The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo
Abstract
[6]-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger (Zingiber officinale Roscoe, Zingiberaceae) and has diverse pharmacologic effects. Here, we describe its novel anti-oxidant, anti-apoptotic, and anti-inflammatory activities in vitro and in vivo. In vitro, pre-treatment with [6]-gingerol reduced UVB-induced intracellular reactive oxygen species levels, activation of caspase-3, -8, -9, and Fas expression. It also reduced UVB-induced expression and transactivation of COX-2. Translocation of NF-kappaB from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of IkappaBalpha phosphorylation (ser-32). Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 microM) prior to UVB irradiation (5 kJ/m(2)) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-kappaB translocation. These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders.
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Cites
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Sunburn and p53 in the onset of skin cancer
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Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
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“A hallmark of UVB exposure is the induction of apoptotic cell death in keratinocytes, and the results of which are evident within the epidermis as sunburn [54], therefore these results suggest that [6]-gingerol may have a protective effect against UVB-induced damage.”
Result
Cited by
Gingerols and shogaols: Important nutraceutical principles from ginger
Semwal, R. B., Semwal, D. K., Combrinck, S., & Viljoen, A. M. (2015) · Phytochemistry · doi:10.1016/j.phytochem.2015.07.012 · Cited by 607
The response of fish to immunostimulant diets
Vallejos-Vidal, E., Reyes-López, F., Teles, M., & MacKenzie, S. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.06.028 · Cited by 334
Update on the Chemopreventive Effects of Ginger and its Phytochemicals
Baliga, M. S., Haniadka, R., Pereira, M. M., D’Souza, J. J., Pallaty, P. L., Bhat, H. P., & Popuri, S. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408391003698669 · Cited by 294
Oxidative stress–mediated photoactivation of carbazole inhibits human skin cell physiology
Srivastav, A. K., Dubey, D., Chopra, D., Singh, J., Negi, S., Mujtaba, S. F., Dwivedi, A., & Ray, R. S. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29360 · Cited by 16
Metadata
- Authors
- Kim, J.-K., Kim, Y., Na, K.-M., Surh, Y.-J., & Kim, T.-Y.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 41
- Issue
- 5
- Pages
- 603-614
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2006452078
- Cited by
- 221
- References
- 8
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, J.-K., Kim, Y., Na, K.-M., Surh, Y.-J., & Kim, T.-Y. (2007). [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radical Research. https://doi.org/10.1080/10715760701209896
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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