A patent review of berberine and its derivatives with various pharmacological activities (2016–2020)

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.019 · Cited by 3,720 · see citing works

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

Zhang, X., Zhao, Y., Xu, J., Xue, Z., Zhang, M., Pang, X., Zhang, X., & Zhao, L. (2015) · Scientific Reports · doi:10.1038/srep14405 · Cited by 630 · see citing works

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

Zhang, X., Zhao, Y., Zhang, M., Pang, X., Xu, J., Kang, C., Li, M., Zhang, C., Zhang, Z., Zhang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042529 · Cited by 615 · see citing works

Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats

Chen, W., Miao, Y.-Q., Fan, D.-J., Yang, S.-S., Lin, X., Meng, L.-K., & Tang, X. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9632-z · Cited by 363 · see citing works

Transforming berberine into its intestine-absorbable form by the gut microbiota

Feng, R., Shou, J.-W., Zhao, Z.-X., He, C.-Y., Ma, C., Huang, M., Fu, J., Tan, X.-S., Li, X.-Y., Wen, B.-Y., et al. (2015) · Scientific Reports · doi:10.1038/srep12155 · Cited by 307 · see citing works

Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route

Anderberg, E. K., Lindmark, T., & Artursson, P. (1993) · Pharmaceutical Research · doi:10.1023/a:1018909210879 · Cited by 221 · see citing works

Berberine stimulates glucose transport through a mechanism distinct from insulin

Zhou, L., Yang, Y., Wang, X., Liu, S., Shang, W., Yuan, G., Li, F., Tang, J., Chen, M., & Chen, J. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.025 · Cited by 187 · see citing works

Berberine and its derivatives: a patent review (2009 – 2012)

Singh, I. P., & Mahajan, S. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.746314 · Cited by 181 · see citing works

Pharmacological effects of berberine and its derivatives: a patent update

Jin, Y., Khadka, D. B., & Cho, W. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2016.1118060 · Cited by 174 · see citing works

The UHRF family: Oncogenes that are drugable targets for cancer therapy in the near future?

Bronner, C., Achour, M., Arima, Y., Chataigneau, T., Saya, H., & Schini‐Kerth, V. B. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.003 · Cited by 159 · see citing works

Nanostructured MoO3 for Efficient Energy and Environmental Catalysis

Zhu, Y., Yao, Y., Luo, Z., Pan, C., Yang, J., Fang, Y., Deng, H., Liu, C., Tan, Q., Liu, F., et al. (2019) · Molecules · doi:10.3390/molecules25010018 · Cited by 154 · see citing works

Disruption of Dnmt1/PCNA/UHRF1 Interactions Promotes Tumorigenesis from Human and Mice Glial Cells

Hervouet, É., Lalier-Bretaudeau, L., Debien, E., Cheray, M., Geairon, A., Rogniaux, H., Loussouarn, D., Martin, S. A., Vallette, F. M., & Cartron, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011333 · Cited by 151 · see citing works

Berberine Activates GLUT1-Mediated Glucose Uptake in 3T3-L1 Adipocytes

Kim, S. H., Shin, E.-J., Kim, E.-D., Bayaraa, T., Frost, S. C., & Hyun, C. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.2120 · Cited by 136 · see citing works

Solid dispersion of berberine–phospholipid complex/TPGS 1000/SiO2: preparation, characterization and in vivo studies

Zhang, Z., Chen, Y., Deng, J. G., Jia, X., Zhou, J., & Lv, H. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.01.023 · Cited by 135 · see citing works

An insight into the medicinal attributes of berberine derivatives: A review

Gaba, S., Saini, A., Singh, G., & Monga, V. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116143 · Cited by 123 · see citing works

Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell

Yao, M., Fan, X., Yuan, B., Takagi, N., Liu, S., Han, X., Ren, J., & Liu, J. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2615-4 · Cited by 121 · see citing works

Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity

Zeng, Q., Deng, H., Li, Y., Fan, T., Liu, Y., Tang, S., Wei, W., Liu, X., Guo, X., Jiang, J., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01743 · Cited by 119 · see citing works

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

Belwal, T., Bisht, A., Devkota, H. P., Ullah, H., Khan, H. Z., Pandey, A., BHATT, I. D., & Echeverría, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00041 · Cited by 115 · see citing works

Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride

Zhu, J.-X., Tang, D., Feng, L., Zheng, Z., Wang, R.-S., Wu, A., Duan, T., He, B., & Quan, Z. (2012) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2012.683875 · Cited by 113 · see citing works

Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis

Tian, B., Tian, M., & Huang, S.-M. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1741651 · Cited by 99 · see citing works

Inhibition of the Bacterial Surface Protein Anchoring Transpeptidase Sortase by Isoquinoline Alkaloids

Kim, S.-H., Shin, D., Oh, M., Chung, S., Jang-Suk, L. E. E., & Oh, K. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.421 · Cited by 95 · see citing works

Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability

Meng, Z., Zhang, M., Shengnan, W., Xiaojia, B., Hatch, G. M., Gu, J., & Li, C. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.03.017 · Cited by 86 · see citing works

Antimicrobial Activity of 8-Alkyl- and 8-Phenyl-Substituted Berberines and Their 12-Bromo Derivatives

Iwasa, K., Lee, D., Kang, S.-I., & Wiegrebe, W. (1998) · Journal of Natural Products · doi:10.1021/np980044+ · Cited by 84 · see citing works

Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

Wei, S., Zhang, M., Yu, Y., Lan, X., Yao, F., Yan, X., Chen, L., & Hatch, G. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152097 · Cited by 84 · see citing works

Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity

Chen, Q., Ren, R., Zhang, Q., Wu, J., Zhang, Y., Xue, M.-S., Yin, D., & Yang, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113542 · Cited by 80 · see citing works

Chenodeoxycholic Acid

Iser, J. H., & Sali, A. (1981) · Drugs · doi:10.2165/00003495-198121020-00002 · Cited by 79 · see citing works

Synergistic potential of dual andrographolide and melatonin targeting of metastatic colon cancer cells: Using the Chou-Talalay combination index method

Banerjee, V., Sharda, N., Huse, J., Singh, D., Sokolov, D., Czinn, S. J., Blanchard, T. G., & Banerjee, A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173919 · Cited by 79 · see citing works

Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma

Li, Z., Zheng, J., Zhang, N., & Li, C. (2016) · Journal of Asthma · doi:10.1080/02770903.2016.1180530 · Cited by 75 · see citing works

Berberine Suppresses Cell Motility Through Downregulation of TGF-β1 in Triple Negative Breast Cancer Cells

Kim, S., Lee, J., You, D., Jeong, Y., Jeon, M., Yu, J., Kim, S. W., Nam, S. J., & Lee, J. E. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000487171 · Cited by 74 · see citing works

Berberine acutely activates the glucose transport activity of GLUT1

Cok, A., Rosenberger, C. L., Salie, M. J., Oram, D. S., Chenge, J., & Louters, L. L. (2011) · Biochimie · doi:10.1016/j.biochi.2011.04.013 · Cited by 73 · see citing works

8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models

Cheng, Z., Chen, A.-F., Wu, F., Li, S., Zhang, H., Gu, M., Li, Y., Zhang, L.-N., Hu, L., Li, J.-Y., et al. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.06.085 · Cited by 71 · see citing works

Non-coding RNAs and Berberine: A new mechanism of its anti-diabetic activities

Chang, W. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.055 · Cited by 66 · see citing works

Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma by inhibiting inflammation and angiogenesis in mice.

Luo, Y., Tian, G., Zhuang, Z., Chen, J., You, N., Zhuo, L., Liang, B., Song, Y., Zang, S., Liu, J., et al. (2019) · PubMed Central · Cited by 66 · see citing works

Berberine Derivatives with Different Pharmacological Activities via Structural Modifications

Xiao, D., Liu, Z., Zhang, S., Zhou, M., He, F., Zou, M., Peng, J., Xie, X., Liu, Y., & Peng, D. (2018) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557517666170321103139 · Cited by 65 · see citing works

Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth

Li, D., Zhang, Y., Liu, K., Zhao, Y., Xu, B., Xu, L., Tan, L., Tian, Y., Li, C., Zhang, W., et al. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.71 · Cited by 65 · see citing works

Berberine—A potent chemosensitizer and chemoprotector to conventional cancer therapies

Devarajan, N., Jayaraman, S., Mahendra, J., Venkatratnam, P., Rajagopal, P., Palaniappan, H., & Ganesan, S. K. (2021) · Phytotherapy Research · doi:10.1002/ptr.7032 · Cited by 65 · see citing works

Berberine: A potential adjunct for the treatment of gastrointestinal cancers?

Hesari, A., Ghasemi, F., Cicero, A. F. G., Mohajeri, M., Rezaei, O., Hayat, S. M. G., & Sahebkar, A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27392 · Cited by 63 · see citing works

Berberine: A naturally occurring phototoxic alkaloid

Philog�ne, B. J. R., Arnason, J. T., Towers, G. H. N., Abramowski, Z., Campos, F., Champagne, D. E., & McLachlan, D. (1984) · Journal of Chemical Ecology · doi:10.1007/bf00987648 · Cited by 62 · see citing works

Pharmaceutical Co-crystals, Salts, and Co-amorphous Systems: A novel opportunity of hot-melt extrusion

Narala, S., Nyavanandi, D., Srinivasan, P., Mandati, P., Bandari, S., & Repka, M. A. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102209 · Cited by 62 · see citing works

Comprehensive Study in the Inhibitory Effect of Berberine on Gene Transcription, Including TATA Box

Wang, Y., Kheir, M. M., Chai, Y., Hu, J., Xing, D., Fan, L., & Du, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023495 · Cited by 56 · see citing works

Structural modification of berberine alkaloids in relation to cytotoxic activity in vitro

Orfila, L., Rodrı́guez, M., Colman, T., Hasegawa, M., Merentes, E., & Arvelo, F. A. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00177-x · Cited by 54 · see citing works

Proanthocyanidins Should Be a Candidate in the Treatment of Cancer, Cardiovascular Diseases and Lipid Metabolic Disorder

Wang, T. K., Xu, S., Li, S., & Zhang, Y. (2020) · Molecules · doi:10.3390/molecules25245971 · Cited by 52 · see citing works

Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine

Li, Y., Li, Y., Yang, P., Kong, W., You, X., Ren, G., Deng, H., Wang, Y., Wang, Y., Jiang, J., et al. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.06.106 · Cited by 51 · see citing works

Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure–Activity Relationships

Okubo, S., Uto, T., Goto, A., Tanaka, H., Nishioku, T., Yamada, K., & Shoyama, Y. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x17500811 · Cited by 51 · see citing works

Efficacy and safety of berberine alone or combined with statins for the treatment of hyperlipidemia: A systematic review and meta-analysis of randomized controlled clinical trials

Zhang, L.-S., Zhang, J.-H., Feng, R., Jin, X.-Y., Yang, F.-W., Ji, Z.-C., Zhao, M.-Y., Zhang, M.-Y., Zhang, B.-L., & Li, X.-M. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500393 · Cited by 50 · see citing works

Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives

Zhang, S., Wang, X., Yin, W., Liu, Z., Zhou, M., Xiao, D., Liu, Y., & Peng, D. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.08.027 · Cited by 49 · see citing works

Two telomerase-targeting Pt( ii ) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells

Qin, Q., Wang, Z., Huang, X., Tan, M., Luo, Z., Wang, S.-L., Zou, B., & Liang, H. (2019) · Dalton Transactions · doi:10.1039/c9dt02381j · Cited by 49 · see citing works

Enhancement by sodium caprate and sodium deoxycholate of the gastrointestinal absorption of berberine chloride in rats

Fan, D., Wu, X., Dong, W., Sun, W., Li, J., & Tang, X. (2012) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2012.723219 · Cited by 46 · see citing works

The enhancement of cardiac toxicity by concomitant administration of berberine and macrolides

Zhi, D., Feng, P.-F., Sun, J.-L., Guo, F., Zhang, R., Zhao, X., & Li, B.-X. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.05.009 · Cited by 45 · see citing works

Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs

Li, D., Yu, P., Xiao, W., Wang, Z., & Zhao, L.-G. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200908165913 · Cited by 44 · see citing works

Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery

Chang, L., Campbell, J. C., Raji, I. O., Guduru, S. K. R., Kandel, P., Nguyen, M., Liu, S., Tran, K., Venugopal, N. K., Taylor, B. C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80588-4 · Cited by 38 · see citing works

Berberine-induced nucleolar stress response in a human breast cancer cell line

Sakaguchi, M., Kitaguchi, D., Morinami, S., Kurashiki, Y., Haruna, H., Miyata, S., Yamaguchi, M., Sakai, M., Murata, N., & Tanaka, S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.020 · Cited by 26 · see citing works

Study of alkaloid berberine and its interaction with the human telomeric i-motif DNA structure.

Gargallo, R., Aviñó, A., Eritja, R., Jarošová, P., Mazzini, S., Scaglioni, L., & Táborský, P. (2020) · Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2020.119185 · Cited by 26 · see citing works

Recent Advances in Nucleic Acid Binding Aspects of Berberine Analogs and Implications for Drug Design

Bhowmik, D., & Kumar, G. S. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150909144425 · Cited by 25 · see citing works

Effect of Berberine on Monocyte Chemotactic Protein-1 and Cytokine-Induced Neutrophil Chemoattractant-1 Expression in Rat Lipopolysaccharide-Induced Uveitis

Cui, H.-S., Hayasaka, S., Zheng, L., Hayasaka, Y., Zhang, X.-Y., & Chi, Z. (2006) · Ophthalmic Research · doi:10.1159/000097904 · Cited by 20 · see citing works

A New Co-Crystal of Synthetic Drug Rosiglitazone with Natural Medicine Berberine: Preparation, Crystal Structures, and Dissolution

Guan, X., Jiang, L., Cai, L., Zhang, L., & Hu, X. (2020) · Molecules · doi:10.3390/molecules25184288 · Cited by 18 · see citing works

Discovery of C-9 Modified Berberine Derivatives as Novel Lipid-Lowering Agents

Li, D., Yu, P., Xu, H. W., Wang, Z., Xiao, W., & Zhao, L.-G. (2020) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c20-00453 · Cited by 18 · see citing works

Two new quaternary protoberberine alkaloids fromCorydalis yanhusuo

Zhou, Q., Deng, A., & Qin, H. (2012) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2012.677038 · Cited by 16 · see citing works

Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study

Lu, P., Li, X., Zhu, N., Deng, Y., Cai, Y., Zhang, T., Liu, L., Lin, X., Guo, Y., & Han, M. (2020) · PeerJ · doi:10.7717/peerj.10130 · Cited by 13 · see citing works

A pyrolytic route to the phthalide-isoquinolines

Elango, V., & Shamma, M. (1983) · The Journal of Organic Chemistry · doi:10.1021/jo00173a019 · Cited by 12 · see citing works

Photodynamic Therapy Enhanced the Antitumor Effects of Berberine on HeLa Cells

Liu, H., An, Y., Hu, A., Li, M., & Cui, G. (2019) · Open Chemistry · doi:10.1515/chem-2019-0048 · Cited by 11 · see citing works

Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial

León-Martínez, J. M., Martínez‐Abundis, E., González-Ortı́z, M., & Pérez-Rubio, K. G. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2020.0029 · Cited by 11 · see citing works

An experimental study on the photodynamic activity of berberine in vitro on cancer cells.

Mx, W., Lm, H., Hc, Y., Yj, G., & E, Z. (1986) · PubMed · Cited by 7 · see citing works

The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Guo, J., Chen, H., Zhang, X., Lou, W., Zhang, P., Qiu, Y., Zhang, C., Wang, Y., & Liu, W. J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2074610 · Cited by 110 · see citing works

Oxyberberine ameliorates TNBS-induced colitis in rats through suppressing inflammation and oxidative stress via Keap1/Nrf2/NF-κB signaling pathways

Li, C., Liu, M., Deng, L., Luo, D., Ma, R., & Lü, Q. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154899 · Cited by 85 · see citing works

Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development

Wang, L., Yan, Y., Wu, L., & Peng, J. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106925 · Cited by 74 · see citing works

Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria

Zhou, H., Wang, W., Cai, L., & Yang, T. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s431256 · Cited by 71 · see citing works

Berberine and berberine nanoformulations in cancer therapy: Focusing on lung cancer

Hsu, C., Pallathadka, H., Gupta, J., Ma, H., Al-Shukri, H. H. K., Kareem, A. K., Zwamel, A. H., & Mustafa, Y. F. (2024) · Phytotherapy Research · doi:10.1002/ptr.8255 · Cited by 60 · see citing works

Effect of dietary barberry fruit (Berberis vulgaris) extract on immune function, antioxidant capacity, antibacterial activity, and stress-related gene expression of Siberian sturgeon (Acipenser baerii)

Shekarabi, S. P. H., Mehrgan, M. S., Ramezani, F., Dawood, M. A. O., Doan, H. V., Moonmanee, T., Hamid, N. K. A., & Kari, Z. A. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101041 · Cited by 47 · see citing works

Role of Berberine as a Potential Efflux Pump Inhibitor against MdfA from Escherichia coli: In Vitro and In Silico Studies

Li, Y., & Ge, X. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03324-22 · Cited by 43 · see citing works

Pharmacological properties and therapeutic potential of berberine: a comprehensive review

Fan, K.-Q., Zhang, L., Song, F., Zhang, Y., Chen, T., Cheng, X., Su, N., Zou, Y., Yu, T., Tan, F., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1604071 · Cited by 33 · see citing works

Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis

Gangwar, T., Poonia, N., Subudhi, R. N., & Arora, V. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03811-x · Cited by 26 · see citing works

Berberine-Encapsulated Poly(lactic-co-glycolic acid)–Hydroxyapatite (PLGA/HA) Microspheres Synergistically Promote Bone Regeneration with DOPA-IGF-1 via the IGF-1R/PI3K/AKT/mTOR Pathway

Chen, L., Tian, M., Yang, J., & Wu, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015403 · Cited by 23 · see citing works

Discovery and structural optimization of 9-O-phenylsulfonyl-berberines as new lipid-lowering agents

Kong, Y., Yi, Y.-J., Liu, X., Yu, P., Zhao, L., & Li, D. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105665 · Cited by 23 · see citing works

Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease

Gao, K., Liu, Y., Li, K., Liu, L., Cai, Y., Zhang, X., & Zhao, Z. (2025) · Phytotherapy Research · doi:10.1002/ptr.8498 · Cited by 20 · see citing works

Preparation and Evaluation of Berberine-Excipient Complexes in Enhancing the Dissolution Rate of Berberine Incorporated into Pellet Formulations

Abbaspour, M., Faeznia, F., Zanjanian, P., Ruzbehi, M., Shourgashti, K., Ziaee, A., Sardou, H. S., & Nokhodchi, A. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02863-1 · Cited by 18 · see citing works

Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model

Wang, Y., Zhao, D., Su, L., Tai, Y., Way, G. W., Zeng, J., Yan, Q., Xu, Y., Wang, X., Gurley, E. C., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01195-8 · Cited by 14 · see citing works

Traditional Chinese medicine and gut microbiota: biotransformation, interaction, and implications for chronic disease treatment

Hao, X., Zhang, J., Ma, R., Yao, B., & Yang, W. (2025) · Drug Metabolism Reviews · doi:10.1080/03602532.2025.2520768 · Cited by 13 · see citing works

Exploring the perspectives of phytobiotics and their role in aquaculture: Present status and future trends

Pudota, B. A., Neeraja, T., Chennu, R., Lavanya, C., Shaik, H., Nadella, R. K., Chatterjee, N. S., & Paturi, A. P. (2025) · The Microbe · doi:10.1016/j.microb.2025.100496 · Cited by 12 · see citing works

Berberine hydrochloride alleviates chronic prostatitis/chronic pelvic pain syndrome by modifying gut microbiome signaling

Tian, Y., Ren, X., Wang, J., Li, X., Yin, Y., Guo, Z., Qin, Z.-L., & Zeng, X.-Y. (2024) · Asian Journal of Andrology · doi:10.4103/aja202427 · Cited by 10 · see citing works

Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells

Feng, Q., Hu, K., Hu, H., Lu, Y., Zhang, H., Wang, G., Zhang, Q., Xu, Z., Gao, X., Jia, X., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111139 · Cited by 9 · see citing works

Thalictrum foliolosum DC against aphid, Aphis craccivora Koch and mealybug, Planococcus lilacinus Cockerell: A potential bioinsecticide

Bhatt, P. M., Chauhan, N., Kashyap, U., Sendri, N., Bhandari, P., & Reddy, S. G. E. (2024) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2024.103326 · Cited by 9 · see citing works

Enhanced developing property of latent fingerprint based on inclusion complex of β-cyclodextrin with natural berberine extracted from Coptis chinensis

Zhou, H., Shi, W., Liu, J., Su, G., Cui, S., Zhang, M., & Li, S. (2022) · Chemical Papers · doi:10.1007/s11696-022-02216-x · Cited by 7 · see citing works

Inactivation of CYP2D6 by Berberrubine and the Chemical Mechanism

Rao, J., Wang, T., Yu, L., Wang, K., & Qiu, F. (2024) · Biochemistry · doi:10.1021/acs.biochem.4c00450 · Cited by 6 · see citing works

Elite chemotype selection, antipathogenic activities, secondary metabolite fingerprinting of in vitro regenerated Tinospora cordifolia (Willd.) Hook.f. & Thomson – a plant with multipurpose therapeutic significance

Chakraborty, A., Mukherjee, S., Biswas, D., Santra, I., Halder, T., Alam, M. M., Bera, K., & Ghosh, B. (2024) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-024-02726-4 · Cited by 6 · see citing works

Dihydroberberine normalizes insulin secretion by regulating glucokinase

Zhang, C., Zhang, X., Zhang, Q., Zhao, R., Xiong, F., Wei, G., Ke, X., & Lü, J. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70171 · Cited by 5 · see citing works

A comprehensive compendium of berberine: sources, chemistry, and pharmacological activities

Mohapatra, N., Singh, T. G., Kumar, M. S., & Awasthi, A. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70394 · Cited by 4 · see citing works

Discovery of berberine derivatives@chitosan nanoparticles for controlling plant canker diseases

Zhu, M. J., Chen, D., Li, C., & Ouyang, G. (2025) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2025.111054 · Cited by 4 · see citing works

Barberry (Berberis spp.) Domestication and Breeding

Rezaei, M., & Sarkhosh, A. (2025) · Advances in plant breeding strategies · doi:10.1007/978-3-031-81846-2_2 · Cited by 4 · see citing works

Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives

Khvostov, M. V., Gladkova, E. D., Борисов, С. А., Fedotova, M. S., Zhukova, N., Marenina, M. K., Meshkova, Y. V., Luzina, O. A., Tolstikova, T. G., & Salakhutdinov, N. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214186 · Cited by 4 · see citing works

Cytotoxic effects of aporphine alkaloids from the stems and leaves of Stephania dielsiana Y.C.Wu

Hiền, T. T. T., Ba, V. L., Huy, N. Q., Thảo, N. P., Yang, S. Y., & Van, L. T. K. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2227911 · Cited by 4 · see citing works

Phytoconstituents as therapeutic agents in combating methotrexate-induced hepatotoxicity and nephrotoxicity

Dogra, A., Paine, M. F., MacKenzie, K. R., & Li, F. (2025) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2025.2585435 · Cited by 3 · see citing works

Berberine Hydrochloride Reduces the Intracellular Survival of Salmonella Typhimurium by Enhancing Host Autophagic Flux Through the Inhibition of the Type III Secretion System

Huang, J., Lu, J., Wu, C., Chen, S., Chang, T., Xu, L., Shen, X., Bakhsh, Q., Qin, B., Qian, W., et al. (2025) · Biomolecules · doi:10.3390/biom15111589 · Cited by 3 · see citing works

Berberine in cardiovascular therapy: bridging modern pharmacology with the traditional Chinese botanicals Huanglian (黄连), Huangbai (黄柏), Amur Cork Tree (黄檗), and Gong Lao Mu (亮叶十大功劳)

Sharma, S., & Tanwar, S. S. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100635 · Cited by 3 · see citing works

Development of Ethyl Cellulose and Lecithin Nanoparticles: Permeability Enhancement for Berberine Topical Application

Luong, A. Q., Le, T. U., Nguyen, T. P. N., Tran, T. H., & Tran, B. N. (2024) · BioNanoScience · doi:10.1007/s12668-024-01687-4 · Cited by 3 · see citing works

The Combination of Natural Products with Biomaterials for Regenerative Medicine: Current Trends

Janani, B. M., Srinivasan, S., Vijayalekha, A., & Pandurangan, A. K. (2025) · Current Pharmacology Reports · doi:10.1007/s40495-025-00421-2 · Cited by 2 · see citing works

Berberine ameliorates estrogen deficiency-associated bone loss via inducing tuft cell expansion

Du, Q., Zhang, Z., Tu, Y., Zheng, X., Peng, X., Liu, R., Xie, Q., Zhou, X., Zheng, L., & Xu, X. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158058 · Cited by 2 · see citing works

DFT, ADME studies and evaluation of the binding with HSA and MAO-B inhibitory potential of protoberberine alkaloids from Guatteria friesiana: theoretical insights of promising candidates for the treatment of Parkinson’s disease

Tananta, V. L., Costa, E. V., Mary, Y. S., Mary, Y. S., Al-Otaibi, J. S., & Costa, R. A. (2023) · Journal of Molecular Modeling · doi:10.1007/s00894-023-05756-5 · Cited by 2 · see citing works

High-throughput sequencing reveals twelve cell death pattern prognostic target genes as potential drug-response-associated genes in the treatment of colorectal cancer cells with palmatine hydrochloride

Luo, S., Xu, J., Mo, C., Gong, W., Li, C., Hou, X., & Ou, M. (2024) · ONCOLOGIE · doi:10.1515/oncologie-2024-0378 · Cited by 1 · see citing works

Reclaiming the Microbial Battlefield: Adjuvant Strategies to Overcome Antibiotic Resistance

Sun, J., Li, D. W.-C., Wu, T., Yang, Z., Ye, D., & Guo, K. (2026) · Microorganisms · doi:10.3390/microorganisms14030609 · Cited by 1 · see citing works

Berberine as a multifunctional additive in biopolymer-based food packaging films and coatings: A review

Li, X. C., Guo, J., Zhang, W., Bagri, F., Karaça, A. C., Rawdkuen, S., & Tian, W. (2026) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2026.105922 · Cited by 1 · see citing works

Development and Validation of Analytical Method for Estimation of Berberine in Herbal Extract of Momordica Dioica

Tonape, A., Neve, V., Darbhe, J., & Bhalchim, V. M. (2023) · International Journal of Ayurvedic Medicine · doi:10.47552/ijam.v14i2.3637 · Cited by 1 · see citing works

Oxyberberine protects middle cerebral artery occlusion triggered cerebral injury through TLR4/NLRP3 pathway in rats

Rahman, Z., Shaikh, A. S., Rao, K. V., & Dandekar, M. P. (2024) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2024.102393 · Cited by 1 · see citing works

Evaluation of Beta-cell Regeneration Property of Methanolic Extract of Momordica Dioica in Wistar Rat Model

Neve, V., Tonape, A., Bhalchim, V. M., Karwa, P. N., & Panbhare, K. (2024) · International Journal of Pharmaceutical Sciences and Nanotechnology · doi:10.37285/ijpsn.2024.17.4.5 · Cited by 1 · see citing works

Insights of Natural Isoquinoline Alkaloids in the Management of Trachoma

Kaushik, M., Kaushik, A., Gautam, S. P., & Baral, D. (2025) · Current Bioactive Compounds · doi:10.2174/0115734072351741250318232624

Isoquinoline Quaternary Alkaloid (IQA) Nano-dressings: A Comprehensive Review on Design Strategies, Therapeutic Applications, and Advancements in Transdermal Delivery for Chronic Wound Management

Jahan, I., Hak, J., Mandal, S. K., Ali, S., Ali, S. A., & Farooqui, N. A. (2025) · Recent Advances in Drug Delivery and Formulation · doi:10.2174/0126673878330005250326060103

Polypharmacological mechanisms of Berberine and its derivatives in Chronic Inflammatory Diseases: An OverviewPreprint

Banerjee, R., Roy, A., & Banerjee, A. G. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5352280

Advances in traditional Chinese medicine for burn treatment: mechanisms, therapeutic approaches, and innovative preparations

Liu, Y., Yu, C., Dou, T., Shen, Y., He, L., Liu, M., Wenying, X., Zeng, W., Feng, Z., Huang, M., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1651219

Two Drug–Drug Co-Amorphous Systems of Curcumin and Berberine Hydrochloride/Palmatine Hydrochloride with Improved Physicochemical Properties and Multifunctional Activities

Zhang, Y., Guo, Q., Liang, L., Zhang, M., Sa, R., & Lou, B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics18010009

In Silico Docking Study of Berberine Derivatives as AMPK Activators for Diabetes Mellitus via Multi-Target Protein Approach.

Anap, H. N., Eknath, N. S., Bhagat, J. R., Medge, V. A., Katore, S. V., Pagare, N. V., Kurkute, D. G., Jadhav, S. E., & Bhor, R. J. (2025) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3468

Research Progress of Berberine in the Treatment of Periodontitis

廖, 洋. (2026) · Medical Diagnosis · doi:10.12677/md.2026.161025

Pharmacokinetics and Bioavailability of Natural Compounds

TABASSUM, R., HABIB, S., RAMZAN, A., Godya, Z., BIBI, A., SHAHARYAR, M., Salar, M. Z., & WAHAB, A. (2025) · doi:10.61748/npbr.2025/03

A novel berberine derivative B12 exhibits superior anti-obesity effects via targeting brown and white adipocyte dynamics

Zhang, W., Feng, Y., Gao, C., Zhong, L., Wang, W., Xu, M., Zheng, B., Zhang, Y., Wang, S., Yi, S., et al. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02153-9

Targeting p66Shc by natural-derived and synthetic compounds in organ toxicity

Yarmohammadi, F., Shabani, S., & Karimi, G. (2026) · Human & Experimental Toxicology · doi:10.1177/09603271261494653

Pharmacological effects of berberine and its derivatives: a patent update

Jin, Y., Khadka, D. B., & Cho, W. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2016.1118060 · Cited by 174 · see citing works

[Advances in the study of berberine and its derivatives].

Li, B., Zhu, W., & Chen, K. (2008) · PubMed · Cited by 23 · see citing works

Berberine: A Comprehensive Review on its Isolation, Biosynthesis, Chemistry and Pharmacology

Ali, F., Alom, S., & Zaman, K. (2021) · Asian Journal of Chemistry · doi:10.14233/ajchem.2021.23365 · Cited by 11 · see citing works

An insight into the medicinal attributes of berberine derivatives: A review

Gaba, S., Saini, A., Singh, G., & Monga, V. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116143 · Cited by 123 · see citing works

Antimicrobial compounds of berberines:research advances

Fang, B., ChengHe, Z., & Zhou, X. (2010) · Guoji yaoxue yanjiu zazhi · Cited by 5 · see citing works