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Cited by 99Suicide and Self-Harm StudiesTreatment of Major DepressionStress Responses and Cortisol

Depressed suicide attempters have smaller hippocampus than depressed patients without suicide attempts

Colle, Romain, Chupin, Marie, Cury, Claire, Vandendrie, Christophe, Gressier, Florence, Hardy, Patrick, Falissard, Bruno, Colliot, Olivier +2 more·2015·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2014.12.010
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Abstract

Background Despite known relationship between hippocampal volumes and major depressive episodes (MDE) and the increased suicidality in MDE, the links between hippocampal volumes and suicidality remain unclear in major depressive disorders (MDD). If the hippocampus could be a biomarker of suicide attempts in depression, it could be useful for prevention matters. This study assessed the association between hippocampal volumes and suicide attempts in MDD.Methods Hippocampal volumes assessed with automatic segmentation were compared in 63 patients with MDD, with (n = 24) or without (n = 39) suicide attempts. Acute (<one month) and past (>one month) suicide attempts were studied.Results Although not different in terms of socio-demographic, MDD and MDE clinical features, suicide attempters had lower total hippocampus volumes than non-attempters (4.61 (± 1.15) cm(3) vs 5.22 (± 0.99) cm(3); w = 625.5; p = 0.03), especially for acute suicide attempts (4.19 (± 0.81) cm(3) vs 5.22 (± 0.99) cm(3); w = 334; p = 0.005), even after adjustment on brain volumes, sex, age, Hamilton Depression Rating Scale (HDRS) scores and MDD duration. A ROC analysis showed that a total hippocampal volume threshold of 5.00 cm(3) had a 98.2% negative predictive value for acute suicide attempts.Conclusion Depressed suicide attempters have smaller hippocampus than depressed patients without suicide attempts, independently from socio-demographics and MDD characteristics. This difference is related to acute suicide attempts but neither to past suicide attempts nor to duration since the first suicide attempt, suggesting that hippocampal volume could be a suicidal state marker in MDE. Further studies are required to better understand this association.

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Crossref · 10.1016/j.jpsychires.2014.12.010

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  • Low brain BDNF in the hippocampus of suicide decedents may underlie its smaller size in suicide decedents and attempters and fewer mature granule neurons in its dentate gyrus.

    “Low brain BDNF in the hippocampus of suicide decedents (180) may underlie its smaller size in suicide decedents (69) and attempters (194) and fewer mature granule neurons in its dentate gyrus (70).”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [194]

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Authors
Colle, R., Chupin, M., Cury, C., Vandendrie, C., Gressier, F., Hardy, P., Falissard, B., Colliot, O., Ducreux, D., & Corruble, E.
Affiliations
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Colle, Romain
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2015-02
Volume
61
Pages
13-18
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2014.12.010
OpenAlex
W1981945947
Cited by
99
References
37
Citations by year
2026: 3 · 2025: 12 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 14 · 2020: 8 · 2019: 8 · 2018: 31 · 2017: 4 · 2016: 1 · 2015: 1
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • French Ministry of Health (AOR10071)
  • Assistance Publique – Hôpitaux de Paris (P060219)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
hippocampal volume, suicide attempts, major depressive disorder, hippocampal atrophy, neuroimaging of depression, suicide prevention
MeSH terms
Adolescent, Adult, Aged, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Risk Factors, Suicide, Attempted, Case-Control Studies, Young Adult

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