CoChat
Sign Up
Cited by 11Suicide and Self-Harm StudiesGenetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

The association between leptin receptor polymorphism and suicidal behaviour in depressed adolescents

Acikel, S. Burak, Eroglu, Canan, Ugras Dikmen, Asiye, Kurar, Ercan·2020·International Journal of Psychiatry in Clinical Practice
DOI 10.1080/13651501.2019.1711422
Open this paper in CoChat — free account

Abstract

Objective: Suicide is the second leading cause of death in adolescence. Genetic studies implicate the genetic component of suicide independent from associated psychiatric disorder. Although genetics is an important factor that might be associated with suicide, limited progress is achieved to identify the candidate genes in adolescents.Methods: The study included 97 patients and 106 controls. Five leptin receptor single nucleotide polymorphism (SNP) region examined. Depressive scores were measured with Children Depression Inventory and suicidal behaviour was measured by Suicide Probability Scale. Logistic and linear regression analysis used for determining to predictors.Results: In linear regression analysis (R2: 0.786) both previous suicide attempt (B:5.553, t:2.613 p: .035) and having a mutant allele in rs1171276 SNP region (B:4.346 t:2.220 p: .048) have been associated with suicidal behaviour. In logistic regression analysis, family history of depression (p < .0001, OR: 4.2 [1.7–9.6]) and number of stressful life events (p: .001, OR: 1.7 [1.3–2.1]) predicted depression significantly.Conclusion: Leptin receptor polymorphism could result in an increase in impulsive behaviour and suicide scores with leptin resistance. Our research is the first study to investigate the relationship between depression, suicidal behaviour and leptin receptor polymorphism in adolescent sample. Similar studies could be carried out on a community basis.KEY POINTSAn association has been found between rs1171276 single nucleotide polymorphism of leptin receptor and the suicide probability scores in depressed adolescents.Family history of depression and number of stressful life events predict depressive scores significantly.Leptin receptor single nucleotide polymorphism may be a risk factor for adolescent suicide by increasing impulsive behaviour.

Integrity signals

Registry

Crossref · 10.1080/13651501.2019.1711422

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A genetic study in adolescents found that carriers of the mutant allele in the rs1171276 region of the leptin gene were more likely to exhibit suicidal behavior.

    “A genetic study in adolescents found that carriers of the mutant allele in the rs1171276 region of the leptin gene were more likely to exhibit suicidal behavior (92).”

    From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [92]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Acikel, S. B., Eroglu, C., Ugras Dikmen, A., & Kurar, E.
Affiliations
  • University of Health Sciences, Dr. Sami Ulus Maternity and Children's Health Hospital, Department of Child and Adolescent Psychiatry Ankara, Turkey;
  • Department of Medical Biology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey;
  • Department of Public Health, Gazi University School of Medicine, Ankara, Turkey
  • Necmettin Erbakan University (TR)
ORCID
Kurar, Ercan
Venue
International Journal of Psychiatry in Clinical Practice
Publisher
Informa UK Limited
Published
2020-01-09
Volume
24
Issue
2
Pages
120-126
ISSN
  • 1365-1501 (ISSN-L)
  • 1471-1788
DOI
10.1080/13651501.2019.1711422
OpenAlex
W3000017164
Cited by
11
References
31
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Psychiatry in Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
leptin receptor, single nucleotide polymorphisms, suicidal behavior, adolescent depression, suicide risk, leptin resistance, family history of depression, life events, candidate genes, impulsivity
MeSH terms
Adolescent, Adolescent Behavior, Depressive Disorder, Female, Humans, Impulsive Behavior, Male, Risk Factors, Stress, Psychological, Suicide, Attempted, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review