Cited by 219Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressAdvanced Glycation End Products research

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The Role of Oxidative Stress in Diabetic Vascular and Neural Disease

Yorek, Mark A.·2003·Free Radical Research

DOI 10.1080/1071576031000083161

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Abstract

This review will focus on the impact of hyperglycemia-induced oxidative stress in the development of diabetes-induced vascular and neural dysfunction. Oxidative stress occurs when the balance between the production of oxidation products and the ability of antioxidant mechanisms to neutralize these products is tilted in the favor of the former. The production of reactive oxygen species has been shown to be increased in patients with diabetes. The possible sources for the overproduction of reactive oxygen species is widespread and include enzymatic pathways, autoxidation of glucose and the mitochondria. Increase in oxidative stress has clearly been shown to contribute to the pathology of vascular disease not only in diabetes but also in hypertension, stroke and ischemia. Since the etiology of diabetic neuropathy is considered to have a large vascular component, prevention of oxidative stress in diabetes is considered by many investigators to be a primary defense against the development of diabetic vascular disease. Potential therapies for preventing increased oxidative stress in diabetes and the neural vasculature will be discussed.

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Background
ANTI-DIABETIC EFFECT OF ETHANOL EXTRACT OF Copaifera salikounda (HECKEL) AGAINST ALLOXAN-INDUCED DIABETES IN RATS
Aloke, C., Igwe, E., Obasi, N. A., Amu, P. A., & Egwu, C. O. (2021) · Slovenian Veterinary Research · doi:10.26873/svr-1072-2020 · Cited by 3
“Previous studies reported that hyperglycemia can elicit the generation of ROS and reactive nitrogen species (RNS) by the mitochondrial respiratory system (7), autoxidation of glucose (8), polyol pathway activation (9), production of advanced glycation end products (AGEs) (10), compromised enzyme antioxidant system (11…”
Background
Inhibitory effect of Arctium minus on mitochondrial bioenergetics in diabetic Goto-Kakizaki rats
Ferreira, F. M. L., Peixoto, F., Nunes, E., Sena, C. M., Seiça, R. M. F., & dos Santos, S. M. A. (2010) · Scientific Research and Essays · doi:10.5897/sre.9000598 · Cited by 3
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Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease
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Oxidative Stress and Diabetes-Induced Vascular Dysfunction: Role in Diabetic Neuropathy
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Self-citation
Mitochondria in Diabetes Mellitus
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“Similarities in these two disorders are also found in the risk factor gene polymorphisms, APOE, associated with age-related macular degeneration [99, 100] and Alzheimer’s disease [101, 102].”
Background
Docosahexaenoic Acid Intake and Lipid Peroxidation in Retinal Membranes of Rats
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Relationships between iron, oxidative stress, glycated proteins and the development of atherosclerosis in Type 2 diabetes
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Authors: Yorek, M. A.
Affiliations: University of Iowa (US)
Corresponding author: Yorek, Mark A.
ORCID: Yorek, Mark A.
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2003-01
Volume: 37
Issue: 5
Pages: 471-480
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.1080/1071576031000083161
OpenAlex: W2086273061
Cited by: 219
References: 0
Citations by year: 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 16 · 2013: 12 · 2012: 13
FWCI: 8.62
Type: journal article
Language: en
Open access: closed
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords: oxidative stress, hyperglycemia, diabetes mellitus, diabetic vascular disease, diabetic neuropathy, reactive oxygen species, antioxidant defense, mitochondrial oxidative stress, hypertension, stroke, ischemia, neurovascular dysfunction, antioxidant therapy
MeSH terms: Animals, Diabetes Mellitus, Diabetic Angiopathies, Diabetic Neuropathies, Endothelium, Vascular, Free Radicals, Humans, Models, Biological, Neural Conduction, Reactive Oxygen Species, Oxidative Stress, Diabetes Complications

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The Role of Oxidative Stress in Diabetic Vascular and Neural Disease

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