Cited by 242Antioxidant Activity and Oxidative StressRedox biology and oxidative stressExercise and Physiological Responses

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Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes

Gil, Lizette, Siems, Werner, Mazurek, Birgit, Gross, Johann, Schroeder, Peter, Voss, Peter, Grune, Tilman·2006·Free Radical Research

DOI 10.1080/10715760600592962

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Abstract

Oxidative damage accumulation in macromolecules has been considered as a cause of cellular damage and pathology. Rarely, the oxidative stress parameters in healthy humans related to the individual age have been reported. The purpose of this study was to examine the redox status in plasma and erythrocytes of healthy individuals and determine correlations between these parameters and the aging process. The following parameters were used: malondialdehyde (MDA), protein carbonyls (PCO), 4-hydroxy-2,3-trans-nonenal (HNE), reduced glutathione (GSH), glutathione disulfide (GSSG) and uric acid (UA) in blood and plasma samples of 194 healthy women and men of ages ranging from 18 to 84 years. The results indicate that the balance of oxidant and antioxidant systems in plasma shifts in favor of accelerated oxidation during ageing. That is demonstrated by increases of MDA, HNE, GSSG and by the slight decrease of erythrocytic GSH with age. As the content of UA is more determined by metabolic and nutritional influences than by the balance between prooxidants and antioxidants there was no significant age-related change observed. For plasma concentrations of HNE the first time age-dependent reference values for healthy humans are presented.

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Authors: Gil, L., Siems, W., Mazurek, B., Gross, J., Schroeder, P., Voss, P., & Grune, T.
Affiliations: Instituto de Medicina Tropical “Pedro Kourí” (CU)
Humboldt-Universität zu Berlin (DE)
Heinrich Heine University Düsseldorf (DE)
Corresponding author: Voss, Peter
ORCID: Mazurek, Birgit
Grune, Tilman
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2006-01
Volume: 40
Issue: 5
Pages: 495-505
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.1080/10715760600592962
OpenAlex: W2061523541
Cited by: 242
References: 59
Citations by year: 2026: 2 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 14 · 2015: 18 · 2014: 17 · 2013: 15 · 2012: 13
FWCI: 11.66
Type: journal article
Language: en
Open access: closed
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
Funders: Alexander von Humboldt-Stiftung
Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: oxidative stress, aging, erythrocytes, plasma, malondialdehyde, protein carbonyls, reduced glutathione, glutathione disulfide, uric acid, age-related reference values, prooxidant-antioxidant balance, healthy adults
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Aldehydes, Erythrocytes, Female, Glutathione, Humans, Male, Malondialdehyde, Middle Aged, Oxidation-Reduction, Plasma, Sex Factors, Uric Acid, Biomarkers, Oxidative Stress, Glutathione Disulfide, Protein Carbonylation

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Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes

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