6-mo aerobic exercise intervention enhances the lipid peroxide transport function of HDL
Abstract
During acute exercise, the concentration of oxidized high-density lipoprotein (HDL) lipids (ox-HDL) is reported to increase suggesting that HDL may function in decreasing the concentration of oxidized low-density lipoprotein (LDL) lipids. However, the effect of exercise intervention on the lipid peroxide transport function of HDL is unknown. A randomized controlled trial with sedentary women (N = 161), aged 43-63, with no current use of hormone therapy, were randomized into a 6-month (mo) exercise group and a control group. During the 6-mo intervention, the concentration of ox-HDL increased in the exercise group by 5% and decreased in the control group by 2% (p = .003). Also, the ratio of ox-HDL to HDL-cholesterol increased by 5% in the exercise group and decreased by 1.5% in the control group (p = .036). The concentrations of cholesteryl ester transfer protein (CETP) and adiponectin did not change during the intervention. The concentration of serum triglycerides trended to decrease by 6% in the intervention group (p = .051). We found that the concentration of ox-HDL increased during the 6-mo aerobic exercise intervention, but the increase was not related to changes in the levels of CETP or adiponectin. These results, together with earlier studies, suggest that HDL has an active role in the reverse transport of lipid peroxides.
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Välimäki IA et al. and Tiainen et al. found that exercise could increase oxidized HDL and oxHDL/HDL and decrease oxLDL at the same time.
“Välimäki IA et al. [35] and Tiainen et al. [36] found that exercise could increase oxidized HDL (oxHDL) and oxHDL/HDL and decrease oxLDL at the same time.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [36]
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- Authors
- Tiainen, S., Luoto, R., Ahotupa, M., Raitanen, J., & Vasankari, T.
- Affiliations
- University of Turku (FI)
- Urho Kaleva Kekkonen Institute (FI)
- Tampere University (FI)
- Corresponding author
- Tiainen, Sanna
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2016-11-23
- Volume
- 50
- Issue
- 11
- Pages
- 1279-1285
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2532284998
- Cited by
- 23
- References
- 35
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- aerobic exercise, oxidized HDL, reverse cholesterol transport, cholesteryl ester transfer protein, adiponectin, serum triglycerides, sedentary women, exercise intervention, lipid peroxidation
- MeSH terms
- Adult, Female, Humans, Lipid Peroxides, Lipoproteins, HDL, Middle Aged, Time Factors, Exercise
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