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Cited by 117Schizophrenia research and treatmentDementia and Cognitive Impairment ResearchNeurobiology of Language and Bilingualism

Is semantic memory impaired in schizophrenia? A systematic review and meta-analysis of 91 studies.

Doughty, O. J., Done, D. J.·2009·Cognitive Neuropsychiatry
DOI 10.1080/13546800903073291
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Abstract

INTRODUCTION: Semantic memory impairments in schizophrenia have been reported across a wide range of neuropsychological tests. Set against a backdrop of fairly widespread cognitive impairments, it is difficult to know whether there is a primary, or secondary, impairment of semantic memory in schizophrenia. Also, whether there is a profile of differential impairment across the range of neuropsychological tests. METHODS: Employing a systematic search strategy, 91 papers were identified which have assessed participants with schizophrenia on a measure of semantic memory. A series of meta-analyses were then conducted which provided combined weighted means for performance on tasks of naming, word-picture matching, verbal fluency, priming, and categorisation. RESULTS: An uneven profile of impairment is reported with large effect sizes for tests of naming and verbal fluency, medium effect sizes for word-picture matching and association and small effect sizes for categorisation and priming tests. CONCLUSIONS: This uneven profile supports the claim that a degradation of semantic knowledge may not be adequate in explaining the semantic memory impairment in schizophrenia. This conclusion is supported by the data which report a relationship between an executive dysfunction and poor priming and fluency performance particularly. The data support a link between Formal Thought Disorder and semantic memory impairments on tests of naming and verbal fluency but on other tests evidence is equivocal.

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  • A meta-analysis found that individuals with schizophrenia have large deficits on semantic verbal fluency both for switching between subcategories, an index of EF, and semantic clustering, an index of semantic memory.

    “For example, a meta-analysis found that individuals with schizophrenia have large deficits on semantic verbal fluency both for switching between subcategories, an index of EF, and semantic clustering, an index of semantic memory (Doughty and Done, 2009).”

    From Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches (2015) · cites this paper as Doughty and Done, 2009

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Authors
Doughty, O. J., & Done, D. J.
Affiliations
University of Hertfordshire (GB)
Corresponding author
Doughty, O. J.
ORCID
Done, D. J.
Venue
Cognitive Neuropsychiatry
Publisher
Informa UK Limited
Published
2009-11
Volume
14
Issue
6
Pages
473-509
ISSN
  • 1354-6805 (ISSN-L)
  • 1464-0619
DOI
10.1080/13546800903073291
OpenAlex
W2011739018
Cited by
117
References
184
Citations by year
2026: 4 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 7 · 2013: 11 · 2012: 10
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Locations
  • Cognitive Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Keywords
semantic memory, schizophrenia, semantic memory impairment, naming, verbal fluency, picture-word matching, priming, categorization, executive dysfunction, formal thought disorder, cognitive impairment
MeSH terms
Concept Formation, Humans, Memory, Memory Disorders, Schizophrenia, Schizophrenic Psychology, Verbal Behavior, Executive Function

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