalation. Radiation counting was performed in organ samples, collected after the animals were sacrificed. RESULTS: The data show an important and significant uptake of the radiolabelled SLN into the lymphatics after inhalation, and a high rate of distribution in periaortic, axillar and inguinal lymph nodes. CONCLUSION: Results indicate that SLN could be effective colloidal carriers for lymphoscintigraphy or therapy upon pulmonary delivery.

Integrity signals

Registry

Crossref · 10.1080/1061186021000054933

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Solid lipid nanoparticles Production, characterization and applications
Mehnert, W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00105-3 · Cited by 3,158
The Lung: Scientific Foundations
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-6-503_2 · Cited by 1,183
Microsatellite alterations in plasma DNA of small cell lung cancer patients
Chen, X. Q., Stroun, M., Magnenat, J.-L., Nicod, L. P., Kurt, A.-M., Lyautey, J., Lederrey, C., & Anker, P. (1996) · Nature Medicine · doi:10.1038/nm0996-1033 · Cited by 647
The Role of Macrophages in Particle Translocation from Lungs to Lymph Nodes
Harmsen, A. G., Muggenburg, B. A., Snipes, M. B., & Bice, D. E. (1985) · Science · doi:10.1126/science.4071052 · Cited by 326
Lymphatic targeting with nanoparticulate system
Nishioka, Y., & Yoshino, H. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00121-6 · Cited by 221
Solid Lipid Nanoparticles in Lymph and Plasma After Duodenal Administration to Rats
Bargoni, A., Cavalli, R., Caputo, O., Fundaro', A., Gasco, M. R., & Zara, G. P. (1998) · Pharmaceutical Research · doi:10.1023/a:1011975120776 · Cited by 148
Controlled delivery of an antitumor drug: localized action of liposome encapsulated cytosine arabinoside administered via the respiratory system.
Juliano, R. L., & McCullough, H. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32184-1 · Cited by 87
Novel Taxol formulation: polyvinylpyrrolidone nanoparticle-encapsulated Taxol for drug delivery in cancer therapy.
Sharma, D., Chelvi, T. P., Kaur, J., Chakravorty, K., De, T., Maitra, A. N., & Ralhan, R. (1996) · PubMed · Cited by 85
The migration of bronchoalveolar macrophages into hilar lymph nodes.
Corry, D. B., Kulkarni, P. V., & Lipscomb, M. F. (1984) · PubMed · Cited by 79
Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in Rats
Maincent, P., Thouvénot, P., Amicabile, C., Hoffman, M., Kreuter, J., Couvreur, P., & Devissaguet, J. P. (1992) · Pharmaceutical Research · doi:10.1023/a:1015895804597 · Cited by 76

Show all 25 references

Sorted by citations

“Nanoantibiotics”: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era
Huh, A. J., & Kwon, Y. J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.002 · Cited by 1,920
Biocompatibility of Gold Nanoparticles and Their Endocytotic Fate Inside the Cellular Compartment: A Microscopic Overview
Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M. (2005) · Langmuir · doi:10.1021/la0513712 · Cited by 1,689
Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles
Kirchner, C., Liedl, T., Kudera, S., Pellegrino, T., Muñoz Javier, A., Gaub, H. E., Stölzle, S., Fertig, N., & Parak, W. J. (2005) · Nano Letters · doi:10.1021/nl047996m · Cited by 1,619
Structural Design Principles for Delivery of Bioactive Components in Nutraceuticals and Functional Foods
McClements, D. J., Decker, E. A., Park, Y., & Weiß, J. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390902841529 · Cited by 949
Development of Nanoparticles for Antimicrobial Drug Delivery
Zhang, L., Pornpattananangkul, D., Hu, C.-M., & Huang, C.-W. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790416290 · Cited by 904
Solid lipid nanoparticles as a drug delivery system for peptides and proteins☆
Almeida, A. J., & Souto, E. B. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.007 · Cited by 817
Self-citation
Nanostructured lipid carriers: Promising drug delivery systems for future clinics
Beloqui, A., Solinís, M. Á., Rodríguez‐Gascón, A., Almeida, A. J., & Véronique Préat, A. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.09.004 · Cited by 790
Self-citation
Inhaled nanoparticles—A current review
Yang, W. P., Peters, J. I., & Williams, R. O. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.02.011 · Cited by 697
From Sewer to Saviour—Targeting the Lymphatic System to Promote Drug Exposure and Activity
Trevaskis, N. L., Kaminskas, L. M., & Porter, C. J. H. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4608 · Cited by 654
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645
Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for pulmonary application: A review of the state of the art
Weber, S., Zimmer, A., & Pardeike, J. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.08.013 · Cited by 579
Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives.
Üner, M., & Yener, G. (2007) · PubMed Central · Cited by 536
Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
Balasubramanian, S. K., Jittiwat, J., Manikandan, J., Ong, C. N., Yu, L. E., & Ong, W. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.079 · Cited by 538
Nanomedicine in pulmonary delivery
Mansour, H. M., Haemosu, & Wu, X. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s4937 · Cited by 497
Solid Lipid Nanoparticles as Delivery Systems for Bioactive Food Components
Weiß, J., Decker, E. A., McClements, D. J., Kristbergsson, K., Helgason, T., & Awad, T. S. (2008) · Food Biophysics · doi:10.1007/s11483-008-9065-8 · Cited by 474
Targeted delivery of nanoparticles for the treatment of lung diseases
Azarmi, S., Roa, W. H., & Löbenberg, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.006 · Cited by 440
Lipid nanoparticles for parenteral delivery of actives
Joshi, M. D., & Müller, R. H. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.003 · Cited by 435
Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery
Battaglia, L., & Gallarate, M. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.673278 · Cited by 400
Physiologically Based Pharmacokinetic Modeling of Nanoparticles
Li, M., Al‐Jamal, K. T., Kostarelos, K., & Reineke, J. (2010) · ACS Nano · doi:10.1021/nn1018818 · Cited by 358
Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN)
Helgason, T., Awad, T. S., Kristbergsson, K., McClements, D. J., & Weiss, J. (2009) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2009.03.012 · Cited by 341
Advanced drug delivery to the lymphatic system: lipid-based nanoformulations
Darwis, Y., Khan, A. A., Mudassir, J., & Mohtar, N. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s41521 · Cited by 341
Solid lipid particle-based inhalable sustained drug delivery system against experimental tuberculosis
Pandey, R., & Khuller, G. K. (2005) · Tuberculosis · doi:10.1016/j.tube.2004.11.003 · Cited by 318
Lipid-Based Nanoparticles for Drug Delivery Systems
Samimi, S., Maghsoudnia, N., Eftekhari, R. B., & Dorkoosh, F. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814031-4.00003-9 · Cited by 295
Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer
Hamoudeh, M., Kamleh, M. A., Diab, R., & Fessi, H. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.04.013 · Cited by 282
Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles
Cai, S., Yang, Q., Bagby, T. R., & Forrest, M. L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.05.017 · Cited by 255
Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers
Patlolla, R. R., Chougule, M. B., Patel, A. R., Jackson, T., Tata, P. N. V., & Singh, M. S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.006 · Cited by 250
Solid lipid nanoparticles for pulmonary delivery of insulin
Liu, J., Gong, T., Fu, H., Wang, C., Wang, X., Chen, Q., Zhang, Q., He, Q., & Zhang, Z. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.01.008 · Cited by 249
Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery
Souto, E. B., Fangueiro, J. F., Fernandes, A. R., Cano, A. C., Sánchez‐López, E., García, M. L., Severino, P. B., Paganelli, M. O., Chaud, M. V., & Silva, A. M. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e08938 · Cited by 267
Development of an Itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application
Pardeike, J., Weber, S., Haber, T., Wagner, J., Zarfl, H. P., Plank, H., & Zimmer, A. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.07.040 · Cited by 216
Lipid Nanoparticles: Effect on Bioavailability and Pharmacokinetic Changes
Souto, E. B., & Müller, R. H. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00477-3_4 · Cited by 217
Formation, characterization, and fate of inhaled drug nanoparticles
Zhang, J., Wu, L., Chan, H., & Watanabe, W. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.11.002 · Cited by 213
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
Silva, C. O., Pinho, J. O., Lopes, J., Almeida, A. J., Gaspar, M. M., & Reis, C. P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11010022 · Cited by 215
Self-citation
Recent Trends of the Bio-Inspired Nanoparticles in Cancer Theranostics
Madamsetty, V. S., Mukherjee, A., & Mukherjee, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01264 · Cited by 211
Nanostructured Encapsulation Systems
Weiß, J., Gaysinsky, S., Davidson, M., & McClements, J. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374124-0.00024-7 · Cited by 201
Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles
Yaghmur, A., & Mu, H. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.02.013 · Cited by 198
Toxico-/biokinetics of nanomaterials
Landsiedel, R., Fabian, E. J., Ma‐Hock, L., Wohlleben, W., Wiench, K., Oesch, F., & van Ravenzwaay, B. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0858-7 · Cited by 200
Antitubercular inhaled therapy: opportunities, progress and challenges
Pandey, R., & Khuller, G. K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki027 · Cited by 188
Nanotechnology-based inhalation treatments for lung cancer: state of the art
Akhter, S., Ahmad, J., Rizwanullah, M., Rahman, M., Ahmad, M. Z., Rizvi, M. M. A., Ahmad, F. J., Amin, S., & Kamal, M. A. (2015) · Nanotechnology Science and Applications · doi:10.2147/nsa.s49052 · Cited by 180
ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier
Magro, R. D., Ornaghi, F., Cambianica, I., Beretta, S., Re, F., Musicanti, C., Rigolio, R., Donzelli, E., Canta, A., Ballarini, E., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.039 · Cited by 168
Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation
Chattopadhyay, S., Chen, J.-Y., Chen, H., & Hu, C. J. (2017) · Nanotheranostics · doi:10.7150/ntno.19796 · Cited by 171
Nanomedicine: Novel approaches in human and veterinary therapeutics
Irache, J. M., Esparza, I., Gamazo, C., Agüeros, M., & Espuelas, S. (2011) · Veterinary Parasitology · doi:10.1016/j.vetpar.2011.05.028 · Cited by 154
Microparticles containing erlotinib-loaded solid lipid nanoparticles for treatment of non-small cell lung cancer
Bakhtiary, Z., Barar, J., Aghanejad, A., Saei, A. A., Nemati, E., Ezzati, A., & Omidi, Y. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1310223 · Cited by 139
Formulation Design of Dry Powders for Inhalation
Weers, J. G., & Miller, D. P. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24574 · Cited by 142
Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route
Lauterbach, A., & Müller-Goymann, C. C. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.06.020 · Cited by 133
Preclinical evaluation of a pulmonary delivered paclitaxel-loaded lipid nanocarrier antitumor effect
Videira, M., Almeida, A. J., & Fabra, À. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.12.007 · Cited by 128
Self-citation
Lipid-Based Nanoparticles for Drug-Delivery Systems
Kumar, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814033-8.00008-4 · Cited by 128
The formulation of nanomedicines for treating tuberculosis
Costa, A., Pinheiro, M., Magalhães, J., Ribeiro, R., Seabra, V., Reis, S., & Sarmento, B. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.012 · Cited by 123
Lipid-based carriers for pulmonary products: Preclinical development and case studies in humans
Cipolla, D. C., Shekunov, B. Y., Blanchard, J., & Hickey, A. J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.001 · Cited by 123
Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery
Shen, A. M., & Minko, T. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.011 · Cited by 124
Solid Lipid Nanoparticles: Applications and Prospects in Cancer Treatment
Sivadasan, D., Ramakrishnan, K., Mahendran, J., Ranganathan, H., Karuppaiah, A., & Rahman, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076199 · Cited by 117
The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects
Rogueda, P., & Traini, D. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.6.595 · Cited by 113
Biodistribution of Amikacin Solid Lipid Nanoparticles after Pulmonary Delivery
Varshosaz, J., Ghaffari, S., Mirshojaei, S. F., Jafarian‐Dehkordi, A., Atyabi, F., Kobarfard, F., & Azarmi, S. (2013) · BioMed Research International · doi:10.1155/2013/136859 · Cited by 110
In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model
Wong, H. L., Rauth, A. M., Bendayan, R., & Wu, X. Y. (2006) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.10.022 · Cited by 109
The function and performance of aqueous aerosol devices for inhalation therapy
Carvalho, T. C., & McConville, J. T. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12541 · Cited by 108
Influence of Polymorphic Transformations on Gelation of Tripalmitin Solid Lipid Nanoparticle Suspensions
Helgason, T., Awad, T. S., Kristbergsson, K., McClements, D. J., & Weiss, J. (2008) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-008-1219-9 · Cited by 105
In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery
Woods, A., Patel, A., Spina, D., Riffo‐Vasquez, Y., Morgan, A. B., de Rosales, R. T. M., Sunassee, K., Clark, S. K., Collins, H., Bruce, K., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.05.269 · Cited by 105
Inhaled nanoparticles–An updated review
Praphawatvet, T., Peters, J. I., & Williams, R. O. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119671 · Cited by 105
Administration strategies for proteins and peptides
Ibraheem, D., Elaı̈ssari, A., & Fessi, H. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.10.059 · Cited by 101
Absorption, Disposition and Pharmacokinetics of Solid Lipid Nanoparticles
Qi, J., Lü, Y., & Wu, W. (2012) · Current Drug Metabolism · doi:10.2174/138920012800166526 · Cited by 98
Low cytotoxicity of solid lipid nanoparticles inin vitroandex vivolung models
Nassimi, M., Schleh, C., Lauenstein, H.-D., Hussein, R., Lübbers, K., Pohlmann, G., Switalla, S., Sewald, K., Müller, M., Krug, N., et al. (2009) · Inhalation Toxicology · doi:10.1080/08958370903005769 · Cited by 97
Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses
Forbes, B., O’Lone, R. B., Pribul, P. K., Cahn, A. P., Clarke, C. J., Collinge, M., Dailey, L. A., Donnelly, L., Dybowski, J. A., Hassall, D. G., et al. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.001 · Cited by 97
Transforming Nuclear Medicine with Nanoradiopharmaceuticals
Roy, I., Krishnan, S., Kabashin, A. V., Zavestovskaya, I. N., & Prasad, P. N. (2022) · ACS Nano · doi:10.1021/acsnano.1c10550 · Cited by 96
Solid Lipid Nanoparticle Formulations: Pharmacokinetic and Biopharmaceutical Aspects in Drug Delivery
Souto, E. B., & Doktorovová, S. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(09)64006-4 · Cited by 94
Lymphatic system: a prospective area for advanced targeting of particulate drug carriers
Singh, I., Swami, R., Khan, W., & Sistla, R. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.866088 · Cited by 81
Lipid-based carriers: manufacturing and applications for pulmonary route
Jaafar‐Maalej, C., Elaı̈ssari, A., & Fessi, H. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.702751 · Cited by 77
Chitosan-coated Nanoparticles Enhanced Lung Pharmacokinetic Profile of Voriconazole Upon Pulmonary Delivery in Mice
Paul, P., Sengupta, S., Mukherjee, B., Shaw, T. K., Gaonkar, R. H., & Debnath, M. C. (2018) · Nanomedicine · doi:10.2217/nnm-2017-0291 · Cited by 76
Nanocarriers for Pulmonary Administration of Peptides and Therapeutic Proteins
Andrade, F., Videira, M., Ferreira, D., & Sarmento, B. F. C. C. (2010) · Nanomedicine · doi:10.2217/nnm.10.143 · Cited by 76
Self-citation
Drug Delivery Systems
Paolino, D., Sinha, P. M., Fresta, M., & Mauro Ferrari, B. (2006) · Encyclopedia of Medical Devices and Instrumentation · doi:10.1002/0471732877.emd274 · Cited by 73
Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update
Abdulbaqi, I. M., Assi, R. A., Yaghmur, A., Darwis, Y., Mohtar, N., Parumasivam, T., Saqallah, F. G., & Wahab, H. A. (2021) · Pharmaceuticals · doi:10.3390/ph14080725 · Cited by 71
Docetaxel‐loaded solid lipid nanoparticles: a novel drug delivery system
Sumera, S., Anwar, A., Ovais, M., Khan, A., & Raza, A. (2017) · IET Nanobiotechnology · doi:10.1049/iet-nbt.2017.0001 · Cited by 68
Recent trends in the use of lipidic nanoparticles as pharmaceutical carriers for cancer therapy and diagnostics
Mussi, S. V., & Torchilin, V. P. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20990c · Cited by 67
Preclinical Lymphatic Imaging
Zhang, F., Niu, G., Lu, G., & Chen, X. S. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0421-y · Cited by 65
Passive lung-targeted drug delivery systems via intravenous administration
Wei, Y., & Zhao, L. (2013) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2012.757782 · Cited by 66
Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
Tan, S. L. J., & Billa, N. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111817 · Cited by 70
Stabilization of food dispersions by enzymes
Zeeb, B., Fischer, L., & Weiß, J. (2013) · Food & Function · doi:10.1039/c3fo60499c · Cited by 61
Solid lipid nanoparticles for drug delivery
Harms, M., & Müller-Goymann, C. C. (2011) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(11)50008-5 · Cited by 61
A comparison of the lung clearance kinetics of solid lipid nanoparticles and liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats
Haque, S., Whittaker, M. R., McIntosh, M. P., Pouton, C. W., Phipps, S., & Kaminskas, L. M. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.01.001 · Cited by 58
The nanoscale in pulmonary delivery. Part 2: formulation platforms
Rogueda, P., & Traini, D. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.6.607 · Cited by 57
The impact of pulmonary diseases on the fate of inhaled medicines—A review
Wang, Y.-B., Watts, A. B., Peters, J. I., & Williams, R. O. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.042 · Cited by 56
Lymphatic immunomodulation using engineered drug delivery systems for cancer immunotherapy
Manspeaker, M. P., & Thomas, S. N. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.10.004 · Cited by 51
Lymphatic uptake of lipid nanoparticles following endotracheal administration
Videira, M., Gano, L., dos Santos, C. P., Neves, M., & Almeida, A. J. (2006) · Journal of Microencapsulation · doi:10.1080/02652040600788221 · Cited by 49
Self-citation
Nanoparticles Targeting Lymph Nodes for Cancer Immunotherapy: Strategies and Influencing Factors
Li, Z., Zhong, N., Cao, L., Cai, Z., Xiao, Y., Wang, G.-R., Liu, B., Xu, C., & Bu, L. (2024) · Small · doi:10.1002/smll.202308731 · Cited by 48
Secondary cytotoxicity mediated by alveolar macrophages: A contribution to the total efficacy of nanoparticles in lung cancer therapy?
Alhallak, K., Azarmi, S., Anwar‐Mohamed, A., Roa, W., & Löbenberg, R. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.05.002 · Cited by 45
Antimicrobials
Das, B., & Patra, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46152-8.00001-9 · Cited by 43
Pulmonary targeting potential of rosuvastatin loaded nanostructured lipid carrier: Optimization by factorial design
Patil-Gadhe, A., & Pokharkar, V. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.080 · Cited by 44
Lipid nanoparticulate systems
Rawal, S. U., & Patel, M. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813687-4.00002-5 · Cited by 42
Iodinated NanoClusters as an Inhaled Computed Tomography Contrast Agent for Lung Visualization
Aillon, K. L., El-Gendy, N. A., Dennis, C., Norenberg, J. P., McDonald, J. D., & Berkland, C. J. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1000718 · Cited by 40
Physicochemical Characteristics and In Vitro Toxicity/Anti-SARS-CoV-2 Activity of Favipiravir Solid Lipid Nanoparticles (SLNs)
Tulbah, A. S., & Lee, W. (2021) · Pharmaceuticals · doi:10.3390/ph14101059 · Cited by 41
Lipid nanocarriers
Shukla, T., Upmanyu, N., Pandey, S. P., & Gosh, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813687-4.00001-3 · Cited by 38
Acoustic cavitation assisted hot melt mixing technique for solid lipid nanoparticles formulation, characterization, and controlled delivery of poorly water soluble drugs
Kumar, R., Singh, A. K., & Garg, N. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101277 · Cited by 37
Innovations in lymph node targeting nanocarriers
Kim, J., Archer, P. A., & Thomas, S. N. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101534 · Cited by 39
Chloramphenicol-incorporated poly lactide-co-glycolide (PLGA) nanoparticles: Formulation, characterization, technetium-99m labeling and biodistribution studies
Halder, K. K., Mandal, B., Debnath, M. C., Bera, H., Ghosh, L. K., & Gupta, B. K. (2008) · Journal of drug targeting · doi:10.1080/10611860801899300 · Cited by 36
Poly(vinyl alcohol) nanoparticle stability in biological media and uptake in respiratory epithelial cell layers in vitro
Mádlová, M., Jones, S. A., Zwerschke, I., Ma, Y., Hider, R. C., & Forbes, B. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.01.009 · Cited by 36
ChemInform Abstract: Solid Lipid Nanoparticles: Colloidal Carrier Systems for Drug Delivery
Swathi, G., Prasanthi, N. L., Manikiran, S. S., & Ramarao, N. (2011) · ChemInform · doi:10.1002/chin.201202274 · Cited by 35
The lymphatic vasculature in lung function and respiratory disease
Trivedi, A., & Reed, H. O. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1118583 · Cited by 34
Therapeutic nanostructures for pulmonary drug delivery
Javadzadeh, Y., & Yaqoubi, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46143-6.00020-8 · Cited by 37
89 Zr-Labeled Anti-Endoglin Antibody-Targeted Gold Nanoparticles for Imaging Cancer: Implications for Future Cancer Therapy
Karmani, L., Bouchat, V., Bouzin, C., Levêque, P., Labar, D., Bol, A., Deumer, G., Marega, R., Bonifazi, D., Haufroid, V., et al. (2014) · Nanomedicine · doi:10.2217/nnm.13.185 · Cited by 34
Solid lipid nanoparticles of diethylcarbamazine citrate for enhanced delivery to the lymphatics:in vitroandin vivoevaluation
Siram, K., Raghavan, C. V., Natarajan, T., Balakumar, K., Ebrahim, H. R. M., Karanam, V., Muthuswamy, S. S. K., & Ranganathan, H. P. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.915310 · Cited by 33
Evaluation of radiolabeled curcumin-loaded solid lipid nanoparticles usage as an imaging agent in liver-spleen scintigraphy
Ayan, A. K., Yenilmez, A., & Eroğlu, H. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.02.114 · Cited by 33
Pulmonary Drug Delivery: Novel Pharmaceutical Technologies Breathe New Life into the Lungs
Nanjwade, B. K., Adichwal, S. A., Gaikwad, K. R., Parikh, K. A., & Manvi, F. V. (2011) · PDA Journal of Pharmaceutical Science and Technology · doi:10.5731/pdajpst.2011.00704 · Cited by 32

Authors: Videira, M. A., Botelho, M. F., Santos, A. C., Gouveia, L. F., Pedroso de Lima, J. J., & Almeida, A. J.
Affiliations: University of Lisbon (PT)
University of Coimbra (PT)
ORCID: Videira, Mafalda A.
Botelho, M.F.
Santos, Ana C.
Almeida, António J.
Venue: Journal of Drug Targeting
Publisher: Informa UK Limited
Published: 2002-01
Volume: 10
Issue: 8
Pages: 607-613
ISSN: 1026-7158 (ISSN-L)
1061-186X
1029-2330
DOI: 10.1080/1061186021000054933
OpenAlex: W2115533786
Cited by: 213
References: 25
Citations by year: 2026: 1 · 2025: 1 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 12 · 2013: 14 · 2012: 14
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Locations: Journal of drug targeting (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Funders: Fundação para a Ciência e a Tecnologia
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
Keywords: solid lipid nanoparticles, lymphatic absorption, pulmonary drug delivery, aerosol inhalation, 99mTc-HMPAO, tissue distribution, lymphoscintigraphy, lymph node distribution, lung cancer metastasis, scintigraphy, nanoparticle drug carriers
MeSH terms: Administration, Inhalation, Animals, Colloids, Drug Carriers, Image Processing, Computer-Assisted, Isotope Labeling, Lipids, Lung, Lymphatic System, Male, Microspheres, Spirometry, Tissue Distribution, Rats, Wistar, Radiopharmaceuticals, Technetium Tc 99m Exametazime, Rats, Lymphoscintigraphy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lymphatic Uptake of Pulmonary Delivered Radiolabelled Solid Lipid Nanoparticles

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks