The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin
Abstract
The position of conjugation of the flavonoid quercetin dramatically affects biological activity in vitro, therefore it is important to determine the exact nature of the plasma metabolites. In the present study, we have used various methods (HPLC with diode array detection, LCMS, chemical and enzymic synthesis of authentic conjugates and specific enzymic hydrolysis) to show that quercetin glucosides are not present in plasma of human subjects 1.5 h after consumption of onions (a rich source of flavonoid glucosides). All four individuals had similar qualitative profiles of metabolites. The major circulating compounds in the plasma after 1.5 h are identified as quercetin-3-glucuronide, 3'-methylquercetin-3-glucuronide and quercetin-3'-sulfate. The existence of substitutions in the B and/or C ring of plasma quercetin metabolites suggests that these conjugates will each have very different biological activities.
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Citations
Cites
Pharmacokinetics and bioavailability of quercetin glycosides in humans
Graefe, E. U., Wittig, J., Mueller, S., Riethling, A., Uehleke, B., Drewelow, B., Pforte, H., Jacobasch, G., Derendorf, H., & Veit, M. (2001) · The Journal of Clinical Pharmacology · doi:10.1177/00912700122010366 · Cited by 649
Cited by
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Bioavailability of the polyphenols: Status and controversies
D’Archivio, M., Filesi, C., Varì, R., Scazzocchio, B., & Masella, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041321 · Cited by 950
A review: using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals
Li, Z., Jiang, H., Xu, C., & Gu, L. (2015) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2014.05.010 · Cited by 376
Metadata
- Authors
- Day, A. J., Mellon, F., Barron, D., Sarrazin, G., Morgan, M. R. A., & Williamson, G.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 35
- Issue
- 6
- Pages
- 941-952
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2168918080
- Cited by
- 472
- References
- 1
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Day, A. J., Mellon, F., Barron, D., Sarrazin, G., Morgan, M. R. A., & Williamson, G. (2001). Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin. Free Radical Research. https://doi.org/10.1080/10715760100301441
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