The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Involvement of ROS in BBB dysfunction
Abstract
The blood-brain barrier (BBB) forms a protective barrier around the brain, with the important function of maintaining brain homeostasis. Pathways thought to initiate BBB dysfunction include the kinin system, excitotoxicity, neutrophil recruitment, mitochondrial alterations and macrophage/microglial activation, all of which converge on the same point--reactive oxygen species (ROS). Interestingly, ROS also provide a common trigger for many downstream pathways that directly mediate BBB compromise such as oxidative damage, tight junction (TJ) modification and matrix metalloproteinases (MMP) activation. These observations suggest that ROS are key mediators of BBB breakdown and implicate antioxidants as potential neuroprotectants in conditions like stroke and traumatic brain injury (TBI). This review explores some of the pathways both upstream and downstream of ROS that have been implicated in increased BBB permeability and discusses the role of ROS and antioxidants in neuropathology.
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Cites
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Cited by
Astrocytes: Biology and pathology
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Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
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The blood-brain barrier in aging and neurodegeneration
Knox, E. G., Aburto, M. R., Clarke, G., Cryan, J. F., & O’Driscoll, C. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01511-z · Cited by 738
“The disruption mechanisms of oxidative stress include oxidative damage to cellular components (protein oxidation, lipid peroxidation, and DNA damage), activation of matrix metalloproteinases, cytoskeleton reorganization, modulation of tight junction proteins, and upregulation of inflammatory mediators [81, 86, 87].”
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Metadata
- Authors
- Pun, P. B. L., Lu, J., & Moochhala, S.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 43
- Issue
- 4
- Pages
- 348-364
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2112986223
- Cited by
- 457
- References
- 21
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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