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MSC-mediated mitochondrial transfer promotes metabolic reprograming in endothelial cells and vascular regeneration in ARDS
Open accessAbstract
Background Mesenchymal stem cells (MSCs) are a potential therapy for acute respiratory distress syndrome (ARDS), but their mechanisms in repairing mitochondrial damage in ARDS endothelial cells remain unclear.Methods We first examined MSCs’ mitochondrial transfer ability and mechanisms to mouse pulmonary microvascular endothelial cells (MPMECs) in ARDS. Then, we investigated how MSC-mediated mitochondrial transfer affects the repair of endothelial damage. Finally, we elucidated the mechanisms by which MSC-mediated mitochondrial transfer promotes vascular regeneration.Results Compared to mitochondrial-damaged MSCs, normal MSCs showed a significantly higher mitochondrial transfer rate to MPMECs, with increases of 41.68% in vitro (P < 0.0001) and 10.50% in vivo (P = 0.0005). Furthermore, MSC-mediated mitochondrial transfer significantly reduced reactive oxygen species (P < 0.05) and promoted proliferation (P < 0.0001) in MPMECs. Finally, MSC-mediated mitochondrial transfer significantly increased the activity of the tricarboxylic acid (TCA) cycle (MD of CS mRNA: 23.76, P = 0.032), and further enhanced fatty acid synthesis (MD of FAS mRNA: 6.67, P = 0.0001), leading to a 6.7-fold increase in vascular endothelial growth factor release from MPMECs and promoted vascular regeneration in ARDS.Conclusion MSC-mediated mitochondrial transfer to MPMECs activates the TCA cycle and fatty acid synthesis, promoting endothelial proliferation and pro-angiogenic factor release, thereby enhancing vascular regeneration in ARDS.
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“This is consistent with reports that MSC mitochondrial metabolism is linked to secretion of trophic factors and intercellular communication, in turn impacting function in other cells (Yan et al., 2021; Wang et al., 2025).”
From APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells (2026) · cites this paper as Wang et al., 2025
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Cellular Fatty Acid Metabolism and Cancer
Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123
Acute respiratory distress syndrome
Thompson, B. T., Chambers, R. C., & Liu, K. D. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1608077 · Cited by 1,807
Islam, M. N., Das, S. R., Emin, M. T., Wei, M., Sun, L., Westphalen, K., Rowlands, D. J., Quadri, S. K., Bhattacharya, S., & Bhattacharya, J. (2012) · Nature Medicine · doi:10.1038/nm.2736 · Cited by 1,585
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Schoors, S., Bruning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., et al. (2015) · Nature · doi:10.1038/nature14362 · Cited by 646
Court, A. C., Le‐Gatt, A., Luz‐Crawford, P., Parra, E., Aliaga‐Tobar, V., Bátiz, L. F., Contreras, R. A., Ortúzar, M. I., Kurte, M., Elizondo‐Vega, R., et al. (2020) · The EMBO Reports · doi:10.15252/embr.201948052 · Cited by 259
Chakraborty, R., Nonaka, T., Hasegawa, M., & Zurzolo, C. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05835-8 · Cited by 190
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Research works printed but not linked: 41
- 10.1038/s41572-019-0069-0 · DOI
- 10.1001/jama.2016.0291 · DOI · Paper page
- 10.21037/jtd.2018.08.137 · DOI
- 10.1007/s00134-023-07050-7 · DOI
- 10.1186/s13287-023-03277-9 · DOI
- 10.3389/fimmu.2022.871828 · DOI
- 10.1136/thoraxjnl-2021-217928 · DOI
- 10.3389/fimmu.2021.738697 · DOI
- 10.3390/cells10102588 · DOI
- 10.1016/j.lfs.2021.119876 · DOI
- 10.1016/S0140-6736(21)00439-6 · DOI
- 10.1152/ajpheart.00166.2021 · DOI
- 10.1097/BCR.0000000000000501 · DOI
- 10.1016/j.resp.2010.08.013 · DOI
- 10.1073/pnas.0510511103 · DOI
- 10.1016/j.cmet.2014.12.003 · DOI · Paper page
- 10.1038/s41586-023-06537-z · DOI
- 10.1183/13993003.02978-2020 · DOI
- 10.1136/thoraxjnl-2021-218194 · DOI
- 10.1164/rccm.201701-0170OC · DOI · Paper page
- 10.1186/s13287-022-03219-x · DOI
- 10.1038/s41467-022-28338-0 · DOI
- 10.3389/fimmu.2021.759176 · DOI
- 10.3389/fimmu.2022.973089 · DOI
- 10.1038/s41392-022-01134-4 · DOI · Paper page
- 10.1002/JLB.3MR0321-545RR · DOI
- 10.1016/j.intimp.2021.107694 · DOI
- 10.1016/j.ceb.2021.03.003 · DOI
- 10.3389/fcell.2022.915117 · DOI
- Ahmad T, Mukherjee S, Pattnaik B, et al. Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. Embo J. 2014;33 (9):994–1010.
- 10.3389/fcvm.2021.771298 · DOI
- 10.1038/s41586-020-2589-x · DOI · Paper page
- Wick KD, Ware LB, Matthay MA. Acute respiratory distress syndrome. BMJ (Clinical Research ed). 2024;387:e076612.
- 10.3892/etm.2022.11406 · DOI
- 10.1186/s13287-019-1488-2 · DOI · Paper page
- 10.1159/000438545 · DOI
- 10.1016/j.cmet.2018.07.016 · DOI
- 10.1016/j.cmet.2020.12.006 · DOI
- 10.1016/j.ejphar.2018.05.003 · DOI
- 10.3390/ijms222313057 · DOI
- 10.1038/s41467-019-13668-3 · DOI · Paper page
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Rodriguez Martinez, P. J., Yslas, A. R., Inoue, Y., Parsons, T. M., Baker, S. K., Lu, W., Raulin, A.-C., & Kanekiyo, T. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1778856
Metadata
- Authors
- Wang, J., Meng, S., Chen, Y., Wang, H., Hu, W., Liu, S., Huang, L., Xu, J., Li, Q., Wu, X., Huang, W., & Huang, Y.
- Affiliations
- Zhongda Hospital Southeast University (CN)
- Corresponding author
- Huang, Yingzi
- ORCID
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 2025-03-13
- Volume
- 30
- Issue
- 1
- Pages
- 2474897-2474897
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- PMC
- PMC11912292
- OpenAlex
- W4408464831
- Cited by
- 25
- References
- 6
- Citations by year
- 2026: 14 · 2025: 11
- FWCI
- 16.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Report (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key R&D Program of China (2022YFC2304600)
- National Natural Science Foundation of China (82272235, 82102300, 82272211, 82302470)
- Science Foundation of the Commission of Health of Jiangsu Province (ZDB2020009)
- Jiangsu Province Key research and development Program (Social Development) Special Project (BE2021734)
- China Postdoctoral Science Foundation (2022M710685)
- Special fund project for health science and technology development of Nanjing Municipal Health Commission (YKK21265)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mesenchymal stem cells, mitochondrial transfer, acute respiratory distress syndrome, endothelial cells, vascular regeneration, metabolic reprogramming, TCA cycle, fatty acid synthesis, reactive oxygen species, endothelial cell proliferation, vascular endothelial growth factor, angiogenesis, mitochondrial damage
- MeSH terms
- Animals, Cells, Cultured, Humans, Male, Mice, Inbred C57BL, Mitochondria, Regeneration, Respiratory Distress Syndrome, Reactive Oxygen Species, Endothelial Cells, Cell Proliferation, Mice, Mesenchymal Stem Cells
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