The DOI matches its Crossref record.
The Role of Oxidative Stress in Diabetic Vascular and Neural Disease
Abstract
This review will focus on the impact of hyperglycemia-induced oxidative stress in the development of diabetes-induced vascular and neural dysfunction. Oxidative stress occurs when the balance between the production of oxidation products and the ability of antioxidant mechanisms to neutralize these products is tilted in the favor of the former. The production of reactive oxygen species has been shown to be increased in patients with diabetes. The possible sources for the overproduction of reactive oxygen species is widespread and include enzymatic pathways, autoxidation of glucose and the mitochondria. Increase in oxidative stress has clearly been shown to contribute to the pathology of vascular disease not only in diabetes but also in hypertension, stroke and ischemia. Since the etiology of diabetic neuropathy is considered to have a large vascular component, prevention of oxidative stress in diabetes is considered by many investigators to be a primary defense against the development of diabetic vascular disease. Potential therapies for preventing increased oxidative stress in diabetes and the neural vasculature will be discussed.
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“However, the therapeutic use of CoQ10 and other antioxidants in vivo, particularly in human studies directed at vascular events, has been disappointing (341, 345).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [341]
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Cardiometabolic Syndrome, Diabetes and Oxidative Stress
Yassine, H. N., & Stump, C. S. (2008) · Modern nutrition · doi:10.1201/9781420059724.ch7
Lunkes, G. I. (2008) · Americanae (AECID Library)
Mitochondria and Oxidative Stress in Diabetes
Sivitz, W. I. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4899-8035-9_5
Molinelli, A. R. (2006) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/7nj0-qw91
Julien, N. G. A. A., Arsène, A. M., KONAN, K. M., et al. (2020) · International Journal Of Medical Science And Clinical Invention · doi:10.18535/ijmsci/v7i12.08
“Hence, alteration in the levels of urea, creatinine, and uric acid in serum, as well as urine, reflected renal dysfunction [19] - [20].”
BackgroundMurray, G. L., & Colombo, J. (2020) · Clinical Cardiology and Cardiovascular Interventions · doi:10.31579/2641-0419/094
VanGilder, R. L. (2009) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.4544
Fabiyi-Edebor, T. D. (2021) · African Journal of Biomedical Research
Sudden Cardiac Death in the General Population: Can We Improve Risk Stratification and Prevention?
Murray, G. L., & Colombo, J. (2021) · International Journal of Angiology · doi:10.1055/s-0041-1729629
Transition metal hexacyanoferrates as catalysts for (bio)sensors
Komkova, M. A., & Karyakin, A. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823144-9.00108-4
Redox Signaling, Oxidative Stress in Cardiovascular Disease –basic Science and Clinical Aspects
Matata, B. M., & Elahi, M. M. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815165012123010004
Is Glycemic Control the Primary Goal in Diabetes Treatment?
Rachiotis, N., Skopeliti, A., & Mitrou, P. (2023) · International Journal of Biomedical and Clinical Analysis · doi:10.61797/ijbca.v3i2.271
Principles of metabolic disorders
Akash, M. S. H., & Rehman, K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36312-2.00001-2
Multidisciplinary Team Intervention Model for Learning Disorder
陶, 朝. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1572161
Metabolic connections between Alzheimer's disease and diabetes
Adhikary, K., Ganguly, K., Chowdhury, S. R., & Banerjee, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33355-2.00024-4
Laffoon, S. B. (2010) · Montana State University ScholarWorks (Montana State University)
High Glucose and Human Endothelial Cell Ageing
Bowers, L.-L. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
The role of glycation and glycoxidation of low-density lipoproteins in foam cell formation.
Brown, B. E. (2004) · The Sydney eScholarship Repository (The University of Sydney)
Metadata
- Authors
- Yorek, M. A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Yorek, Mark A.
- ORCID
- Yorek, Mark A.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 37
- Issue
- 5
- Pages
- 471-480
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2086273061
- Cited by
- 219
- References
- 0
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 16 · 2013: 12 · 2012: 13
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- oxidative stress, hyperglycemia, diabetes mellitus, diabetic vascular disease, diabetic neuropathy, reactive oxygen species, antioxidant defense, mitochondrial oxidative stress, hypertension, stroke, ischemia, neurovascular dysfunction, antioxidant therapy
- MeSH terms
- Animals, Diabetes Mellitus, Diabetic Angiopathies, Diabetic Neuropathies, Endothelium, Vascular, Free Radicals, Humans, Models, Biological, Neural Conduction, Reactive Oxygen Species, Oxidative Stress, Diabetes Complications
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